University of Groningen
Enterococcus faecium: from evolutionary insights to practical interventions
Zhou, Xue Wei
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2018
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Zhou, X. W. (2018). Enterococcus faecium: from evolutionary insights to practical interventions.
Rijksuniversiteit Groningen.
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Enterococcus faecium:
from evolutionary insights
to practical interventions
The research was partly supported by:
– the INTERREG V A funded project EurHealth-1Health (202085), which is part of a Dutch-German cross-border network supported by the European Union, the Dutch Ministry of Health, Welfare and Sport (VWS), the Ministry of Economy, Innovation, Digitalisation and Energy of the German Federal State of North Rhine-Westphalia and the German Federal State of Lower Saxony – the INTERREG IV A funded project EurSafety Health-net (III-1-02=73) part of a Dutch-German
cross-border network supported by the European Commission, the German Federal States of Nordrhein-Westfalen and Niedersachsen, and the Dutch provinces of Overijssel, Gelderland, and Limburg.
8LITVMRXMRKSJXLMWXLIWMW[EWƼRERGMEPP]WYTTSVXIHF]XLI(MZMWMSRƈ1MGVSFMEP8]TMRKƉSJXLI/2:1 the Graduate School of Medical Sciences and the INTERREG IV/V A projects EurHealth-1Health and EurSafety Health-net. Their support is highly appreciated.
Europäische Union Europese Unie
ISBN: 978-94-034-1130-9 Printed version ISBN: 978-94-034-1129-3 E-book Cover design: Xuewei Zhou
Layout and design: Jules Verkade, persoonlijkproefschrift.nl Printing: Ridderprint BV | www.ridderprint.nl
All rights reserved. No parts of this publication may be reproduced or transmitted in any form or by any means without permission of the author. The copyright of previously published chapters of this thesis also remains with the publisher or journal.
KNVM Divisie Microbiële Typering DMT
Enterococcus faecium:
from evolutionary insights
to practical interventions
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
VIGXSVQEKRMƼGYWTVSJHV)7XIVOIR en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 19 december 2018 om 14.30 uur
door
Xue Wei Zhou
geboren op 6 maart 1987 te Leeuwarden
Promotores Prof. A.W. Friedrich Prof. J.W.A. Rossen
Copromotor Dr. D. Bathoorn
Beoordelingscommissie Prof. J.M. van Dijl 4VSJ.%.;/PY]XQERW Prof. G. Werner
Paranimfen: Esther van Wezel Nicole Dijk
TABLE OF CONTENTS
Chapter 1 Introduction 7
Chapter 2 Enterococcus faecium: from fundamental insights to practical recommendations for infection control and microbiological diagnostics
Submitted
15
Chapter 3 )TMHIQMSPSK]SJ)\XIRHIH7TIGXVYQ¼PEGXEQEWITVSHYGMRKE. coli and vancomycin-resistant enterococci in the Northern Dutch-German cross- border region
Frontiers in Microbiology-Evolutionary and Genomic Microbiology 2017 Oct 5;8:1914
49
Chapter 4 Algorithm for pre-emptive glycopeptide treatment in patients with haematologic malignancies and an Enterococcus faecium bloodstream infection
Antimicrobial Resistance and Infection Control 2013 Sep 11;2(1):24
79
Chapter 5 Evaluation of the Xpert vanA/vanB assay using enriched inoculated broths for the direct detection of vanB VRE
Journal of Clinical Microbiology 2014 Dec;52(12):4293-7
103
Chapter 6 Diagnostic evasion of highly-resistant microorganisms: a critical factor in nosocomial outbreaks Frontiers in Microbiology-Antimicrobials, Resistance and Chemotherapy 2017 Nov 3;8:2128
115
Chapter 7 Elucidating vancomycin-resistant Enterococcus faecium outbreaks: the role of clonal spread and movement of mobile genetic elements.
Accepted for publication in Journal of Antimicrobial Chemotherapy
129
Chapter 8 Summary, conclusion & discussion and future perspectives 151
Chapter 9 Nederlandse samenvatting Dankwoord
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