University of Groningen
Exploring novel personalized treatment options focusing on cancer stem cells Liang, Du
DOI:
10.33612/diss.233699712
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2022
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Liang, D. (2022). Exploring novel personalized treatment options focusing on cancer stem cells. University of Groningen. https://doi.org/10.33612/diss.233699712
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Exploring novel personalized treatment options focusing on cancer stem cells
Liang Du
杜亮
Du, L.
Exploring novel personalized treatment options focusing on cancer stem cells
PhD dissertation, University of Groningen, Groningen, The Netherlands
Printing of this thesis was financially supported by the Graduate School of Medical Sciences, University of Groningen.
Cover: Qianchi design, Liang Du Layout: Liang Du
Printed by: Gildeprint ISBN: 978-94-6419-541-5
Copyright © 2022 All rights reserved.
Exploring novel personalized treatment options focusing on
cancer stem cells
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with the decision by the College of Deans.
This thesis will be defended in public on Monday 19 September 2022 at 16.15 hours
by
Liang Du born on 30 July 1991 in Chongqing, China
Supervisors
Prof. R.P. Coppes Prof. Z. Hao
Assessment Committee
Prof. F.A.E. Kruyt Prof. J. Bussink Prof. A. Dubrovska
Dedicated to My family
谨以此书献给我亲爱的家人
Paranymphs
Yuting Jiang Yan Li
TABLE OF CONTENTS
Chapter 1 General introduction and outline of the thesis. 9 Chapter 2 MTA3-SOX2 Module Regulates Cancer Stemness and
Contributes to Clinical Outcomes of Tongue Carcinoma.
Front Oncol. 2019 Aug 27; 9: 816
19
Chapter 3 MTA3 Represses Cancer Stemness by Targeting the SOX2OT/SOX2 Axis.
iScience. 2019 Dec 20; 22: 353-368
41
Chapter 4 Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling.
Oncogene. 2021 Mar; 40 (11): 1974-1987
85
Chapter 5 Generation and Application of Inducible Chimeric RNA ASTN2-PAPPAas Knockin Mouse Model.
Cells. 2022 Jan 14; 11 (2): 277
119
Chapter 6 Role of mTOR through autophagy in esophageal cancer stemness.
Cancers. 2022 Apr 1; 14 (7): 1806
143
Chapter 7 Esophageal cancer-derived organoids to predict patients' treatment response
Manuscript in preparation
171
Chapter 8 Summary and future perspectives. 191
Chapter 9 Nederlandse samenvatting (Dutch summary) 201
Appendices 207
Acknowledgements 209
Curriculum vitae 213
List of publications 215
