University of Groningen
Porphyromonas gingivalis – an oral keystone pathogen challenging the human immune
system
Stobernack, Tim
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2019
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Stobernack, T. (2019). Porphyromonas gingivalis – an oral keystone pathogen challenging the human
immune system. University of Groningen.
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Porphyromonas gingivalis – An oral keystone
pathogen challenging the human immune system
Tim Stobernack
Porphyromonas gingivalis
An oral keystone pathogen challenging
the human immune system
Porphyromonas gingivalis - An oral keystone pathogen challenging the human immune system
Dissertation of the University of Groningen
ISBN: 978-94-034-1764-6 (printed version) ISBN: 978-94-034-1763-9 (electronic version)
Cover photo: Porphyromonas gingivalis being caught by neutrophil extracellular traps (NETs) Layout by: Bregje Jaspers, ProefschriftOntwerp.nl
Printed by: Ipskamp drukkers Copyright © Tim Stobernack, 2019
The work described in this thesis was performed in the Laboratory of Molecular Bacteriology, Department of Medical Microbiology of the University of Groningen and the University Medical Center Groningen (The Netherlands).
Printing of this thesis was financially supported by the Graduate School of Medical Sciences of the University of Groningen and the Groningen University Library. Their support is highly appreciated.
Porphyromonas gingivalis – An oral keystone
pathogen challenging the human immune system
PhD Thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Monday 1 July 2019 at 12.45 hours by
Tim Stobernack
born on 23 September 1989 in Wesel, Germany
Supervisors
Prof. J. M. van Dijl Prof. A. J. van Winkelhoff Prof. P. Heeringa Co-supervisor Dr. J. Westra Assessment committee Prof. M. Schmidt Prof. Y. Stienstra Prof. U. Völker
Paranymphs
Dr. Corinna Glasner Bimal Prajapati
Table of contents
Chapter 1 General introduction and scope of this thesis 9
Chapter 2 The peptidylarginine deiminase gene is a conserved feature of
Porphyromonas gingivalis
Scientific Reports 2015 Sep 25;5:13936
25
Chapter 3 There’s no place like OM: Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis
Virulence. 2018 Jan 1;9(1):456-464
41
Chapter 4 Extracellular proteome and citrullinome of the oral pathogen
Porphyromonas gingivalis
Journal of Proteome Research 2016 Dec 2;15(12):4532-4543
59
Chapter 5 A secreted bacterial peptidylarginine deiminase can neutralize human innate immune defenses
mBio. 2018 Oct 30;9(5). pii: e01704-18. doi: 10.1128/mBio.01704-18
85
Chapter 6 The peptidylarginine deiminase enzyme of Porphyromonas gingivalis modulates the proteome of human neutrophils and macrophages
Manuscript under revision for publication in Journal of Proteome Research
109
Chapter 7 Summary and future perspectives 139
Chapter 8 Nederlandse samenvatting List of publications Biography
Acknowledgements – Dankwort – Dankwoord
159 164 167 169
