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The role of abca1 in atherosclerosis: lessons from in vitro and in vivo models
Singaraja, R.R.
Publication date
2003
Link to publication
Citation for published version (APA):
Singaraja, R. R. (2003). The role of abca1 in atherosclerosis: lessons from in vitro and in vivo
models.
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Contents s
Chapterr 1: Introduction 7
PARTT I: Insights from an abcal animal model
Chapterr 2: Human ABCA1 BAC transgenic mice show increased HDL-C and ApoA-l dependant 33 effluxx stimulated by an internal promoter containing LXREs in intron 1.
Roshnii R. Singaraja, Virginie Bocher, Erick R. James, Susanne M. Clee, Lin-Hua Zhang, Blairr R. Leavitt, Bing Tan, Angela Brooks-Wilson, Anita Kwok, Nagat Bissada, Yu-zhou Yang,, Guoqing Liu, Sherrie R. Tafuri, Catherine Fievet, Cheryl L. Wellington, Bart Staelsandd Michael R. Hayden. J Biol Chem. 2001;276:33969-33979.
Chapterr 3: Alternate transcripts expressed in liver and macrophages in response to diet imply 63 tissuee specific regulation of human ABCA1
Roshnii R. Singaraja, Erick R. James, Jennifer Crim, Alu Chatterjee and Michael R. Hayden.. Manuscript in preparation
Chapterr 4: Increased activity of ABCA1 protects against atherosclerosis 85 Roshnii R. Singaraja, Catherine Fievet, Graciela Castro, Erick R. James, Nathalie Hennuyer,
Susannee M. Clee, Nagat Bissada, Jonathan C. Choy, Jean-Charles Fruchart, Bruce M. McManus,, Bart Staels and Michael R. Hayden. J Clin Invest. 2002; 110:3542.
Chapterr 5: Macrophage-specific ABCA1 overexpression inhibits atherosclerotic lesion development 103 Mirandaa Van Eck, Roshni R. Singaraja, Erick R. James, Michael R. Hayden, and Theo
J.C.. Van Berkel. Manuscript in preparation
Chapterr 6: Alterations of plasma lipids in mice via adenoviral mediated hepatic Overexpression
off human ABCA1 117 Cheryll L. Wellington, Liam R. Bunham, Steven Zhou, Roshni R. Singaraja, Henk Visscher,
Allisonn Gelfer, Colin Ross, Erick R. James, Guoquing Liu, Mary T. Huber, Yu-Zhou Yang,, Robin J. Parks, Albert Groen, Jamila Fruchart-Najib, and Michael R. Hayden. JJ Lipid Res. [epub ahead of printing]
PARTT II: ln-vitro studies of abcal function
Chapterr 7: Efflux and Atherosclerosis: The clinical and biochemical impact of variations in the 139 ABCA11 gene
Roshnii R. Singaraja, Liam R. Brunham, Henk Visscher, John Kastelein, and Michael R. Hayden.. In press, Artenoscler Thromb Vase Biol
Chapterr 8: The range of phenotypes in TD and FHA depends on severity of defects in ABCA1 163 Roshnii R. Singaraja, Henk Visscher, Erick R. James, Veronique Rigot, Yannick Hamon,
Giovannaa Chimini, and Michael R. Hayden. Manuscript in preparation
Chapterr 9: Identification and functional analysis of a naturally occurring E89K mutation in the 187 ABCA11 gene of the WHAM chicken.
Alann D. Attie, Yannick Hamon, Angela R. Brooks-Wilson, Mark P. Gray-Keller, Marcia L.. MacDonald, Veronique Rigot, Angie Tebon, Lin-Hua Zhang, Jacob D. Mulligan, Roshnii R. Singaraja, J. J. Bitgood, M. E. Cook, John J. Kastelein, Giovanna Chimini, andd Michael R. Hayden. J Lipid Res. 2 02;43:1610-1617.
Chapterr 10: Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 201 byy 9-cis-retinoic acid and 22-R-hydroxycholesterol.
Cheryll L. Wellington, Yu-Zhou Yang, Steven Zhou, Susanne M. Clee, Bing Tan, Kenichi Hirano,, Karin Zwarts, Anita Kwok, Alison Gelfer, Michel Marcil, Scott Newman, Kirsten Roomp,, Roshni Singaraja, Jennifer Collins, Lin-Hua Zhang, Albert K. Groen, Kees Hovingh,, Alison Browniie, Sherrie Tafuri, Jacques Genest Jr, John J. Kastelein, and Michaell R. Hayden. J Lipid Res. 2002;43:1939-1949.
Chapterr 11: Summary and conclusions 221
