Targeted Photodynamic Therapy and Photochemical Internalization of Human Head and Neck Cancer: a preclinical study in vitro and in vivo

University of Groningen

Targeted Photodynamic Therapy and Photochemical Internalization of Human Head and Neck Cancer

Peng, Wei

DOI:

10.33612/diss.167799500

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Peng, W. (2021). Targeted Photodynamic Therapy and Photochemical Internalization of Human Head and Neck Cancer: a preclinical study in vitro and in vivo. University of Groningen.

https://doi.org/10.33612/diss.167799500

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Wei Peng May, 2021

Propositions

These propositions belong to the PhD thesis entitled:

Targeted Photodynamic Therapy and

Photochemical Internalization of Human Head

and Neck Cancer

A preclinical study in vitro and in vivo

1. Targeted photodynamic therapy (Targeted PDT) with the

cetuximab-IR700DX conjugate is a potential treatment modality for human squamous cell carcinoma of the head. – This thesis

2. Epidermal growth factor receptor density is not the only determining factor for targeted PDT induced cell death of human squamous cell carcinoma of the head and neck in vitro. – This thesis

3. It is most likely that tumour destruction induced by targeted PDT with cetuximab-IR700DX is the result of a direct cell killing effect rather than vascular damage. – This thesis

4. Targeted PDT of human head and neck tumour cells in vitro and tumors in

vivo is significantly more effective with illumination at a low fluence rate. – This thesis

5. Photochemical internalisation with Foslip or Fospeg did significantly enhance the cytotoxicity of bleomycin in human squamous cell carcinoma of the head and neck in vitro when it was performed before bleomycin administration. – This thesis

6. Targeted PDT-mediated photochemical internalisation may create a

minimally invasive and highly efficient release of a biologically active molecule. – This thesis

7. While there are several chronic diseases more destructive to life than cancer, none is more feared. – Charles Mayo

8. There is only one good, knowledge, and one evil, ignorance. – Socrates

9. Scientia potentia est // Knowledge is power. – Francis Bacon