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Congenitalhypothyroidism.nl
Kempers, M.J.E.
Publication date
2006
Link to publication
Citation for published version (APA):
Kempers, M. J. E. (2006). Congenitalhypothyroidism.nl.
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Colourr figures
Chapterr 3.1
Figure.. 1. Plasma free T4 and TSH concentrations in the children
100 20 30 40 50 60 70 80 90 100
20 0 30 0 400 50 60
Agee (days)
70 0 80 0 900 100
Plasmaa free 14 (upper panel) and TSH concentrations (lower panel) are shown for group A (red), group B (blue), andd group C (green). The results represent measurements before T4 supplementation was started. Open and closedd symbols are used to discriminate between different lines. The gray line in the upper panel represents the lowerr limit of the plasma free T4 normal range [i.e. 0.9 ng/dl (12 pmol/liter)]. To convert free T4 to Systeme Internationalee (SI) units, multiply by 12.87.
Figuree 2. TSH response after administration of TRH
30 0
90 0 timetime (minutes)
TRHTRH test results at neonatal age are shown for group A (red), group B (blue), and group C (green). In child Al (whoo also underwent a TRH test in the neonatal period) and child Bl (after T4 supplementation was interrupted forr a few months) a TRH test was performed at the age of 1 yr (black).
Colourr figures
Chapterr 4.2
AA B
'S'S '57 V
Agee (years) Age (years)
FT4(ng;dL.) )
Figuree 1. A and B, T4 dose, expressed in micrograms per kilogram per day (A), and plasma FT4 concentrations
(11 ng/dl = 12.87 pmol/liter) (B) in children, 0.5-20 yr of age, when TSH concentrations were within the refer-encee range [0.4-4.0 mU/liter for CH-T(a), CH-T(b), and AITD and 0.02 mU/liter for CH-C]. Concentrations are expressedd as mean surrounded by CI. Within all groups, data of children 16.5-20.0 yr of age are grouped together andd labeled 16.5. Red filled square, CH-T(a); green filled square, CH-T(b); blue open square, CH-C; pink triangle, AITD;; brown X, T1DM. C, Distribution curves of FT4of the different groups, when the simultaneously measured TSHH is within the reference range (same as for A and B). The table in the right upper corner represents FT4 mean
A A
2,0 0 1.8" " 1.6" " 1,4' ' gg 1.2 ££ i,o-HH 8 , 6 --, 4 " " .22 1 0 , 0 . .. .
"II
5
ïj
2,0 0 1,8 8 1,6" " 1,4 4 1,2' ' 1,0' ' ,8 8 ,6 6 ,4 4 ,2 2 nn n 1 1 TSHH (mU/L) TSH (mU/L)Figuree 2. A, FT4 concentrations (1 ng/dl = 12.87 pmol/liter) when TSH concentrations were between 0.4 and 1.3,
1.44 and 2.2, 2.3 and 3.1, and 3.2 and 4.0 mU/liter, respectively. Concentrations are expressed as mean surrounded byy CI. For children with CH-C, mean FT'4 concentration was 1.27 ng/dl (16.3 pmol/liter) when TSH was less than orr equal to 0.02 mU/liter. Red filled square, CH-T(a); green filled square, CH-T(b); pink triangle, AITD; brown X, T1DM.. B, FT4 concentrations in children with CH-T(a) (red filled square) aged more than 10 yr compared with thosee of children with Graves' disease (pink triangle) when TSH was within the reference range. Concentrations aree expressed as mean surrounded by CI.
Colourr figures
A A
B B
FT44 (ng'dL) 4 4 33 3 ^^ 2 ,05 5 .04 4 ,03 3 »» V i " * . " CH-T(a);; r=-0.473 p<0.001 CH-T(b):: i -0.319 p.11(101 A l i nn r=-0.417 p<0.001 T1DMM r= 0.045 p=0 549 FT44 (ng'dL) FT44 (ng/dL)Figuree 3. A, TSH concentrations (logarithmic scale) in children with CH-T, AITD, and T1DM when FT4 con-centrationss were 0.93-1.24 ng/dl (12.0-16.0 pmol/liter), 1.25-1.55 ng/dl (16.1-20.0 pmol/liter), 1.56-1.86 ng/dl (20.1-24.00 pmol/liter), and 1.87-2.18 ng/dl (24.1-28.0 pmol/liter). Concentrations are expressed as geometric meann surrounded by CI. B, Scatter plot of TSH concentrations (logarithmic scale) against FT4 concentrations and thee regression line (fitted by SPSS) for each group. The correlation coefficient and P value are indicated in the left lowerr corner. The lower and upper limit of the reference range for FT4 and TSH are indicated by the dashed lines. C,, TSH concentrations (logarithmic scale) in children with CH-C when FT4 concentrations were 0.93-1.24 ng/dl (12.0-16.00 pmol/liter), 1.25-1.55 ng/dl (16.1-20.0 pmol/liter), 1.56-1.86 ng/dl (20.1-24.0 pmol/liter), and 1.87-2.188 ng/dl (24.1-28.0 pmol/liter). Concentrations are expressed as geometric mean surrounded by CI. Red filled square,, CH-T(a); green filled square, CH-T(b); blue open square, CH-C; pink triangle, AITD; brown X, T1DM.
Figuree 4. Plasma T3 concentrations (1 nmol/liter =
655 ng/dl) when TSH concentrations were 0.10-0.39, 0.4-1.3,, 1.4-2.2, 2.3-3.1, 3.2-4.0, or 4.1-10.0 mU/liter. Concentrationss are expressed as mean surrounded by CI.. For children with CH-C, the mean T3 concentra-tionn was 162.5 ng/dl when TSH was less than or equal too 0.02 mU/liter. Red filled square, CH-T(a); green filledfilled square, CH-T(b); pink triangle, A1TD; brown X, 111 DM.
