University of Groningen
Porphyromonas gingivalis – an oral keystone pathogen challenging the human immune
system
Stobernack, Tim
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Publication date:
2019
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Stobernack, T. (2019). Porphyromonas gingivalis – an oral keystone pathogen challenging the human
immune system. University of Groningen.
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Propositi ons accompanying the thesis
“Porphyromonas gingivalis
-An oral keystone pathogen challeng ing
the human immune system”
1. Gingiviti s and periodonti ti s probably exist since mammals have evolved teeth (Chapter 1, Gabarrini et al., J. Dent Res., 2018).
2. In the never-ending confl ict between human immune cells and bacterial pathogens, it is crucial for the bacteria to uti lize multi ple smart and eff ecti ve ways of delivering virulence factors to neutralize the host defenses (Chapter 1).
3. The producti on of PPAD by P. gingivalis could be the missing link between periodontal diseases and rheumatoid arthriti s (Chapter 1).
4. Strict conservati on of a gene implies that this gene has been important during the evoluti on of a respecti ve organism up unti l the present day (Chapter 2).
5. The change of a single amino acid in a protein can have a huge impact on a biochemical pathway but does not necessarily aff ect bacterial fi tness (Chapter 3). 6. P. gingivalis has many diff erent faces (Chapter 4).
7. The enzyme PPAD literally neutralizes human innate immune defenses (Chapter 5). 8. One bacterial protein may make all the diff erence to the enti re proteome of human
immune cells (Chapter 6).
9. It should be possible to prevent or treat chronic infl ammatory diseases by therapies as simple as vaccinati on against ‘bad’ bacteria or supplementati on of benefi cial ‘probioti c’ bacteria (Chapter 7).
10. Proteomics is the only omics tool that provides the ‘bigger picture’ of living cells. Genomics and transcriptomics only provide ‘snap shots’ of an organisms potenti als but, in most cases, they do not unveil what is really happening in the ‘movie of life’. 11. The prominent periodontal pathogen P. gingivalis possesses a potent PPAD protein purported to parti cipate in paralysis of parti cular primary immune parameters by powerful permutati ons in the proteome of polymorphonuclear neutrophils. 12. Gingipains are proteases from hell (Jan Maarten van Dijl).
