University of Groningen
Long-term adverse effects of cancer treatment
Westerink, Nico-Derk Lodewijk
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Publication date: 2018
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Westerink, N-D. L. (2018). Long-term adverse effects of cancer treatment: Susceptibility and intervention strategies. Rijksuniversiteit Groningen.
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Long-term adverse effects
of cancer treatment
Susceptibility and intervention strategies
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Westerink, Nico-Derk Lodewijk, 2018
Long-term adverse effects of cancer treatment: susceptibility and intervention strategies Thesis, University of Groningen, The Netherlands
© Copyright 2018, Nico-Derk Lodewijk Westerink, Groningen, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior permission of the author or, when appropriate, of the publisher of the published articles.
Cover design: Gerdia van Staveren
Lay-out: Douwe Oppewal, www.oppewal.nl Printing: Ipskamp Printing B.V.
The research presented in this thesis was conducted at the Department of Medical Oncology, University of Groningen, University Medical Center Groningen. This research project was financially supported by The Dutch Cancer Society, project number 2011-5265.
The printing of this thesis was financially supported by the Stichting Werkgroep Interne Oncologie, Rijksuniversiteit Groningen, Universitair Medisch Centrum Groningen and the Stichting Beroepsopleiding Huisartsen (SBOH), and are gratefully acknowledged.
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Long-term adverse effects
of cancer treatment
Susceptibility and intervention strategies
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 13 juni 2018 om 14.30 uur
door
Nico-Derk Lodewijk Westerink
geboren op 21 juni 1985 te IJsselmuiden
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Promotor
Prof. dr. J.A. Gietema
Copromotores
Dr. A.H. Vrieling Dr. A.M.E. Walenkamp
Beoordelingscommissie
Prof. dr. ir. J.J.M. van der Hoeven Prof. dr. J.G.W. Kosterink Prof. dr. D.J. van Veldhuisen
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Paranimfen
Joël Harms Jacco Westerink
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CONTENTS
Chapter 1 9
General introduction
Chapter 2
17
Cancer treatment induced metabolic syndrome: Improving outcome with lifestyle
Chapter 3
35
Single nucleotide polymorphism in the 5-α-reductase gene (SRD5A2) is
associated with increased prevalence of metabolic syndrome in
chemotherapy-treated testicular cancer survivors
Chapter 4
49
Optimal timing of a tailored physical exercise program during cancer
chemotherapy to reduce long-term cardiovascular morbidity - ACT trial:
design and a preliminary report on cardiorespiratory fitness and vascular markers
Chapter 5
71
Potential genetic predisposition for anthracycline-associated cardiomyopathy
in families with dilated cardiomyopathy
Chapter 6
85
Bleomycin-induced pulmonary changes on restaging computed tomography
scans in two thirds of testicular cancer patients show no correlation with
fibrosis markers
Chapter 7
101
Variation in the HFE gene is associated with the development of
bleomycin-induced pulmonary toxicity in testicular cancer patients
Chapter 8 115
Summary, discussion and future perspectives
Chapter 9 125
Nederlandse samenvatting (Dutch summary)
Supplemental files
131
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