Citation
Habets, K. L. L. (2009, December 8). The potential use of dendritic cells in mouse models of atherosclerosis. Retrieved from
https://hdl.handle.net/1887/14484
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Therapeutic potential of dendritic cells in mouse models of atherosclerosis
Kim L.L. Habets
Therapeutic potential of dendritic cells in mouse models of atherosclerosis
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 8 december 2009 klokke 11.15 uur
door
Kim Linda Liesje Habets geboren te Maaseik
in 1979
Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was financially supported by:
LACDR
Leiden University Genzyme Beckman Coulter
Special Diet Services (representend by Tecnilab-BMI)
“I have a dad who is watching over me”
K’s Choice
Aan mijn ouders Voor Pieter
Proefschrift Leiden
Met literatuur opgave - Met samenvatting in het Nederlands
© 2009 KLL Habets
No parts of this thesis may be reproduced or transmitted in any form or by any means, without permission of the author.
Table of contents
Page
9 Chapter 1:
General Introduction 33 Chapter 2:
Vaccination using oxLDL-pulsed DCs reduces atherosclerosis in LDLr-/- mice
57 Chapter 3:
Immunomodulation with OCH-pulsed dendritic cells attenuates atherosclerosis
79 Chapter 4:
Adoptive transfer of immature dendritic cells prevents progression of established atherosclerosis in LDLr-/- mice 99 Chapter 5:
Deficiency of TGF-β signaling in CD11c+ cells accelerates atherosclerosis by disrupting T-cell homeostasis
119 Chapter 6:
Foam cell formation affects MHC class I processing and presentation in vitro while hypercholesteremia induces a DC- like phenotype in macrophages in vivo
137 Chapter 7:
Potential role of regulatory T cells in aortic aneurysm formation
153 Chapter 8:
General discussion and Perspectives 163 Nederlandse samenvatting
169 Curriculum Vitae 170 List of publications 174 List of abbreviations
