A Drosophila model for Duchenne muscular dystrophy
Plas, M.C. van der
Citation
Plas, M. C. van der. (2008, January 24). A Drosophila model for Duchenne muscular dystrophy. Retrieved from https://hdl.handle.net/1887/12577
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A Drosophila Model for Duchenne Muscular Dystrophy
The Role of Dystrophin in Muscle and Nervous System
Mariska C. van der Plas
A Drosophila Model for Duchenne Muscular Dystrophy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. mr. P. F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 24 januari 2008 klokke 16:15 uur
door
Mariska C. van der Plas geboren te Gouda
in 1980
Promotiecommissie
Promotor: Prof. Dr. J.N. Noordermeer Co-promotor: Dr. L.G. Fradkin
Referent: Dr. R.A. Baines, University of Manchester, UK
Overige leden: Prof. Dr. H.J. Tanke
Prof. Dr. G.J.B. van Ommen Prof. Dr. E.R. de Kloet Dr. J.J. Plomp
The studies described in this thesis were performed at the department of Molecular Cell Biology, Leiden University Medical Center.
This research has been made possible by a pionier grant of the Netherlands Organisation for Scientific Research (NWO) grant number 900-02-003. The financial support of Leica Microsystems B.V. in printing this thesis is gratefully acknowledged.
Cover: ‘Degenerating leaves’. Photographer: Walmink.
“It was the best of times, it was the worst of times, it was the age of wisdom, it was the age of foolishness, it was the epoch of belief, it was the epoch of incredulity, it was the season of Light, it was the season of Darkness, it was the spring of hope, it was the winter of despair, we had everything before us, we had nothing before us, we were all going direct to heaven, we were all going direct the other way - in short, the period was so far like the present period, that some of its noisiest authorities insisted on its being received, for good or for evil, in the superlative degree of comparison only.”
Charles Dickens (1812-1870), A Tale of Two Cities.
“Where so many hours have been spent in convincing myself that I am right, is there not some reason to fear I may be wrong?”
Jane Austen (1775 - 1817), Sense and Sensibility.
“W..e a..p..o..l..o..g..i..z..e for the i..n..c..o..n..v..e..n..i..e..n..c..e”
(God’s Final Message to His Creation) Douglas Adams (1952-2001), So long, and thanks for all the fish.
Contents of this thesis
Chapter 1 Introduction
9
Chapter 2 Embryonic expression patterns of the Drosophila
dystrophin-associated glycoprotein complex orthologs. 45 Dekkers LC, van der Plas MC, van Loenen PB, den Dunnen JT, van
Ommen GJ, Fradkin LG, Noordermeer JN.
Gene Expression Patterns 4(2) (2004) 153-159.
Chapter 3 Dystrophin Is Required for Appropriate Retrograde Control of Neurotransmitter Release at the Drosophila Neuromuscular Junction.
55
van der Plas MC, Pilgram GSK, Plomp JJ, de Jong A, Fradkin LG, Noordermeer JN.
The Journal of Neuroscience 26(1) (2006) 333–344.
Chapter 4 The Dp186 Dystrophin Isoform Mediates Regulation of Neurotransmitter Release at Central Synapses in Drosophila.
83
Fradkin LG, Baines RA, van der Plas MC, Noordermeer JN.
The Journal of Neuroscience, in revision.
Chapter 5 The Drosophila Dystrophin Dp117 Isoform Is Required For
Muscle Integrity. 101
van der Plas MC, Pilgram GSK, de Jong A, Bansraj MRKS, Fradkin LG, Noordermeer JN.
Mechanisms of Development 124 (2007) 617-630.
Chapter 6 The role of Drosophila Dystrobrevin in survival, muscle
integrity, and wing formation. 125
Van der Plas MC, Kremer A, de Jong AWM, Fradkin LG, Noordermeer JN.
Chapter 7 General Discussion 145
Chapter 8 Summary 159
Nederlandse samenvatting 163
List of publications 165
Curriculum vitae 167
Appendix Color figures 169
