University of Groningen
Exposure to toxic environments across the life course
Zeng, Zhijun
DOI:
10.33612/diss.126339903
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zeng, Z. (2020). Exposure to toxic environments across the life course: consequences for development, DNA methylation and ageing. https://doi.org/10.33612/diss.126339903
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Propositions related to the thesis Stellingen behorende bij het proefschrift
Exposure to toxic environments across the life course: Consequences for development, DNA methylation and ageing
1. Natural promoter methylation patterns of Igf1 across fetal, neonatal stage and adulthood are organ-specific. (Chapter 2 of this thesis)
2. Prenatal smoke exposure changes Igf1 promoter methylation acrossthree different developmental stages in an organ- and sex-specific way. (Chapter 2 of this thesis) 3. Smoking contributes to features of lung ageing by its effects on the IGF1 pathway.
(Chapter 3 of this thesis)
4. Smoking-induced features of lung ageing are only modestly affected by prenatal smoke exposure. (Chapter 3 of this thesis)
5. Maternal exposure to e-waste-originated heavy metals is associated with epigenome-wide differential methylation in neonates and the risk of adverse health consequence in later life. (Chapter 4 of this thesis)
6. Childhood exposure to atmospheric PM2.5-bound PAHs from e-waste is negatively
associated with growth and linked with reduced plasma IGF1 levels. (Chapter 5 of this thesis)
7. There is no minimum toxicity dose of cigarette smoke at any developmental stage. 8. An effort by both the general public and phone companies to extend the lifespan of smart phones will, even only by 20%, have a significant positive impact on the health of people living in e-waste areas, particularly women and children.
9. If you can't explain it simply, you don't understand it well enough. -Albert Einstein 10. Learning without thinking leads to confusion; thought without learning is perilous
