Diacylglycerol kinase theta and zeta isoforms: regulation of activity,
protein binding partners and physiological functions
Los, Alrik Pieter
Citation
Los, A. P. (2007, January 25). Diacylglycerol kinase theta and zeta isoforms: regulation of
activity, protein binding partners and physiological functions. Retrieved from
https://hdl.handle.net/1887/9451
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/9451
Note: To cite this publication please use the final published version (if applicable).
D i a c y l g l y c e r o l k i n a s e t h e t a a n d z e t a i s o f o r m s : R e g u l a t i o n o f a c t i v i t y, p r o t e i n b i n d i n g p a r t n e r s a n d p h y s i o l o g i c a l f u n c t i o n s
Design
Crispijn Los J oris S m id t P r int ed b y
P rint P a rt ne rs I psk a m p B .V ., A m st e rd a m
Diacylglycerol
kinase theta and
zeta isoforms:
Regulation of activity,
protein binding
partners and physio-
logical functions
P roefschrift
ter verkrijging van
de graad van D oc tor aan de U niversiteit Leiden, op gez ag van de R ec tor M agnif ic u s D r. D .D . Breimer,
h oogleraar in de f ac u lteit der W isku nde en N atu u rw etensc h appen en die der G eneesku nde,
volgens b eslu it van h et College voor Promoties te verdedigen op donderdag 2 5 janu ari 2 0 0 7
klokke 1 5 :0 0 u u r
door
A lrik P ieter L os
G eboren te ’s- H ertogenbosch in 1 9 7 5
P romotiecommissie
Promotor
Prof. Dr. W. H. Moolenaar C o- p romotores
Dr. N. Divecha
Nederlands Kanker Instituut, Amsterdam Dr. W. J. van Blitterswijk
Nederlands Kanker Instituut, Amsterdam R ef erent
Prof. Dr. J. J. Neefjes O v erige l eden
Prof. Dr. P. ten Dijke
T he research described in this thesis was performed at the
Division of Cellular Biochemistry of the Netherlands Cancer Institute, Amsterdam. T his work was supported by the Dutch Cancer Society , grant NK I 2000- 2209 .
Publication of this thesis was financially supported by the Netherlands Cancer Institute and the Dutch Cancer Society .
7
Contents
Chapter 1
I ntroduction to the signalling functions
of diacylglycerol kinase-c and -e isoforms...9
Chapter 2
S tructure– activity relationship of diacylglycerol
kinase e.
(BBA. 2004 Mar 22;1636(2-3):169-174)...4 5
Chapter 3
I ntroduction to the family of retinoblastoma
gene products...5 9
Chapter 4
T he retinoblastoma family proteins bind to
and activate diacylglycerol kinase-c
(J BC . 2006 J an 13;28 1(2):8 5 8 -8 66)
...7 5
Chapter 5
Protein kinase
Cinhibits binding of diacylglycerol
kinase-c to the retino blastoma protein
(BBA Mo l e c u l ar C e l l re s e arc h , i n p re s s )
...99
Chapter 6
I s there a role for diacylglycerol kinase-c in cell
cycle regulation? ...1 1 5
Chapter 7
