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The handle http://hdl.handle.net/1887/21936 holds various files of this Leiden University dissertation.
Author: Berg, Yascha Wilfred van den Title: Tissue factor isoforms and cancer Issue Date: 2013-10-08
Tissue Factor Isoforms and Cancer
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Tissue Factor Isoforms and Cancer
Proefschrift
ter verkrijging van
de graad van Doctor aan de Univeristeit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 8 oktober 2013
klokke 15:00 uur
door
Yascha Wilfred van den Berg
geboren te Leidschendam in 1982
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Promotiecommissie
Promotores: Prof. dr. P.H. Reitsma Prof. dr. S. Osanto Copromotor: Dr. H.H. Versteeg
Overige leden:` Prof. dr. H.R. Büller (Universiteit van Amsterdam) Prof. dr. C.J.H. van de Velde
Prof. dr. M.J. Goumans Prof. dr. A.J. van Zonneveld
The research described in this thesis was financially supported a Sanofi-Aventis/ISTH fellowship. The research was performed at the Einthoven Laboratory for Experimental Vascular Medicine, Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Financial support by the Dutch Hearth Foundation for publication of this thesis is gratefully acknowledged.
Additional support was kindly provided by Roche Nederland B.V., Novo Nordisk B.V., ChipSoft B.V., GlaxoSmithKline B.V. and Greiner Bio-One B.V..
Cover: Bureau Canard
©2013 by Y.W. van den Berg ISBN: 978-90-8891-694-6 Printed by Boxpress
5 Aan mijn ouders en zus, voor Sarah en Hugo
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Contents
Chapter 1 - General introduction and outline of the thesis 9 Chapter 2 - Alternatively spliced tissue factor induces angiogenesis through integrin
ligation 15
Chapter 3 - Alternatively spliced tissue factor: a crippled protein in coagulation or a key
player in non-hemostatic processes? 41
Chapter 4 - Splice variants of Tissue Factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin ligation 55 Chapter 5 - Non-Proteolytic Properties of Murine Alternatively Spliced Tissue Factor:
Implications for Integrin-Mediated Signaling in Murine Models 81 Chapter 6 - Alternatively spliced and full-length tissue factor have dissimilar properties in
breast cancer 101
Chapter 7 - Ectopic factor VII expression is an indicator of poor survival in young women
with breast cancer 119
Chapter 8 - Disulfide switching: a conserved mechanism in Tissue Factor decryption? 135 Chapter 9 - The relationship between tissue factor and cancer progression: insights from
bench and bedside 141
Chapter 10 - General Discussion and Summary 163
Nederlandse discussie en samenvatting 177
Publications 189
Dankwoord 191
Curriculum Vitae 193
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