University of Groningen
Exposure to toxic environments across the life course Zeng, Zhijun
DOI:
10.33612/diss.126339903
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Publication date: 2020
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Citation for published version (APA):
Zeng, Z. (2020). Exposure to toxic environments across the life course: consequences for development, DNA methylation and ageing. https://doi.org/10.33612/diss.126339903
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Exposure to toxic environments across
the life course:
Consequences for development, DNA methylation
and ageing
Exposure to toxic environments across the life course: Consequences for development, DNA methylation
© Zhijun Zeng, 2020
All right reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior written permission from the author.
ISBN (print):978-94-034-2739-3 ISBN (digital):978-94-034-2740-9
Cover design: Qihua Wang Layout: Zhijun Zeng
Printed by: GILDEPRINT, the Netherlands - www.gildeprint.nl
The research in this thesis was financially supported by the Abel Tasman Talent Program (ATTP), University Medical Center Groningen; the Netherlands Lung Foundation (LF 3.2.11.013); the J.K. de Cock foundation; the institute GUIDE; the Natural Science Foundation of China (21577084, 21876065);
Printing of this thesis was financially supported by University of Groningen, GUIDE and Graduate School of Medical Sciences (GSMS)
Exposure to toxic environments
across the life course:
Consequences for development, DNA methylation and ageing
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Wednesday 27 May at 11.00 hours by
Zhijun Zeng Born on 02 June 1988
Supervisors Dr. M.N. Hylkema Prof. dr. X. Xu Co-supervisor Dr. C.A. Brandsma Assessment Committee Prof. dr. S. Krauss-Etschmann Prof. dr. A.F. Bos
Paranimfen
Khosbayar Lkhagvadorj Yu Zhang
CONTENT
Chapter 1 General introduction
Scope of the thesis
11 19
Chapter 2 Prenatal smoke effect on mouse offspring Igf1
promoter methylation from fetal stage to adulthood is organ- and sex-specific
31
Chapter 3 Effects of pre- and/or postnatal smoke exposure on
the hallmarks of the ageing phenotype and the role for the IGF1 pathway
65
Chapter 4 Differential DNA methylation in newborns with
maternal exposure to heavy metals from an e-waste recycling area
97
Chapter 5 PM2.5-bound PAHs exposure is linked with low
plasma insulin-like growth factor 1 levels and reduced child height
133
Chapter 6 Summary, general discussion and future perspective 165
Chapter 7 Nederlandse samenvatting
Acknowledgements Curriculum Vitae
