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Cover Page The handle http://hdl.handle.net/1887/55262 holds various files of this Leiden University dissertation. Author: Pawlak, J.B. Title: Bioorthogonal Antigens Issue Date: 2017-11-14

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Cover Page

The handle http://hdl.handle.net/1887/55262 holds various files of this Leiden University dissertation.

Author: Pawlak, J.B.

Title: Bioorthogonal Antigens Issue Date: 2017-11-14

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Bioorthogonal Antigens

PROEFSCHRIFT

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C. J. J. M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op dinsdag 14 november 2017

klokke 15:00 uur

door

Joanna Barbara Pawlak

Geboren te Olsztyn, Polen in 1983

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Promotiecommissie

Promotor: Prof. dr. H. S. Overkleeft

Co-promotor: Dr. S.I. van Kasteren

Overige leden: Prof. dr. M.H.M. Noteborn (LU) Prof. dr. J. Brouwer (LU) Prof. dr. J.J. Neefjes (LUMC)

Prof. dr. H. L. Ploegh (Children's Hospital Boston and Harvard Medical School)

Dr. I. Berlin (LUMC)

Dr. M. van der Stelt (LU)

Printed by Ridderprint B.V.

All rights reserved. No part of this book may be reproduced in any manner or by any means without permission.

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Dla Taty

"It always seems impossible until it's done."

- Nelson Mandela

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Table of Contents

Chapter 1 5

General introduction

Chapter 2 15

Tools for studying antigen processing and cross-presentation

Chapter 3 31

The optimization of bioorthogonal epitope ligation within MHC-I complexes

Chapter 4 59

Towards imaging of bioorthogonal antigens throughout antigen cross-presentation

Chapter 5 77

Bioorthogonal deprotection on the dendritic cell surface allows chemical control of antigen cross-presentation

Chapter 6 93

Summary and future prospects

Streszczenie 101

List of Publications 104

Curriculum Vitae 105

Referenties

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