University of Groningen
Altered lipid and bile acid metabolism in Glycogen Storage Disease type 1a:
pathophysiological mechanisms and therapeutic opportunities
Hoogerland, Joanne
DOI:
10.33612/diss.131695607
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
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Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hoogerland, J. (2020). Altered lipid and bile acid metabolism in Glycogen Storage Disease type 1a: pathophysiological mechanisms and therapeutic opportunities. University of Groningen.
https://doi.org/10.33612/diss.131695607
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Stellingen
behorende bij het proefschrift:
Altered lipid and bile acid metabolism in Glycogen Storage Disease type Ia: pathophysiological consequences and therapeutic opportunities
1. The rare inherited disorder Glycogen Storage Disease Ia can provide novel insights into the pathophysiology of common metabolic diseases characterized by enhanced intrahepatic glucose signaling - This thesis 2. As de novo lipogenesis only minimally contributes to hepatic steatosis
in GSD Ia, pharmacological inhibition of this pathway will have limited therapeutic effectiveness for the treatment of GSD Ia-associated fatty liver disease– This thesis
3. Heterogeneity in hypertriglyceridemia between GSD Ia patients is partially explained by differences in VLDL-triglyceride catabolism – This thesis 4. Preclinical studies using GSD Ia mouse models should be performed in
normo- as well as in hypoglycemic states - This thesis
5. The contribution of hepatic ChREBP activity to fatty liver disease is dependent on the prevailing (patho)physiological condition - This thesis 6. Intrahepatic and extrahepatic (blood) glucose independently regulate
hepatic bile acid synthesis genes – This thesis
7. Intrahepatocytic glucose controls bile acid synthesis and, thereby, modulates intestinal cholesterol handling in mice– This thesis
8. If you can’t explain it simply, you don’t understand it well enough – Albert
Einstein
9. Focus is een kwestie van beslissen welke dingen je niet gaat doen –
Omdenken
10. “Lukt et vandaege nie, dan lukt et merrege wê” – Zeeuws gezegde 11. Lezen is denken met andermans hoofd – Arthur Schopenhauer
Joanne Hoogerland, 14 september 2020
Stellingen Joanne.indd 1
