University of Groningen
Interactions between DNA damage and metabolism Huerta Guevara, Ana
DOI:
10.33612/diss.123699652
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Publication date: 2020
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Citation for published version (APA):
Huerta Guevara, A. (2020). Interactions between DNA damage and metabolism. University of Groningen. https://doi.org/10.33612/diss.123699652
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These propositions belong to the PhD thesis entitled Interactions between DNA damage and metabolism
1. Quitting smoking not only reduces the risk for lung cancer, but also reduces the risk for diabetes. [This thesis]
2. Pancreatic beta-cell dysfunction can trigger systemic responses such as insulin resistance and obesity. [This thesis]
3. Deficient repair of DNA damage in pancreatic beta-cells results in alterations in the structure and functionality of mitochondria and thus, in impaired beta-cell function. [This thesis]
4. Mice with defects in DNA damage repair can be used for the study of pre-diabetic and diabetic conditions as they display progressive impairments in glucose tolerance and only develop diabetic complications after the loss of glucose homeostasis. [This thesis] 5. Although tissue-specific models provide better insight into the specific function of a
gene in a tissue, they usually display more subtle phenotypes as compared to whole body knockout models. [This thesis]
6. The higher prevalence and earlier diagnosis of type 2 diabetes in men can be a consequence of the gender-specific effects in body composition, hyperglycemia and steatosis driven by beta cell dysfunction. [This thesis]
7. Everything starts to make sense when you get older. [Frozen 2]
8. The use of modern technologies will never achieve the emotional deepness attached to receiving a handwritten letter by traditional post. [My mom and me]
9. Half of the unicorns eventually turn out to be just really expensive horses. [The Journal of Financial Economics]
10. If anyone wants to clap, this would be the most suitable time to do it. [Christopher Robin]
Ana Patricia Huerta Guevara 6 May 2020
