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Cover Page

The handle http://hdl.handle.net/1887/47855 holds various files of this Leiden University dissertation

Author: Eising, E.

Title: Exploring genes and pathways involved in migraine

Issue Date: 2017-03-15

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EXPLORING GENES AND PATHWAYS

INVOLVED IN MIGRAINE

Else Eising ATHW AYS INV OL VED IN MIGRAINE

Else Eising

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Exploring Genes and Pathways Involved in Migraine

Else Eising

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Copyright of published material in chapters 1-4 and 6-9 lies with the publisher of the journal listed at the beginning of each chapter. No part of this thesis may be reproduced in any form, by print, photocopy, digital file, internet, or any other means without written permission of the copyright holder.

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Exploring Genes and Pathways Involved in Migraine

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op woensdag 15 maart 2017

klokke 15.00 uur

door

Else Eising geboren te Emmen in 1986

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Leden promotiecommissie Prof. dr. S.M. van der Maarel

Prof. dr. D. Posthuma, Vrije Universiteit Amsterdam Prof. dr. E. Slagboom

Dr. A. Maassen van den Brink, Erasmus MC Rotterdam

The work presented in this thesis was supported by grants of the Dutch Organization for Scientific Research (NWO) (Spinoza 2009), the EU-funded FP7 “EUROHEADPAIN” grant (nr. 6026337) and the Center of Medical System Biology established by the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO). Printing of this thesis was supported by the Dutch Headache Society.

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ContEnts

Chapter 1 General introduction

Chapter 2 RNA expression profiling in brains of familial hemiplegic migraine type 1 knock-in mice

Cephalalgia 2014 34: 174-182

Chapter 3 Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine

Molecular Neurobiology 2016 Mar 31 [Epub ahead of print]

Chapter 4 Epigenetic mechanisms in migraine: a promising avenue?

BMC Medicine 2013 11: 26

Chapter 5 Epigenetic signatures of migraine genes in a transgenic mouse model of familial hemiplegic migraine

Chapter 6 Gene-based pleiotropy across migraine with aura and migraine without aura patient groups

Cephalalgia 2016 36: 648-657

Chapter 7 Involvement of astrocyte and oligodendrocyte gene sets in migraine

Cephalalgia 2016 36: 640-647

Chapter 8 Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas

Human Genetics 2016 135: 425-39

Chapter 9 Identifying a gene expression signature of cluster headache in blood

Scientific Reports [in press]

Chapter 10 General discussion Appendix Summary

Nederlandse samenvatting Dankwoord

List of publications Curriculum Vitae

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