Dendritic cells in Melanoma
Polak, M.E.
Citation
Polak, M. E. (2008, September 16). Dendritic cells in Melanoma. Retrieved from https://hdl.handle.net/1887/13100
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13100
Note: To cite this publication please use the final published version (if applicable).
Stellingen
1. Creation of local immunosuppression is an important event in melanoma progression. (This thesis)
2. Dendritic cells pre-condition sentinel lymph nodes for spreading of melanoma cells.
(This thesis)
3. Monocyte-derived dendritic cells do not accurately model the behaviour of tissue dendritic cells. (This thesis)
4. Uveal melanoma shows us that local immunosuppression can be overcome. (This thesis)
5. Melanoma vaccines will not work unless local immunosuppression is overcome.
6. UV radiation not only initiates the creation of cutaneous melanoma but also facilitates its growth by causing immunosuppression in the skin.
7. Maintaining tissue homeostasis, not the initiation of immune reactions, might be the primary role of tissue-residing dendritic cells.
8. Local micro-environment determines molecular pathways of melanoma cancerogenesis.
9. Molecular adaptation of cancer cells to applied therapy may create convenient therapeutical targets in treatment of melanoma.
10. Formation of new blood/lymph vessels is critical for melanoma metastasis.
11. Emigration is the greatest experience for an open mind.
12. Culturing cells is much easier than bringing up kids – they don’t argue with you!
