Endocrine and metabolic features of familial longevity : the Leiden Longevity Study

In this study we related serum IGF-1 levels in nonagenarian siblings from the Leiden Longevity Study to the family mortality history score of their parents.. We

We have compared serum thyroid hormone function parameters in a group of middle-aged offspring of long-living nonagenarian siblings and a control group of their partners, all

The relation between lower family history score of the parents of the nonagenarian siblings and higher thyrotropin along with lower serum thyroxine levels in the

The purpose of this study was to investigate a mutual association between triiodothyronine and pro-inflammatory cytokines. Here, we show that higher circulating

When mortality rates are expressed on an absolute scale (figure 1b) the slope of the tangent line at the age 60 years is much steeper among the prisoners of war

All estimates of the parameters were significantly different between the three groups and from zero (p<0.001). Age-specific senescence rates of patients on dialysis,

This study showed that using the derivative function of the Gompertz curve identifies different rates of senenscence under various conditions. In contrast to the parameter G

Invaluable was the assistance of the secretary and nursing staff of the Department of Gerontology and Geriatrics at Leiden University Medical Centre, as well as