Radiation induced lung damage

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Seppenwoolde, Y.

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2002

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Seppenwoolde, Y. (2002). Radiation induced lung damage.

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I I

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References References

A A

Abrattt RP, VWBcox PA, Smith JA. Lung cancer in patients with borderline lung functions-zonal lung perfusionn scans at presentation and lung function after high dose irradiation. Radiotier Oncol 1990:19:317-322. .

AJlavenaa C, Conroy X Aletti P. Bey P, Ledertin P. Late cardiopulmonary toxicity aller treatment for Hodgktn'ss disease. Br J Cancer 1992;65:908-912.

Allenn P, Henning G T, Ten Haken RK, Hayman JA, Martel MK. Do volume metrics predict pulmonary functionn changes in lung irradiation. Irrt J Radiat Oncol Biol Phys 2001;51:344-345.

Anscherr MS, Kong FM, Andrews K et at. Plasma transforming growth factor betel as a predictor of natationn pneumonitis. Int 4 Radiat Oncol Bnt Phys 1993;41:1029-1035.

Anscherr MS, Marks LB, Snafman TD et af. Using plasma transforming growth factor beta-1 during radiotherapyy to select patients for dose escalation. J Clin Oncol 2001 ;19:3758-3765.

Armstrongg J, Raben A, Zetefsky M et at. Promising survival with three-dimensional conforrrtaJ radiation therapyy for non-small ceH lung cancer. RadkXher Oncol 1997;44:17-22.

Armstrongg JG, Burman C, Leibel S et aJ. Three-dimensional conformai radiation therapy may improve the therapeuticc ratio of high dose radiation therapy for lur^ cartcer. Irrt J Radiat Oncol Biol Phys 1993;26:685-689. .

Arriagadaa R, Current strategies for radiation therapy in non-smalt cell lung cancer. Chest 1997;112:209S-213S. .

Arriagadaa R, Le Chevalier T. Quoix £ et at. ASTRO plenary: Effect of chemotherapy on locally advanced non-smaDD cell King carcinoma: a randomized study of 353 patients. GETCB, FNCLCC and the CEBI triafcts.. Irrt J Radiat Oncot Biol Phys 1991;20:1183-1190.

B B

Bakheett SM, Sateem M, Powe J et al. F-18 ftucrodeoxygfucose chest uptake in lung inflammation and infection.. CJin Nucl Med 2000;25:273-278.

Batterr JM, Lam KL, McGinn CJ, Lawrence TS, Ten Haken RK. Improvement of CT-based treatment-planningg models of abdominal targets using static exhale imaging. Int J Radiat Oncol Biot Phys 1998;41:939-943. .

Batterr JM, Ten Haken RK, Lawrence TS, Lam XL, Robertson JM. Uncertainties in CT-based radiation therapyy treatment planning associated with patient breathing. Int J Radiat Oncol Biol Phys 1996;36 :167-174. .

Bell A, BarteÜnk H, Vijlbrief RE, Lebesque JV. Transfer errors of planning CT to simulator a possible sourcee of setup inaccuracies? Radiother Oncol 1994;31:178-180.

Bell A, van Berk M, Bartelink H, Lebesque JV. A verification procedure to improve patient set-up accuracy usingg portal images. Radtother Oncol 1993;29:253-260.

Bekterboss JSA, De Jaeger K, Heemsbergen WD, Baas P, Seppenwooide Y, Boersma U, Lebesque JV. Interimm analysts of a phase l/ll dose escalation trial In Non-Smalt Cell Lung Cancer (NSCLC) Using Three-Dimensionall Conformai Radiotherapy (3D-CRT). Irrt J Radiat Oncol Biol Phys 2001;

Bekterboss JSA De Jaeger K, Baas P, Lebesque JV. pose escalation in NSCLC using three-dimensional conformaii radiotherapy (3DCRT). Lung Cancer 2000;29, Suppf. 1 (545):161.

Bekterboss JSA, Lebesque JV, Bariflot I. Normal tissue complication probabilities for irradiation of NSCLC patientss with and without elective nodal irradiation. Lung Cancer 1997;18:126

Bentzenn SM, Skoczylas JZ, Bemfer J. Quantitative clinical radtobiology of early and late lung reactions. Intt J Radiat Biol 2000;78:453-462.

Bentzenn SM, Skoczylas JZ, Overgaard M, Overgaard J. Radiotherapy-related lung fibrosis enhanced by tamoxifen.. J Natl Cancer Inst 1996;88:918-922.

Bjermerr L, Cai Y, NHsson K, HeKstrom S, Henriksson R. Tobacco smoke exposure suppresses radiation-inducedd inflammation in the lung: a study of bronchoatveolar lavage and ultrastiuctural morphology in the ratt Eur Respir J 1993;6:1173-1180.

(5)

References References

Bjermerr L, Franzen L, Uttbnand B ot al. Effects of smoking and irradiated volume on inflammatory responsee in the lung of irradiated breast cancer patients evaluated with bronehoalveolar lavage. Cancer Ress 1990;50:2027-2030.

Bjermerr L, Haiigren R, NHsson K et al. Radiation-induced increase in hyaluronan and fibronectin in bronchoarveofarr lavage fluid from breast cancer patients is suppressed by smoking, Eur Resptr J 1992;5:785-790. .

Blomgrenn H, Lax I, Naslund I, Svanstrom R. Stereotactic high dose fraction radiation therapy of extracraniall tumors using an accelerator. Clinical experience of the first thirty-one patients. Acta Oncol 1995;34:861-870. .

Boersmaa LJ, Damen EM, de Boer RW et a l Dose-effect relations for local functional and structural changess of the lung after irradiation for maHgnant lymphoma. Radiother Oncol 1994;32:201-209. Boersmaa LJ, Damen EM, de Boer RW et al. Estimation of overall pulmonary function after irradiation using dose-effectt relations for local functional injury. Radiother Oncol 1995;36:15-23.

Boersmaa U , Damen EM, de Boer RW et at. A new method to determine dose-effect relations for local lung-functionn changes using correlated SPECTand CT data. Radiother Oncol 1993;29:110-116. Boersmaa LJ, Damen EM, de Boer RW et al. Recovery of overall and local lung function loss 18 months afterr irradiation for malignant lymphoma. J Clin Oncol 1996;14:1431-1441.

Bolligerr CT, Wyser C, Roser H, Soler M, Perruchoud AP. Lung scanning and exercise testing for the predictionn of postoperative performance in lung resection candidates at increased risk for complications. Chestt 1995;108:341-348.

Breurr K, Cohen P, Schwetsguth O, Hart AM. Irradiation of the lungs as an adjuvant therapy in the treatmentt of osteosarcoma of the limbs. An E.O.R.T.C- randomized study. Eur J Cancer 1978;14:461-471. Bricee P, Tredantel J, Monsuez JJ et al. Cardiopulmonary toxicity after three courses of ABVD and mediastinall irradiation in favorable Hodgkin's disease. Ann Oncol 1991 ;2 Suppl 2:73-76. .

Burmann C, Kuteher GJ, Emami B, Gottein M. Fitting of normal tissue tolerance date to an anarytic function. Intt J Radiat Oncol Biol Phys 1991;21:123-135.

Buryy T, Barreto A, Daenen F et al. Fiuorine-18 deoxyglucose positron emission tomography for the detectionn of bone metastases in patients with non-small cell lung cancer. Eur J Nucl Med 1998^5:1244-1247. .

Byhardtt RW. The evolution of Radiation Therapy Oncology Group (RTOG) protocols for nonsmatl cefl hmg cancer.. Int J Radiat Oncol Biol Phys 1995;32:1513-1525.

C C

Chann R, He, Y, Haque A, Zwischenberger J . Computed Tctrtographic-Pathologic Correlation of Gross Tumorr Volume and Clinical Target Volume in Non-Small Cell Lung Cancer. Arch Pathol Lab Med 2001;125:1469-1472. .

Changg LT. A method for attenuation correction in radionuclide computed tomography. IEEE trans On Nuclearr science 1978;25: 638-643.

Chenn OS. Weinhous MS, Deibel FC, Ciezki JP, Macklis RM. Fluoroscopic study of tumor motion due to breathing:: facilitating precise radiation therapy for lung cancer patients. Med Phys 2001 a;28;1850-1856. Chenn Y, Rubin P, Wtfiiams J et al. Circulating IL-6 as a predictor of radiation pneumonitis. Int J Radiat Oncoll Biol Phys 2001 b;49:641-648.

Choii NC, Kanarek DJ. Toxicity of thoracic radiotherapy on pulmonary function in lung cancer. Lung Cancer 1994;100 Suppl 1:S219-30:

Choii NC, Kanarek DJ, Kazemi H. Physiologic changes in pulmonary function after thoracic radiotherapy forr patients with lung cancer and a role of regional pulmonary function studies m predicting post-radiotherapyy pulmonary function before radiotherapy Cancer Treatment Sympos 1985:2:119-130. Claytonn D. Hills M. Chapters 3 and 13. In: Statistical models in epidemiology New York: Oxford University Press;; 1993. p.

ColHss CH, Steel GG. Lung damage in mice from cyclophosphamide and thoracic irradiation: the effect of timing.timing. Int J Radiat Oncol Biol Phys 1983;9:685-689.

(6)

References s

Coxx JD, Azamia N, Byhardt RW et aL A randomized phase L/11 trial of hyperfractionated radiation therapy withh total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or aqua) to 69.6 Gy in favorablefavorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung CTrcb^^ off Radiation Therapy Oncology Group 83-11. J CKn Oncol 1990;8:1543-1555.

Coxx JD, Pa|ak TF, AsbeH 3 et al. Interruptions of high-dose radiation therapy decrease tong-term survival off favorable patients with unresectable non-small cell carcinoma of the lung: analysis of 1244 oases from 33 Radiation Therapy Oncology Group (RTOG) trials. Int J Radial Oncol Biol Phys 1993;27:493-498. Currann WJJ, Moktofsky PJ, SoHn U. Observations on the predictive value of perfusion lung scans on post-irradiationn pulmonary function among 210 patients with bronchogenic carcinoma, tnt J Radiat Oncol Biol Physs 1992;24:31-36.

Currann WJJ, Moldofeky PJ, Sotin LJ. Analysis of the influence of elective nodal irradiation on postfnadjationn pulmonary function. Cancer 1990;65:2488-2493.

D D

Damenn EMF, Muller SH, Boersma U, de Boer RW, Lebesque JV. Quantifying local lung perfusion and ventilationn using correlated SPECT and CT data. J Nud Med 1994a;35:784-792.

Damenn EMF, Boersma LJ, de Boer RW, Muller SH, Lebesque JV Predicting overall lung function toss basedd on clinically determined local dose-effect relations and the full 3-dimenstonal dose distribution. Proceedingss of the Xlth International Conference on the use of Computers in Radiation Therapy, Manchester,, 20-24 March, 1994.Eds AR Hounse», JM Wilkinson and PC Williams, 204,1994b;

dee Boer HC, van Somsen de Koste JR, Senan S, Visser AG, Heijmen BJ. Analysis and reduction of 3D systematicc and random setup errors during the simulation and treatment of lung cancer patients with CT-basedd external beam radiotherapy dose planning. Int J Radiat Oncol Biol Phys 2001 ;49:657-868. Dosoretzz DE, Katin MJ, BHtzer PH et al. Medicaly Inoperable Lung Carcinoma: The Role of Radiation Therapy.. Semin Radiat Oncof 1996;6:98-104.

Dubrayy B, Henry-Amar M, MeerwaJdt JH et al. Reflation-induced lung damage after thoracic irradiation forfor Hodgkin's disease: the rote of fractionation. Radtother Oncol 1995;36:211-217.

Dwamenaa BA, Sonriad SS, AngobaJdo JO, Wahl RL. Metastases from non-smali cell lung cancer: mediastinall staging in the 1990s-meta-analytic comparison of PET and CT. Radiology 1999;213:530-536.

E E

Eisbruchh A, Ten Haken RK, Kim HM, Marsh LH, Ship JA. Dose, volume, and function relationships in parotidd salivary glands following conformai and intensity-modulated irradiation of head and neck cancer. Intt J Radiat Oncol Btot Phys 1999;45:577-587.

Ekbergg I, Hoimoerg O, Wfttgren L, Bjeikengren G, Landberg T. What margins should be added to the clinicall target volume in radiotherapy treatment planning for lung cancer? Radtother Oncol 1996;48:71-77. Ekstrandd KE, Barnes WH. Pitfalls rn the use of high energy X rays to treat tumors in the lung. Int J Radiat Oncoll Biol Phys 1990;18:249-252.

Emamii B, Lyman J, Brown A et at. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Bioll Phys 1991;21:109-122.

Engelsmann M, Damen EMF, De Jaeger K. van Ingen KM, Mijnheer BJ. The effect of breathing and set-up errorss on the cumulative dose to a lung tumor. Radtother Oncol 2001 a;60:95-105.

Engelsmann M, Damen EM, Koken PW et al. Impact of simple tissue irtbomogenefty correction algorithms onn conformaJ radiotherapy of lung tumours. Radtother Oncol 2001b;60:299-309,

Engelsmann M, Remeijer P, van Heric M et al. Field size reduction enables Sso-NTCP escalation of tumor controll probability for irradiation of tung tumors. Int J Radiat Oncol Btoi Phys 2u01c,51:1290-1298. Erasmuss JJ, Patz EF, Jr., McAdams HP et al. Evaluation of adrenal masses in patients with bronchogenic carcinomaa using 18F-fluorodeoxyglucose positron emission tomography. AJR Am J Roentgenol 1997;168:1357-1360. .

Erdii YE, Mawlawi O, Larson SM et al. Segmentation of lung lesion volume by adaptive positron emission tomographyy image thresholding. Cancer 1997;80:2505-2509.

(7)

F F

Fann M, Maries I, Und P et al. Relating radiation-Induced regional lung injury to changes in pulmonary functionn tests. Int J Radiat Oncol Bio* Phys 2001a;51:311-317.

Fann M, Marks LB, Hollis D et at. Can we predict radiation-induced changes in pulmonary function based onn the sum of predicted regional dysfunction? J Clin Oncol 2001b; 19:543*550.

Fazioo F, Pratt TA, McKenzie CG, Steiner RE. Improvement in regional ventilation and perfusion after radiotherapyy for unresectable carcinoma of the bronchus. AJR Am J Roentgenol 1979;133:191-200. Fraasss BA, Mc Shan DL. 3-D Treatment planning: I. Overview of a clinical planning system. In: Bruinvis IAD,, van der Gtessen PH, and Wfttkamper FW, editors. Proceedings of the Ninth International Conference onn the Use of Computers in Radiation Therapy. Amsterdam: North Hofland Press; 1987a. p. 273-276 Fraasss BA, McShan DL. 343 Treatment planning: I. Overview of a clinical planning system. Scheveningen, Thee Netherlands: Amsterdam: North Hofland Press; 1987b.

Franzenn L, Bjermer L, Henriksson R, Uttbrand B, Nilsson K. Does smoking protect against radiation-inducedd pneumonitis? Int J Radiat Biol 1989;56:721-724.

Fuu X, Huang H, Bentel G el al. Predicting the risk of symptomatic radiation-inducedd lung injury using both thee physical and biologic parameters V(30) and transforming growth factor beta. Int J Radiat Oncol Bk» Physs 2001;50:899-908,

G G

Gagtiardii G, Bjohle J, Lax I et al. Radiation pneumonitis after breast cancer irradiation: analysis of the complicationn probability using the relative seriaJity model. Int J Radiat Oncol Biol Phys 2000;46:373-381. Garipagaogluu M, Munley MT. Hollis D et al. The effect of patient-specific factors on radiation-induced regionall lung injury, lnt J Radiat Oncol Etol Phys 1999;45:331-338.

Giordanoo A, Cafcagni ML, Meduri G, Valente S. Gaiil G. Perfusion lung scintigraphy for the prediction of posttobectomyy residual pulmonary function. Chest 1997;111:1542-1547.

Giraudd P, Antoine M, Larrouy A et al. Evaluation of microscopic tumor extension in non-small-cetl lung cancerr for three-dimensional conformal radwtirerapy plannirig. tnt J Radiat Oncol Bk>l Phys 2O0O;48:1015-1024. .

Goldmann SM, Freeman LM, Ghossein NA. Sarrfilippo U . Effects of thoracic irradiation on pulmonary arteriall perfusion in man. Radiology 1969;93:289-296.

Grahamm MV, Drzymata RE, Jain NL, Purdy JA. Confinnation of dose-volume histograms and normal tissue compJtcationprobabilrtyy calculations to predict pulmonary complications after radiotherapy for lung cancer. lnt.J.Radiat.Oncol.Biol.Phys.. 1994;30(Suppl.):198

Grahamm MV, Purdy JA, Emami B et al. Clinical dose-volume histogram analysis for pneumonitis after 3D treatmentt for non-small cell lung cancer (NSCLC). lnt J Radiat Oncol Biol Phys 1999;45:323-329.

Grahamm MV, Purdy JA, Emami B, Matthews JW, Harms WB. Preliminary resultss of a prospective trial using threee dimensional radiotherapy for Hmg cancer, tnt J Radiat Oncol Biol Phys 1995;33:993-1000.

H H

Hartleyy J, Debois MM, Mah D et al. Deep inspiration breath-hold technique for lung tumors: the potential valuee of target immobilization and reduced lung density in dose escalation, lnt J Radiat Oncol Biol Phys 1999:45:603^611. .

Hardmann PD. Tweeddate PM, Kerr GR, Anderson ED, Rodger A. The effect of pulmonary function of local andd toco-regional irradiation for breast cancer. Radiother Oncol 1994;30:33-42.

Haymann JA, Martel MX, Ten Haken RK et al. Dose Escalation in Non-Small-Cell Lung Cancer Using Three-Dimenstona!! Conformal Radiation Therapy: Update of a Phase I Trial. J Clin Oncol 2001:19:127-136. .

Hrafnketesonn J, Nilsson K, Soderberg M. Tolerance of radiotherapy combined with adjuvant chemotherapy inn breast cancer. Acta Oncol 1987;26:269-272.

(8)

References s

I I

(CRUU Report 50. Presaging, recording, and reporting photon beam therapy, International Commissionn on Radiationn Unite and Measurement Washington D.C. 1993.

ICRUU Report 62 (Supplement). Prescribing, recording, and reporting photon beam therapy, International Commissionn on Radiation Units and Measurement Washington D.C. 1999.

J J

Jacksonn A, Kuteher GJ, Yorke ED. Probability of radiation-induced compfications for normal tissue© with parallell architecture subject to non-uniform irradiation. Med Phys 1993;20:613-625.

Jacksonn A, Ten Haken RK, Robertson JM et a). Analysis of cHnical complication data for radiation hepatitis usingg a parallel architecture model. Int J Radiat Oncol Biol Phys 1995;31:883-891.

Janssen-Heijnenn ML, Gatta G, Forman D, Capocaocia R, Coebergh JW. Variation in survival of patients withh King cancer in Europe, 1985-1989. Eur J Cancer 1998;34:2191 -2196.

Janssen-Heijnenn ML, van Dgck JA, Slesling S, Schipper RM, Damhuis RA. [Lung cancer in the Netherlandss in the period 1989-1997: the epidemic is not over yet]. Ned Tijdschr Geneeskd2001;145:419-423. .

Jensenn BV, Carisen NL, Nissen NI. Influence of age and duration of follow-up on lung function after combinedd chemotherapy for Hodgkin's disease. Eur Respir J 1990;3:1140-1145.

Johanssonn S, Bjermer L, Franzen L, Henriksson R. Effects of ongoing smoking on me development of

radiation-inducedradiation-induced pneumonitis In breast cancer and oesophagus cancer patients. Radiother Oncol 1998;49:41-47. .

K K

Kaffff V, Hicks RJ, MacManus P et al. Clinical Impact of (18)F Fluorodeoxyglucose Positron Emission Tomographyy in Patients With Non-Small-Cell Lung Cancer A Prospective Study. J CHn Oncol 2001;19:111-118. .

Kawabee J, Okamura T, Shakudo M et al. Thattium and FDG uptake by atelectasis with bronchogenic carcinoma.. Ann Nud Med 1999:13^73-276.

Keilmann P, Agren A, Brahme A. Tumour and normal tissue responses to fractionated non-uniform dose delivery.. Int J Radiat Biol 1992;62:249-262.

Kesslerr ML, Kim JJH, McShan DL, Fraass BA. A general framework for interactive and automated treatmentt plan optimization, part 1: evatuators, modifiers and costJets. Med.Phys. 1998;25:A118

Kimm DJ, Murray BR, Halperin R, Roa WH. HeW-breath self-gating technique for radiotherapy of non-smatl-ceHH lung cancer a feasibility study. Int J Radiat Oncol Biol Phys 2001;49:43- 49.

Kimm JJH, Dogan N, McShan DL, Kessler ML An AVS-based system for optimization of conformal therapy treatmentt plans. International Advanced Visual Systems User and Developer Conference 1995:417-423. Kitamuraa K, Shirato H, Shrmizu S. Migration of the internal fiducial gold marker implanted onto prostate and liverr treated with real-time tumor-tracking radiation treatment (RTRT). Int J RadUrt Oncol Biol Phys 2000;488 (3S):343-344.

Knudsonn RJ, Kattenbom WT, Burrows B. The effects of cigarette smoking and smoking cessation on the carbonn monoxide diffusing capacity of the king in asymptomatic subjects. Am Rev Respir Dis 1989;140:645-651. .

Kuboo HD, Len PM, Minohara S, Mostafavi H. Breathing-synchronized radiotherapy program at the Universityy of California Davis Cancer Center. Med Phys 2000;27:346-353.

Kuteherr GJ, Burman C. Calculation of oompflcation probability factors for non-uniform normal tissue irradiation:: the effective volume method. Int J Radiat Oncol Biol Phys 1989;16:1623-1630.

Kwaa SL, Lebesque JV, Theuws JC et al. Radiation pneumonitis as a function of mean lung dose: an analysiss of pooled data of 540 patients. Int J Radiat Oncol Biol Phys 1998a;42:1-9.

(9)

References References

Kwaa S t , Theuws JC. van Herk M et al. Automatic three-dimensional matching of CT-SPECT and CT-CT too localize lung damage after radiotherapy. J Nud Med 1998b;39:1074-1080.

Kwaa SL, Theuws JC, Wagenaar A et al. Evaluation of two dose-volume histogram reduction models for thee prediction of radiation pneumonitis. Radiother Oncol

1998c;48:61-69-L 1998c;48:61-69-L

Lagrangee JL, Thyss A, Caldani C et al. Toxicity of a combination of ABVD chemotherapy and mediastinal irradiationn for Hodgkin's disease patients with massive initial mediastinal involvement. Bull Cancer 1988;75:801-806. .

Lebesquee JV, Keus RB. The simultaneous boost technique: the concept of relative normalized total dose. Radiotherr Oncol 1991;22:45-55.

Linkk JM. Simultaneous duaf-radionuctide imaging: are the images trustworthy? Eur J Nud 1996:23:1289-1291. .

Lujann AE, Larsen EW, Batter JM, Ten Haken RK. A method for incorporating organ motion due to breathingg Into 3 0 dose calculations. Med Phys 1999;26:715-720.

Lymann JT. Complication probability as assessed from dose-volume histograms. Radiat Res Suppl 1985;8:S13-S19. .

M M

Macc Manus MP, Hicks RJ, BaK DL et a). F-18 fluorodeoxyglucose positron emission tomography staging inn radical radiotherapy candidates with nonsmail cell king carcinoma: powerful correiation with survival andd high impact on treatment. Cancer 2001 ;92:886-895.

Maciejewskii B, Taylor JM, Withers HR. Alpha/beta value and the importance of size of dose per fraction forr late complications in the supraglotttc larynx. Radiother Oncol 1986;7:323-326.

Magerass GS, Mohan R. Application of fast simulated annealing to optimization of conformal radiation treatments.. Med Phys 1993;20:639-647.

Mann D. Hartley J, Rosenzweig KE et al. Technical aspects of the deep inspiration breath-hold technique inn the treatment of thoracic cancer. Int J Radiat Oncol Biol Phys 2000;48:1175-1185.

Mann K, Keane TJ, Van Dyk J et al. Quantitative effect of combined chemotherapy and fractionated radiotherapyy on the incidence of radiation-induced lung damage: a prospective clinical study. Int J Radiat Oncoll Biol Phys 1994;28:563-574.

Mann K, Van Dyk J, Keane T, Poon PY. Acute radiation-induced pulmonary damage: a clinical study on the responsee to fractionated radiation therapy Int J Radiat Oncol Biol Phys 1987;13:179-188.

Majidd OA, Lee S, Khushatani S, Seydel HG. The response of atelectasis from lung cancer to radiation therapy.. Int J Radiat Oncol Biol Phys 1986;12:231-232.

Manlyy BFJ. Randomization and Monte Carlo methods in biology London, U.K.: Chapman & Hall; 1991. Markss LB. The pulmonary effects of thoracic irradiation. Oncology (Huntingt) 1994;8:89-106.

Markss LB, Fan M, Clough R et al. Radiation-induced pulmonary injury: symptomatic versus subclinical endpoints.. Int J Radiat Biol 2000a;76: 469-475.

Markss LB, Halperin EC, Prosnitz LR et al. Post-mastectomy radiotherapy following adjuvant chemotherapy andd autologous bone marrow transplantation for breast cancer patients with greater than or equal to 10 positivee axillary lymph nodes. Cancer and Leukemia Group B. Int J Radiat Oncol Biol Phys 1992:23:1021-1026. .

Markss LB, Hollis D, Muniey M et al. The role of lung perfusion imaging in predicting the direction of radiation-inducedd changes in pulmonary function teste. Cancer 2000b;88:2135-2141.

Markss LB, Muniey MT, Bentet GC et al. Physical and biological predictors of changes in whote-lung functionn following thoracic irradiation. Int J Radiat Oncol Bid Phys 1997a;39:563-570.

Markss LB, Muniey MT, Spencer DP et al. Quantification of radiation-induced regional lung injury with perfusionn imaging. Int J Radiat Oncol Biol Phys 1997 b; 38:399-409.

(10)

nöW/tiflCSS S

Markss LB, Sherouse GW, Muntey MT, Bentei GC, Spencer DP. Incorporation of functional status into dóse-volumee analysis. Med Phys 1999;26:196-199.

Markss LB, Spencer DP, Bentei GC et al. Utility of SPECT lung perfusion scans in minimizing and assessingg me physiologic consequences tfth^

668. .

Markss LB, Spencer DP, Sherouse GW et a). The role of three dimensional functional king imaging in radiationn treatment planning: the functional dose-volume histogram, kit J Radiat Oncol Biol Phys 1995;33:65-75. .

Martell MK, Ten Haken RK, Hazuka MB et at. Estimation of tumor control probability model parameters fromS-Ddoeedtstributiofisofnon^ ^

Martell MK, Ten Haken RK, Hazuka MB et at. Dose-volume histogram and 3-D treatment planning evaluationn of patients with pneumonitis . Int J Radiat Oncol Bio» Phys 1994;28:575-561.

McAdamss HP, Erasums JJ, Patz EF, Goodman PC, Coleman RE. Evaluation of patients with round atelectasiss using 2-{18F]-fluoro-2-deoxy-r>glucose PET. J Comput Assist Tomogr 1998;22:601-604. McDonaldd S, Rubin P, PNIUps TL, Marks LB- Injury to the lung from cancer therapy: dfnicai syndromes, measurabiee endpornts, and potential scoring systems. Int J Radiat Oncol Biol Phys 1995;31:1187-1203. McGibneyy C, HoJmberg O, McClean B et a). Dose escalation of chart in non-small ceR lung cancer is three-dimensionall conforrnal radiation therapy really necessary? tnt J Radiat Oncol Biol Phys 1999;45:339-350. .

McLoudd TO, Bourgouin PM, Greenberg RW et al. Bronchogenic carcinoma: analysis of staging in the mediastinumm with CT by correlative lymph node mapping and sampling. Radiology 1992;182:319-323-Mehtaa M, Scrimger R, Maekie R et at. A new approach to dose escalation En non-small cell lung cancer. Intt J Radiat Oncol Biol Phys 2001 ;49:23-33.

Mtnoharaa S, Kanai T, Endo M, NodaK KanazawaM. Respiratory gated irradiation system for heavy-ion radiotherapy,, mt J Radiat Oncol Biol Phys 2000;47:1097-1103.

Moerlandd MA. Roeslnk JM, Ternaard CHJ, Battermann JJ. Modelling of parotic salivary gland function fottowmgg trradiaton of head and neck cancer. Radiother.Oncol 2000;56(SuppL1):115:

Mohann R, Mageras GS, Baldwin B et at, CtNcaRy relevant optimization of 3-D conformal treatments. Med Physs 1992;19:933-944.

Morgann GW, Freeman AP, McLean RG, Jarvie BH, Giles RW. Late cardiac, thyroid, and pulmonary sequelaee of mantle radiotherapy for Hodgkin's disease. Int J Radiat Oncol Biol Phys 1985;11:1926-1931.

N N

Nestlee U, Walter K. Schmidt S et al. 18F-deoxyglucose positron emission tomography (FDG-PET) for the planningg of radiotherapy in lung cancer high impact in patients with atelectasis. Int J Radiat Oncol Biol Physs 1999;44:593-597.

Newcembb CH, Van Dyk J, HiH RP. Evaluation of isoeffect formulae for predicting radiation-induced lung damage.. Radkimer Oncol 1993;26:51-63.

Newtonn KA, Spittle MP. An analysis of 40 cases treated by total thoracic irradiation. Cfin Radiol 1969;20:19-22. .

Niemterkpp A. Reporting and analyzing dose distributions: a concept of equivalent uniform dose. Med Phys 1997;24:103-110. .

Niemierkoo A. A generalized concept of Equivalent Uniform Dose (EUD). Med.Phys 1999;26(6):1100. Niemterkoo A, Goitein M. Modeling of normal tissue response to radiation: the critical volume model. Int J Radiatt Oncol Biol Phys 1993;25:135-145.

Noreenn EW. Computer intensive methods for testing hypothesis. New York: John Wiley & Sons; 1989.

O O

Oetrell D, Schraube P. Hensley F et al. Estimation of pneumonitis risk in three-dimensional treatment planningg using dose-volume histogram analysis. Int J Radiat Oncol Biol Phys 1995;33:455-460.

(11)

Ofiaraa L, Roman T, Schwartzman K, Levy RD. Local determinants of response to endobronchial high-dose ratee brachytherapy in bronchogenic carctnoma. Chest 1997;112:946-953 .

Oharaa K, Okumura T, Akisada M et al. irradiation synchronized with respiration gate, int J Radiat Oncol Bioll Phys 1989;17:853-857.

Oldhamm M, Webb S. The optimization and inherent limitations of 30 conformal radiotherapy treatment planss of the prostate. Br J Radiol 1995;68:882-893.

P P

Perezz CA, Bauer M, Edelstein S, Gillespie BW, Birch R. Impact of tumor control on survival in carcinoma off the lung treated with irradiation (published erratum appears in Int J Radiat Oncol Biol Phys 1986 Nov;12(11):2057].. kit J Radiat Oncol Biol Phys 1986;12:539-547.

Perezz CA, Pajak TF, Rubin P et al. Long-term observations of the patterns of failure in patients with unresectablee non-oat ceil carcinoma of the lung treated with definitive radiotherapy. Report by the Radiationn Therapy Oncology Group. Cancer 1987;59:1874-1881.

Pietermann RM, van Putten JW, Meuzeiaar JJ et al. Preoperative staging of non-smaH-cell lung cancer with positron-emissionn tomography. N Engl J Med 2000;343:254-261.

Pigottt KH, Saunders Ml. The long-term outcome after radical radiotherapy for advanced localized non-smalll cell carcinoma of the lung. Clin Oncol (R Coll Radiol) 1993;5:350-354.

Q Q

Quanjerr PH, Anderson LH, Tammeling GJ. Clinical respiratory physiology. Bull Eur Physiopathol Respir 1983;19:11-21. .

Quintt LE, Francis IR, Wahl RL, Gross BH, Glazer GM, Preoperative staging of non-small-ceil carcinoma off the lung: imaging methods. AJR Am J Roentgenol 1995;164:1349-1359.

R R

Rabb GT, Ivins JC, Chads DSJ, Cupps RE, Pritchard DJ. Elective whole lung irradiation in tire treatment of osteogenicc sarcoma. Cancer 1976;38:939-942 .

Reddyy SP, Marks JE. Total atelectasis of the lung secondary to malignant airway obstruction. Response too radiation therapy. Am J Clin Oncol 1990;13:394400.

Robertsonn JM. Ten Haken RK, Hazuka MB et al. Dose escalation for non-small cell lung cancer using conformall radiation therapy. Int J RacUat Oncol Biol Phys 1997;37:1079-1085.

Robnettt TJ, Machtay M, Vines EF et al. Factors predicting severe radiation pneumonitis in patients receivingg definitive chemoradiation for lung cancer. Int J Radiat Oncol Biol Phys 2000;48:89-94. Rosenzweigg KE, Hartley J, Mah D et al. The deep inspiration breath-hold technique in the treatment of inoperablee non-smaH-cell lung cancer. Int J Radiat Oncol Biol Phys 2000;48:81-87.

Rosss CS, Hussey DH, Pennington EC, Stanford W, Doornbos JF. Analysis of movement of intrathoracic neoplasmss using ultrafast computerized tomography. Int J Radiat Oncol Biol Phys 1990;18:671-677. Roswftt B, White DC. Severe radiation injuries of the lung. AJR Am J Roentgenol 1977;129:127-136. Rubensteinn JH, Richter MP, Moldofsky PJ. Solin Li. Prospective prediction of post-radiation therapy lung functionn using quantitative lung scans and pulmonary function testing. Int J Radiat Oncol Biol Phys 1988;15:83-87. .

S S

Samsonn MJ, van Sornsen de Koste JR, de Boer HCetal. An analysis of anatomic landmark mobility and setupp deviations In radiotherapy for lung cancer. Int J Radiat Oncol Biol Phys 1999;43:827-832.

Sansoress RH, Pare PD, Abboud RT. Acute effect of cigarette smoking on the carbon monoxide diffusing capacityy of the lung. Am Rev Respir Dis 1992;146:951-958.

(12)

Sasakii R, Soejima T, Matsumoto A et al. Clinical significance of serum pulmonary surfactant proteins a andd d for the early detection of radiation pneumonitis. Int J Radiat Oncol BkA Phys 2001 ;50:301-3Q7. Sauerr OA, Shepard DM, Machte TR. Application of comtrair^ c^mizatwn to rao^otherapy planning. Med Physs 1999;26:2359-2366.

Saunderss Ml, Dische S. Barrett A et a). Randomised multicentre trials of CHART vs conventional radiotherapyy in head and neck and non-small-cefl kmg cancer, an interim report CHART Steering Committee.. Br J Cancer 1996;73:1455-1462.

Sausee WT, Scott C, Taylor S et a\. Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperativee Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regtonaBy advanced, unresectablee non-smaK-cell tung cancer. J Natl Cancer Inst 1995;67:198-205.

Schaafsmaa J, Coy P. The effect of radiotherapy on the survival of non-smaH cell lung cancer patients. Int JJ Radiat Oncol Biol Phys 1998:41291-298.

Scnaake-Komngg C, Schuster-Uitternoeve L, Hart G, Gonzalez GD. Prognostic factors of inoperable localizedd king cancer treated by high dose radiotherapy. Int J Radiat Oncol Biol Phys 1983;9:1023-1028. Schaake-Koningg C. van den BW, Dalesio O et al. Effects of concomitant ctsptetin and radiotherapy on inoperablee non-small-cell lung cancer. N Engl J Med 1992;326:524-530.

Schibtraa C, Meertens H. Calculation of the uncertainty in complication probability for various dose-responsee models, applied to the parotid gland. Int J Radiat Oncol Bio) Phys 2001;50:147-158.

Scottt AM, Current status of positron emission tomography in oncology. Intern Med J 2001;31:27- 36. Senann S, van Somsen dK, Samson M et al. Evaluation of a target contouring protocol for 3D conformal radiotherapyy in non-smaH cell lung cancer. Radiother Oncol 1999;53:247-255.

SeppenwookJee Y, Lebesque JV. Partial irradiation of the lung. Semin Radiat Oncol 2001a;11:247-258. Seppenwooldee Y, Muller SH, Theuws JC et al. Radiation dose-effect relations and local recovery in perfusionn for patients with non-smafl-ceU lung cancer, int J Radiat Oncol Biol Phys 2000;47:681-690. Seppenwooldee Y, Shirato H, Kitamura K et at 3D tumor motion in rung due to breathing and heartbeat, measuredd during reaJ-time tumor tracking radiation therapy. Int J Radiat Oncol Biol Phys 2001b;51:24, Shimizuu S, Shirato H, Kagei K et at Impact of respiratory nrovement cm trw computed ^

off small lung tumors in three-dimensional (3D) radiotherapy. Int J Radiat Oncot Biol Phys

2000;46:1127-1133. .

Shimizuu S, Shirato H, Ogura S et ai. Detection of lung tumor movement in real-time tumor-tracking radiotherapy.. Int J Radiat Oncol Biol Phys 2001;51:304-310.

Shiratoo H, Shimizu S, Kitamura K et al. Four-dimensional treatment planning and fluoroscopic real-time tumorr tracking radiotherapy for moving tumor. Int J Radiat Oncol Biol Phys 2000a;48:435-442.

Shiratoo H, Shimizu S, Kunieda T et al. Physical aspects of a real-time tumor-tracking system for gated radiotherapy.. Int J Radiat Oncol Biol Phys 2000b;48:1187-1195.

Shiratoo H, Shimizu S, Shimizu T, Nishioka T, Miyasaka K. Real-time tumour-tracking radiotherapy. Lancet 1999;353:133M332. .

Siemannn DW, HOI RP, Bush RS. Smoking: the influence of carboxyhemogtobin (HbCO) on tumor oxygenationn and response to radiation. Int J Radiat Oncol Biol Phys 1978;4 .-657-662.

Skoczytass JZ, Bentzen SM, Overgaan! M, Overgaard J. Time course of radiological rung density changes afterr postmastectomy radiotherapy. Acta Oncol 2000;39:181-187.

Stevenss CW, Munden RP, Forster KM et al. Respiratory-driven lung tumor motion is independent of tumor size,, tumor location, and pubnonary function. Int J Radiat Oncol Biol Phys 2001 ;51:62- 68.

T T

Taghiann AG, Assaad SI, Niemierko A et al. Risk of pneumonitis in breast cancer patients treated with radiationn therapy and combination chemotherapy with paclitaxel. J Natl Cancer Inst 2001;93:1806-1811. Tenn Haken RK, Dawson LA, McGinn CJ, Lawrence TS. I^tenriination of moclelpararrraters for description off radiation induced liver disease, Radiother.Oncol 2000;56(Supp).1):426:

(13)

Tenn Haken RK. Martel MK, Kessler ML et al. Use of Veff and teo-NTCP in the implementation of dose escalationn protocols. Int J Radiat Oncol Biol Phys 1993;27:689-695.

Theuwss JC, Kwa SL, Wagenaar AC et al. Dose-effect relations for early local pulmonary injury after irradiationn for malignant lymphoma and breast cancer. Radiother Oncol 1998a;48:33-43.

Theuwss JC, Kwa SL, Wagenaar AC et al. Prediction of overall pulmonary function loss hi relation to the 3-DD dose distribution for patients with breast cancer and malignant lymphoma. Radiother Oncol 1998b;49:233-243. .

Theuwss JC, Midler SH, SeppenwooWe Y et al. Effect of radiotherapy and chemotherapy on pulmonary functionn after treatment for breast cancer and lymphoma: A follow-up study. J CHn Oncol 1999:17:3091-3100. .

Theuwss JC, SeppenwooWe Y, Kwa SL et al. Changes in local pulmonary injury up to 48 months after irradiationn for lymphoma and breast cancer. Int J Radiat Oncol Biol Phys 2000;47:1201-1208.

V V

Vann de Steene J, Van den Heuvel F, Bel A et al. Electronic portal imaging with on-line correction of setup errorr in thoracic irradiation: clinical evaluation. Int J Radiat Oncol BkX Phys 1998;40:967-976.

Vann Dyk J, Keane TJ, Kan S, Rider WD, Fryer CJ. Radiation pneumonitis following large single dose irradiation:: a re- evaluation based on absolute dose to lung. Int J Radiat Oncol Biol Phys 1981 ;7 :461-467. Vann Dyk J, Man K, Keane TJ. Radiation-induced lung damage: dose-tirne-fractionatjon considerations. Radiotherr Oncol 1989;14:55-69.

Vann Dyk J, Newcomb CH, Man K, Keane TJ. Further comments on dose-time-fractionation considerations forr lung damage petter]. Radiomer Oncol 1990;18:183-184.

vann Herk M, Bel A, Gilhuijs KG, Vijlbrief RE. A comprehensive system for the analysis of portal images. Radiotherr Oncol 1993;29:221-229.

vann Herk M, Remeijer P, Rasch C, Lebesque JV. The probability of correct target dosage: dose-population histogramss for deriving treatment margins in radiotherapy. Int J Radiat Oncol Biol Phys 2000:47:1121-1135. .

Vansteenkrstee JF. Stroobants SG, De Leyn PR et al. Lymph node staging in non-smaH-cell lung cancer withh FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients. J Clin Oncol 1998;16:2142-2149. .

Vanuytsell U, Vansteenkiste JF, Stroobants SG et al. The impact of (18)F-ffuoro-2-deoxy-D-gIucose positronn emission tomography (FDG-PET) lymph node staging on the radiation treatment volumes in patiëntee with non-smalt cell lung cancer. Radiother Oncol 2000;55:317-324.

vonn ósr Maase H, Overgaard J, Vaetii M. Effect of cancer chemotherapeutic drugs on radiation-induced lungg damage in mice. Radiother Oncol 1986;5:245-257.

Vujaskovicc Z, Groen HJ. TGF-beta, radiation-induced pulmonary injury and lung cancer. Int J Radiat Biol 2000;76:511-516. .

W W

Webbb WR, Gatsoms C, Zerhouni EA et al. CT and MR imaging in staging non-small celt bronchogenic carcinoma:: report of the Radiologic Diagnostic Oncology Group. Radiology 1991;178:705-713.

Wederr W, Schmtd RA, Bruchhaus H et al. Detection of extrathoracic metastases by positron emission tomographyy in lung cancer. Ann Thorac Surg 1998;66:886-892.

Weibull,, W. A Statistical Distribution Function of Wide Applicability. Journal of Applied Mechanics 1951;18:293-297. .

Wongg JW, Sharpe MB, Jaffray DA et al. The use of active breathing control (ABC) to reduce margin for breathingg motion. Int J Radiat Oncol Biol Phys 1999;44:911-919.

(14)

References s

Y Y

Yann D, Wong J, VteW F et al. Adaptive modification of treatment planning to minimize the deleterious effectss of treatment setup errors. Int J Radiat Oncol Biol Phys 1997;38:197-206.

Yorkee ED. Modeling the effects of inhomogeneous dose distributions In normal tissues. Semin Radiat Oncoll 2001;11:197-209.

Yorkee ED, Kutcber GJ, Jackson A, Ling CC. ProbabHrty of radiation-induced complications in normal tissuess with parallel architecture under conditions of uniform whole or partial organ irradiation. Radiomer Oncoll 1993;26:226-237.

Youngg ME, Kometeen RO. Dose corrections for tow-density tissue ^homogeneities and air channels for 10-MVV x rays. Med Phys 1983;10:450-455.

Z Z

Zasadnyy KR, Kison PV, Quint LE, WaN RL. Untreated lung cancer: quantification of systematic distortion off tumor size and shape on non-attenuation-corrected 2-Ifiuofme-18]fluoro-2-deoxy-D-giucose PET scans. Radiologyy 1996;201:873-376.

(15)