The role of abca1 in atherosclerosis: lessons from in vitro and in vivo models
Singaraja, R.R.
Publication date
2003
Link to publication
Citation for published version (APA):
Singaraja, R. R. (2003). The role of abca1 in atherosclerosis: lessons from in vitro and in vivo
models.
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Curriculumm vitae
Curriculumm vitae
Roshnii Stngaraja was born in Sri-Lanka and moved to Canada in 1986. She received her Honours B.Sc. fromm the University of Waterloo in 1990 in Biochemistry. She was then at the University of Guelph, Ontarioo and the University of Toronto, Ontario, working on noninvasive scxing technique; of bovine embryoss in Guelph, and on a maker gene therapy trial in multiple myeloma patients in Toronto. Roshni thenn moved to the University of British Columbia where she worked on Huntington disease in the laboratoryy of Dr. Michael Hayden. In May of 2000, she began studies towards her PhD in the field of lipidd metabolism with Dr. Michael Hayden. While a graduate student, she won an excellence award fromm the Canadian Lipoprotein Organization, and an outstanding achievement by a doctoral student awardd from the University of British Columbia and the Children and Women's Hospital.
Publications s
Zhang,, Y., Leavitt, B.R., Li, M., Drozda, M., Chen, M., Sanchez, R.O., VanRaamsdonk, J., Wellington, C.L.,, Singaraja, R.R., Ren, S., Hersh, S.M., Cattaneo, E., Ona, V.O., Ferrante, R.J., Hayden, M.R., and Friedlander,, R.M. Proteolytic cleavage and dysfunction of wild-type huntingtin in neurologic disease. NatNat Cell Biol. Submitted
Singaraja,, R.R., Brunham, L.R., Visscher, H., Kastelein, 1.1., and Hayden, M.R. 2003. Efflux and
Atherosclerosis.. Arteriosder Thromb Vase Biol. May 22 [Epub ahead of print]
Wellington,, C.L., Brunham, L.R., Zhou, S., Singaraja, R.R., Visscher, H., Gelfer, A., Ross, C, James, E., Liu,, G., Huber, M.T., Yang, Y.Z., Parks, R.J., Groen, A., Fruchart-Najib, J., and Hayden, M.R. 2003. Alterationss of plasma lipids in mice via adenovirual mediated hepatic overexpression of human ABCA1.. J Lipid Res. May 1 [Epub ahead of print]
Singaraja,, R.R., Hadano, S., Metzler, M., Wellington, C, Leavitt, B., Fichter, K., Gan, L., McCutcheon,
K.,, Chopra, V., Ikeda, J.E., and Hayden, M.R. 2002. HIP14, a novel ankyrin domain-containing protein, linkss huntingtin to intracellular trafficking and endocytosis. Hum Mol Gen. 11(23):2815-2828.
Wellington,, C, Yang, Y-Z., Kwok, A., Clee, S.M., Zwartz, K., Marcil, M., Newman, S., Roomp, K.,
Singaraja,, R.R., Zhang, L-H., Kasteiein, J.J.P., Genest, J.Jr., anu I layuen, M.R. 2002. Truncation mutations
inn human ABCA1 suppress normal upregulation of wild-type ABCA1 by 9(cis)retinoic acid and 22(R)-hydroxyy cholesterol. J Lipid Res. 43(11): 1939-1949.
See,, R.H., Caday-Malcolrm, R.A., Singaraja, R.R., Zhou, S., Silverstone, A., Huber, M.T., Moran, J., James,, E., Yang, Y-z., Janoo, R., Wang, M., Wellington, C.L., Tafuri.S.R., and Hayden, M.R. 2002. PKAA site-specific phosphorylation regulates ABCA1-mediated phospholipid efflux. J Biol Chem. 277(44):41835-42. .
Zhang,, L.H., Mulligan, J.D., Singaraja, R.R., Bitgood, J.J., Cook, M.E., Kastelein, J.J., Chimini, G., and Hayden,, M.R. 2002. Identification and functional characterization of a naturally occurring E89K mutationn in the ABCA1 gene of the WHAM chicken. J Lipid Res. 43(10): 1610-1617.
Robitaille,, J., MacDonald, M.L.E., Sheldahl, L.C., Kaykas, A., Zeisler, J., Dube, M-P., Zhang, L-H.,
Singaraja,, R.R., Pimstone, S.N., Shastry, B.S., Hayden, MR., Moon, R.T., Goldberg, Y.P., and
Samuels,, M.E. 2002. M u t a n t frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy.. Nat Genet. 32(2):326-30.
Singaraja,, R.R., Fievet, C, Castro, G., James, E.R., Clee, S.M., Bissada, N., Choy, J., Frutchart, J-C,
McManus,, B., Staels, B., and Hayden, M.R. 2002. Increased ABCA1 activity protects against atherosclerosis.. J Clin Invest. 110(1)35-42.
Wellington,, C.L., Gutekunst, C-A., Leavitt, B.R., Rogers, D., Warby, S., Graham, R.K., VanRaamsdonk, J.,, Loubser, O., Singaraja, R., Yang, Y-Z., Gafni, J., Bredesen, D., Roy, S., Nicholson, D.W., and Hayden,, M.R. 2002. Caspase cieaveage of mutant huntmgtin precedes neurodegeneration in Huntingtonn Disease. J Neurose. 22(18):7862-72.
Zwarts,, K.Y., Clee, S.M., Zwinderman, A.H., Engert, J.C., Singaraja, R., Loubser, O., James, E., Roomp,, K., Hudson, T.J., Jukema, J.W., Kastelein, J.J., and Hayden, M.R. 2002. ABCA1 regulatory variantss influence coronary artery disease independent of effects on plasma lipid levels. Clin Genet.Genet. 61 (2): 11 5-25.
Wellington,, CL., Walker, E.K., Suarez, A., Kwok, A., Bissada, N., Singaraja, R., Yang, Y-Z, Zhang, L.H.,, James, E., Wiison, J.E., Francone, O., McManus, B.M., and Hayden, M.R. 2002. ABCA1 mRNA andd protein distribution patterns predict multiple different roles and levels of regulation. Lab Invest.Invest. 82(3):273-83.
Gervais,, F.G., Singaraja, R., Xanthoudakis, S., Gutekunst,C-A., Leavitt, B.R., Metzier, M., Hackam, A.S.,, Tarn, J., Vaillancourt, J.P., Houtzager, V., Rasper, D.M., Roy, S., Hayden, M.R., and Nicholson, D.W.. 2002. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 andd a novel partner Hippi. Nat Cell Biol. 4{2):95-105.
Hadano,, S., Hand, C.K., Osuga, H., Yanagisawa, Y., Otomo, A., Devon, R.S., Miyamoto, N., Showguchi-Miyata,, J., Okada, Y., Singaraja, R., Figlewicz, D.A., Kwiatkowski, T., Hosier, B.A., Sagie, T.J., Nasir, J.,, Brown, R.H.Jr, Scherer, S.W., Rouleau, G.A., Hayden, M.R., and Ikeda, J.E. 2001. A gene encoding aa putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet. 29(2):166-73. .
Curriculumm vitae
Singaraja,, R.R., Bocher, V., James, E.R., Clee, S.M., Zhang, L.H., Leavitt, B.R., Tan, B.,
Brooks-Wilson,, A., Kwok, A., Bissada, N., Yang, Y-Z., Liu, G., Tafuri, S.R., Fievet, C , Wellington, C.L., Staels, B.,, and Hayden, M.R. 2 0 0 1 . Human ABCA1 BAC transgenic mice show increased HDL-C and ApoA-ll dependant efflux stimulated by an interna! promoter containing LXREs in intron 1. J Biol Chem.Chem. 276(36):33969-79.
Leavitt,, B.R., Guttman, J.A., Hodgson, J.G., Kimel, G.H., Singaraja, R., Vogl, A.W., and Hayden, M.R.. 2001. Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo. Am J HumHum Genet. 68(2):313-24.
Chopra,, V.S., Metzler, M., Rasper, D.M., Engqvist-Goldstem, A.E., Singaraja, R., Gan, L, Fichter, K.M.,, McCutcheon, K., Drubin, D., Nicholson, D.W., and Haydent, M.R. 2000. HIP12 is a non-proapoptoticc member of a gene family including HIP1, an interacting protein with huntingtin. M a m mm Genome. 11(11): 1006-1 5.
Hackam,, A.S., Yassa, A.S., Singaraja, R., Metzler, M., Gutekunst, C-A., Gan, L., Warby, S., Wellington, C.L.,, Vaillancourt, J., Chen, N., Gervais, F.G., Raymond, L, Nicholson, D.W., and Hayden, M.R. 2000.. Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effectorr domain. J Biol Chem. 275(52):41299-308.
Wellington,, C.L., Singaraja, R., Ellerby, L, Savill, J., Roy, 5., Leavitt, B., Cattaneo, E., Hackam, A., Sharp,, A., Thornberry, N., Nicholson, D.W., Bredesen, D.E., and Hayden, M.R. 2000. Inhibiting caspasee cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and non-neuronall cells, J Biol Chem. 275(26): 19831-8.
Hackam,, A.S., Hodgson, J.G., Singaraja, R., Zhang, T., Gan, L., Gutekunst, CA., Hersch, S.M., and Hayden,, M.R. 1999. Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis inn Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin. Philos TransTrans R Soc Lond Biol Sci. 354(1386): 1047-55.
Hodgson,, J.G., Agopyan, N., Gutekunst, C-A., Leavitt, B.R., LePiane, F., Singaraja, R., Smith, D.J.,
D;; ,,-J-, M r> n^r~. , + ^L - ^ ^ \s M - , , . ; , I I - , „ , „ 4 . I I : \ / i c+~, , . — , r. n r n J r r > ^ j , , i <—
u n i o u a ,, IM., i v n _ v ^ u i u I C U I i, t\., IMCOII, J., J C H I I U L , L . , L I , / \ . J . , J H t r v e i i i , I V I . C , n u i e m u i i u , c , rMJuei , J.v_.,
Phillips,, A.G., Rubin, E.M., Hersch, S.M., and Hayden, M.R. 1999. A YAC mouse model for Huntington'ss disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.. Neuron. 23(1): 181-92.
Omori,, F., Lutzko, C, Abrams-Ogg, A., Lau, K., Gartley, C, Dobson, H., Nanji, S., Ruedy, C, Singaraja,
R.,, Li, L., Stewart, A.K., Kruth, S., and Dube, I.D. 1999. Adoptive transfer of genetically modified
thee nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease. Hum Mol Genet.Genet. 8(1):25-33.
Hough,, M.R., Reis, M.D., Singaraja, R., Bryce, D.M., Kamel-Reid, S., Dardick, I., Breitman, M l . , and Dube,, I.D. 1998. A model for spontaneous B-lineage lymphomas in lgHmu-H0X11 transgenic mice.. Proc Natl Acad So USA. 95(23): 13853-8.
Hackam,, A.5., Singaraja, R., Wellington, C.L., Metzler, M., McCutcheon, K., Zhang, T., Kalchman, M.,, and Hayden, M.R. 1998. The influence of huntingtin protein size on nuclear localization and cellularr toxicity. J Cell Biol. 141 (5):1097-105.
Wellington,, C.L., Ellerby, L.M., Hackam, A.5., Margolis, R.L., Trifiro, M.A., Singaraja, R., McCutcheon, K.,, Salvesen, G.5., Propp, S.S., Bromm M., Rowland, K.J., Zhang, T., Rasper, D., Roy, S., Thornberry, N.,, Pinsky, L., Kakizuka, A., Ross, C.A., Nicholson, D.W., Bredesen, D.E., and Hayden, M.R. 1998. Caspasee cleavage of gene products associated with triplet expansion disorders generates truncated fragmentss containing the polyglutamine tract. J Biol Chem. 273(1 5)9158-67.
Martindale,, D., Hackam, A., Wieczorek, A., Ellerby, L, Wellington, C , McCutcheon, K., Singaraja,
R.,, Kazemi-Esfarjani, P., Devon, R., Kim, S.U., Bredesen, D.E., Tufaro, F., and Hayden, M.R. 1998.
Lengthh of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.. Nat Genet. 18(2): 150-4.
Dube,, I.D., Kruth, S , Abrams-Ogg, A., Kamel-Reid, S., Lutzko, C, Nanji, S., Ruedy, C, Singaraja, R., Wild,, A., Krygsman, P., Chu, P., Messner, H., Reddy, V., McGarrity, G., and Stewart, A.K. 1996. Preclinicall assessment of human hematopoietic progenitor cell transduction in long-term marrow cultures.. Hum Gene Ther. 7(17)2089-100.
Bookk chapter
Hackam,, A., Hodgson, J.G., Singaraja, R., Zhang, T., Gan, L., Agopyan, N., Gutekunst, C-A., Hersch,, S., Hayden, M.R. Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesiss in Huntington disease in cell culture and in transgenic mice expressing mutant huntingtin.. Chapter in Glutamine Repeats and Neurodegenerative Diseases: Aspects - edited by Peterr Harper and Max Perutz. Oxford ; New York : Oxford University Press, 2001.
