Genetic determinants of eating disorders
Slof-Op 't Landt, M.C.T.
Citation
Slof-Op 't Landt, M. C. T. (2011, June 28). Genetic determinants of eating disorders.
Retrieved from https://hdl.handle.net/1887/17737
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Genetic Determinants of Eating Disorders
Rita Slof-Op ‘t Landt
Genetic determinants of Eating Disorders Rita Slof-Op ‘t Landt
PhD thesis with summary in Dutch ISBN 978-94-91211-49-2
© 2011 M.C.T. Slof-Op ‘ t Landt
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form by any means, without permission of the author or, when
appropriate, of the publisher of publications.
Cover by Else Marie Bos Design (elsemariebos.nl) Printed by Ipskamp drukkers
Genetic Determinants of Eating Disorders
Proefschrift
ter verkrijging van de graad Doctor aan de Universiteit van Leiden, op gezag van Rector Magnificus prof. Mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 28 juni 2011
klokke 15.00 uur
door
Margarita Cornelia Theodora Slof-Op ’t Landt
geboren te Ter Aar in 1980
Promotiecommissie
Promotores Prof. Dr. P.E. Slagboom
Prof. Dr. D.I. Boomsma (Vrije Universiteit Amsterdam)
Co-promoter Dr. E.F. van Furth (Centrum Eetstoornissen Ursula)
Overige leden Prof. Dr. R.A.H. Adan (Universiteit Utrecht)
Prof. Dr. C.M. Bulik (University of North Carolina, USA) Prof. Dr. F.G. Zitman
Contents
Chapter 1 Introduction 7
Chapter 2 Eating disorders: from twin studies to candidate genes and beyond 23
Chapter 3 Sex differences in sum score may be hard to interpret: the
importance of measurement invariance 43
Chapter 4 Genetic influences on disordered eating behavior are largely
independent of BMI 57
Chapter 5 Association study in eating disorders: TPH2 associates with
anorexia nervosa and self-induced vomiting 73
Chapter 6 Genetic variation at the TPH2 gene influences impulsivity in
addition to eating disorders 91
Chapter 7 General discussion 107
Chapter 8 Summary 123
Chapter 9 Nederlandse samenvatting 129
References 139
Appendix A – DSM-IV criteria for eating disorders 161
Appendix B – Large association studies in eating disorders from
2005 to present 163
Appendix C – References of small genetic association studies in
eating disorders from 2005 to present 175
Appendix D – References of small genetic association studies in
eating disorders until 2005 177
Publications 185
Curriculum vitae 189
