Endocrine and metabolic features of familial longevity : the Leiden Longevity Study
Rozing, M.P.
Citation
Rozing, M. P. (2011, September 21). Endocrine and metabolic features of familial longevity : the Leiden Longevity Study. Retrieved from https://hdl.handle.net/1887/17849
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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ENDOCRINE AND METABOLIC FEATURES OF FAMILIAL LONGEVITY:
THE LEIDEN LONGEVITY STUDY
MAARTEN P. ROZING
ISBN 978-94-6108-211-4
© 2011 M.P. Rozing
Copyright of each chapter is with the publisher of the journal in which the work has appeared.
No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without permission of the author or, when appropriate, of the publisher of publications.
Design & Layout A.M. Christiaanse and M.P. Rozing Cover illustration Jan Lievens, Vanitas stilleven ca. 1627 Printed by GildePrint, Enschede
This research was performed within the framework of the Netherlands Consortium for Healthy Ageing, which is financially supported by the Netherlands Genomics Initiative (project number 050-060-810).
Financial support by the Netherlands Consortium for Healthy Ageing for the publication of this thesis is gratefully acknowledged.
THE LEIDEN LONGEVITY STUDY
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van de Rector Magnificus prof. Mr. P.F. van der Heijden volgens het besluit van het College der Promoties
te verdedigen op woensdag 21 september 2011 klokke 16:15
door
Maarten Pieter Rozing geboren te Leiderdorp
in 1979
Promotiecommissie
Promotores:
Prof. dr. R.G.J. Westendorp Prof. dr. P.E. Slagboom
Co-promotor:
Dr. ir. D. van Heemst
Overige leden:
Prof. dr. B. Demeneix (Centre National de la Recherche Scientifique, Museum National d'Histoire Naturelle, Parijs, Frankrijk)
Prof. dr. J.H.J. Hoeijmakers (Erasmus Universiteit Rotterdam) Prof. dr. H. Pijl
Contents
Chapter 1: General introduction ... 7
PART A: ON THE ENDOCRINE AND METABOLIC FEATURES OF FAMILIAL LONGEVITY: THE LEIDEN LONGEVITY STUDY ... 13
Chapter 2: Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study ... 15
Chapter 3: Favorable glucose tolerance and lower prevalence of metabolic syndrome in non- diabetic offspring of nonagenarian siblings: the Leiden Longevity Study. ... 27
Chapter 4: Familial longevity is marked by enhanced insulin sensitivity ... 43
Chapter 5: C-reactive protein and glucose regulation in familial longevity ... 63
Chapter 6: Human insulin/IGF-1 and familial longevity at middle age ... 79
Chapter 7: Reduced serum IGF-1 and familial longevity ... 95
Chapter 8: Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study ... 105
Chapter 9: Familial longevity is associated with decreased thyroid function ... 115
Chapter 10: Serum triiodothyronine levels and inflammatory cytokine production capacity ... 127
Chapter 11: General discussion and synopsis of part A ... 141
PART B: ON DETERMINING THE RATE OF SENESCENCE ... 153
Introduction to part B ... 155
Chapter 12: Parallel lines: nothing has changed? ... 157
Chapter 13: Senescence rates in patients with end-stage renal disease: a critical appraisal of the Gompertz model ... 169
General discussion and synopsis part B ... 183
PART C: APPENDICES ... 185
Appendix A: General discussion and synopsis in Dutch Part A. ... 187
Appendix B: General discussion and synopsis in Dutch Part B. ... 199
Appendix C: Acknowledgements……….201
Appendix D: Curriculum vitae ... 203
Appendix E: List of publications ... 205
