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Apoptin gene therapy in head and neck cancer Schoop, R.A.L.

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(1)Apoptin gene therapy in head and neck cancer Schoop, R.A.L.. Citation Schoop, R. A. L. (2009, December 17). Apoptin gene therapy in head and neck cancer. Retrieved from https://hdl.handle.net/1887/15030 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/15030. Note: To cite this publication please use the final published version (if applicable)..

(2) Apoptin Gene Therapy in head and neck cancer.

(3) Apoptin Gene Therapy in head and neck cancer R. A. L. Schoop Proefschrift, Universiteit Leiden ISBN: 978-90-9024869-1 © 2009 R. A. L. Schoop Kopiëren mag, vermenigvuldigen ook. Cover: Uluru and Kata Tjuta, Northern Territory, Australia. Printing: Ipskamp Drukkers BV, Enschede, The Netherlands.

(4) Apoptin Gene Therapy in head and neck cancer Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit van Leiden,    

(5)          volgens besluit van het College voor Promoties te verdedigen op donderdag 17 december 2009 klokke 16.15 uur. door. Remilio Alfonso Louis Schoop. geboren te Amsterdam in 1971.

(6) PROMOTIECOMMISSIE Promotoren:  Overige leden:. Prof.dr. R.J. Baatenburg de Jong    Prof.dr. J. Brouwer Dr. J.C. Jansen Dr. A.P.M. Langeveld. !  "  !!# #$%!&%!!%'! !%  !' (  !)!*+ SmithKline, Schering-Plough..

(7) den memoria di mi tata pasobra bo ta tin rason.

(8)

(9) Contents. Page. Chapter 1. Introduction and outline of this thesis. 9. Chapter 2. ' !+*/ 3;+  +    apoptosis in head and neck squamous cell carcinoma cell line. 23. Chapter 3. Apoptin enhances radiation induced cell death in poorly responding head and neck squamous cell carcinoma cells. 41. Chapter 4. A mouse model for oral squamous cell carcinoma 57. Chapter 5. Induced oral epithelial dysplasia in the mouse model. 71. Chapter 6. Apoptin induces apoptosis in an oral cancer mouse model. 83. Chapter 7. General discussion and summary. 101. Chapter 8. Nederlandse samenvatting. 115. Curriculum vitae. 121. Dankwoord. 123. 7.

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