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Cover Page The handle http://hdl.handle.net/1887/66887 holds various files of this Leiden University dissertation. Author: Haane, D.Y.P. Title: Cluster headache and oxygen Issue Date: 2018-11-14

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Cover Page

The handle

http://hdl.handle.net/1887/66887

holds various files of this Leiden University

dissertation.

Author: Haane, D.Y.P.

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Printed by: Drukkerij Pietermans, Lanaken (België)

ISBN: 978-90-9031243-9

© 2018 D.Y.P. Haane

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Cluster headache and oxygen

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus Prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties

te verdedigen op woensdag 14 november 2018

klokke 16.15 uur

door

Danielle Yvonne Peter Haane

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Promotor: Prof. dr. M.D. Ferrari

Copromotoren: Dr. P.J. Koehler (Zuyderland Medisch Centrum, Heerlen) Dr. J. Haan

Promotiecommissie: Prof. dr. A.M.J.M. van den Maagdenberg Mw. dr. G.M. Terwindt

Dr. R. Fronczek

Dr. W.M. Mulleners (Canisius Wilhelmina Ziekenhuis, Nijmegen) Prof. dr. K. Paemeleire (Universitair Ziekenhuis Gent, Gent (België))

The research presented in this thesis was performed at the Department of Neurology and Clinical Neurophysiology of the Atrium Medical Centre (current Zuyderland Medical Centre), Heerlen, The Netherlands.

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Content

Introduction

Chapter 1. Introduction & Scope of this thesis 7

Part I. History of oxygen therapy in cluster headache

Chapter 2. The history of oxygen inhalation as a treatment for cluster headache 19

Part II. Factors predicting response to oxygen therapy in cluster headache

Chapter 3. Cluster headache and oxygen: is it possible to predict which patients

will be relieved? A retrospective cross-sectional correlation study 31

Chapter 4. Cluster headache and oxygen: is it possible to predict which patients

will be relieved? A prospective cross-sectional correlation study 49

Part III. Encountered other effects of oxygen therapy in cluster headache

Chapter 5. Rebound following oxygen therapy in cluster headache 65

Part IV. Blink reflex studies in cluster headache

Chapter 6. Nociception specific supraorbital nerve stimulation may prevent

cluster headache attacks: serendipity in a blink reflex study 75

Chapter 7. High-flow oxygen therapy in cluster headache patients has no

significant effect on nociception specific blink reflex parameters: a pilot study 86

Summary & Future perspectives

Chapter 8. Summary & Future perspectives 94

Chapter 9. Samenvatting & Toekomstperspectieven 102

Dankwoord

111

Curriculum vitae

113

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Appendices

117

Appendix A 118

Appendix B 131

Referenties

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