Infectious disease studies in zebrafish : the fish pathogen Edwardsiella tarda as a model system
Soest, J.J. van
Citation
Soest, J. J. van. (2011, November 29). Infectious disease studies in zebrafish : the fish pathogen Edwardsiella tarda as a model system. Retrieved from
https://hdl.handle.net/1887/18149
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Infectious disease studies in zebrafish:
the fish pathogen Edwardsiella tarda as a model system
Joost J. van Soest
Cover: Scanning electron microscopy image by Gerda Lamers of Edwardsiella tarda bacteria on the skin of a zebrafish embryo
Printed by: Ridderprint, Ridderkerk, The Netherlands ISBN: 978-90-5335-488-9
Infectious disease studies in zebrafish:
the fish pathogen Edwardsiella tarda as a model system
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 29 november 2011 klokke 13.45 uur
Door
Joost. J van Soest
Geboren te ’s-Gravenhage, Nederland in 1983
Promotiecommissie:
Promotor: Prof. dr. H.P. Spaink
Prof. dr. C.A.M.J.J. van den Hondel Co-Promotor: Dr. A.H. Meijer
Overige leden: Prof. dr. C.J. ten Cate
Dr. G.V. Bloemberg (Universität Zürich, Switzerland) Dr. A.C. Vergunst (INSERM, France)
The printing of this thesis was sponsored by ZF-screens B.V.
“Always look on the bright side of life”
Eric Idle, Monty Python
Voor mijn ouders
Contents
Chapter 1 General introduction 9
Chapter 2 Genome comparisons of Edwardsiella bacteria analysed using deep sequencing technology
37
Chapter 3 Comparison of static immersion and intravenous
injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda
57
Chapter 4 Expression profiling of the response to Edwardsiella tarda infection in a zebrafish myd88 knockout mutant
87
Chapter 5 Summary and discussion 117
Samenvatting 131
Curriculum vitae 147
Publications 149
