• No results found

First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAFV600-mutant advanced melanoma patients: a propensity-matched survival analysis

N/A
N/A
Protected

Academic year: 2021

Share "First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAFV600-mutant advanced melanoma patients: a propensity-matched survival analysis"

Copied!
10
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)University of Groningen. First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAFV600-mutant advanced melanoma patients van Breeschoten, Jesper; Wouters, Michel W J M; Hilarius, Doranne L; Haanen, John B; Blank, Christian U; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; de Groot, Jan-Willem B; Hospers, Geke A P; Kapiteijn, Ellen Published in: British Journal of Cancer DOI: 10.1038/s41416-020-01229-1 IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.. Document Version Publisher's PDF, also known as Version of record. Publication date: 2021 Link to publication in University of Groningen/UMCG research database. Citation for published version (APA): van Breeschoten, J., Wouters, M. W. J. M., Hilarius, D. L., Haanen, J. B., Blank, C. U., Aarts, M. J. B., van den Berkmortel, F. W. P. J., de Groot, J-W. B., Hospers, G. A. P., Kapiteijn, E., Piersma, D., van Rijn, R. S., Suijkerbuijk, K. P. M., Blokx, W. A. M., Tije, B-J. J. T., Veldt, A. A. M. V. D., Vreugdenhil, A., BoersSonderen, M. J., & van den Eertwegh, A. J. M. (2021). First-line BRAF/MEK inhibitors versus anti-PD-1 monotherapy in BRAFV600-mutant advanced melanoma patients: a propensity-matched survival analysis. British Journal of Cancer, 124, 1222-1230. https://doi.org/10.1038/s41416-020-01229-1. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.. Download date: 23-06-2021.

(2) ÍÍÍÎÏÐÑÒÓÔÎÕÖ×ØÙÚÕ. 0123456. 789 9

(3) 8 .  !  "  #   $  %    & '     ( ) * +$$"',-./00+&''1%'21+'$+' ,'3',$,-+'2"1&%%'''-. 4567589:;<8556=>?@5;ABCBDE=>5FGH4HZDHG?I@586ABJBK?8:;;5LH]MEF:8EI6NB4?>;<HM::A;^5;OBP>8E6@E:;QH <F:;ROBSBD:I855A;4 H<HT:8@6UB A A C B V8:;=>5@@5GHWHA4JH9:;X5;<58RY?8@5FB4:A;N[GEFF5Y<HX5\8??@ABO\5R5THWHM?67586ABS_FF5;`:7E@5Ea; BKaI8:WE586Y: b??6cH9:;bEa;AZB`:8Ea;WHDHcIEaR58dIEaRAB]GEFF5R5THDH<F?Re B<58@[4:;4H@5;fECa5 BT6@8EXTHDH9:;X58g5FX@ AUB T8@g85IhX5;>EFBD:8i54H<?586[c?;X585; :;XTFj?;6I64HDH9:;X5;_58@k5h> lmnopqrstuvwxyz{|}{~xyz€‚zƒ„x‚ †w‡ˆ‰Š‹zxŒz€zy„ƒyŒƒyŽzx‘’„“„”„yƒz•yŒƒ’”zxyŒƒyƒyƒxy“ †w‡–—˜˜{‘yxy‚™x•ƒ‚ƒšx›œxyzšxŽ‚yƒzx•x•š‘„z™ƒxŽŒz•ŒyŒƒ’”y‘„ƒ„ž„y{šzxƒyƒyƒxy›ŸŒƒz“ yŒz„„y‘‚”Ž„y‘„ƒ’’ƒx„zy”„•ƒy•Œzxy•’ƒž„y{šzxƒxyz{|}{~xyŒƒ’”™„› †w‡ˆ‰Š‹zxŒz€zy„zx‚™x•ƒ‚ †w‡–—˜˜{‘yxyƒšx’yzƒxy„›  ¡¢£ru¤v¥ƒ„ƒšƒ•yƒ‚’yzƒxy„‚zx„ƒ‚€ƒyŽƒƒx¦˜~§x‚¦˜~¨ŽzyŒ‚™x•ƒ‚ƒšxx‚©xŽx †w‡–—˜˜{‘yyzx yƒyƒ‚ŽzyŒž„y{šzxƒ †w‡ˆ‰Š‹zxŒz€zy„xyz{|}{~xyz€‚zƒ„ƒz„yƒƒ‚zxyŒƒ}‘y•Œ‰ƒšxŸƒyƒxy†ƒz„y”›|yzƒxy„ Žƒƒy•Œƒ‚€„ƒ‚xyŒƒz’’ƒx„zy”„•ƒ„‘„zxyŒƒxƒƒ„yxƒzŒ€‘x‚yŒƒ’yzšy•ŒzxƒyŒ‚› q¡¤sª¢¤v ƒyŽƒƒx¦˜~§x‚¦˜~¨yyš“««˜x‚¦¬§‚™x•ƒ‚ƒšx’yzƒxy„ƒ•ƒz™ƒ‚ †w‡ˆ‰Š‹zxŒz€zy„x‚xyz{|}{ ~xyŒƒ’”„ž„y{šzxƒ„”„yƒz•yŒƒ’”›­xyŒƒy•Œƒ‚•Œy’yzƒxy„ƒ•ƒz™zxxyz{|}{~xyz€‚zƒ„„ž„y{šzxƒyƒyƒxy Œ‚ŒzŒƒƒ‚zxx‚¦{”ƒ™ƒšš„‘™z™š•’ƒ‚y’yzƒxy„yƒyƒ‚ŽzyŒž„y{šzxƒ †w‡ˆ‰Š‹zxŒz€zy„§¦›«xyŒ„®¯¬° ±­²«¨›«{³Š´™„›~¯›µxyŒ„®¯¬°±­²~—›¨¶¦§›«´x‚—¬›§°®¯–—¬˜°± ­²¬µ›~¶¨«›—´™„›§~›¨°®¯¬°±­²«§›¦¶¬~›˜´› nrtnªs¤·rt¤v¸‘‚y„‘ƒ„yyŒyzxyŒƒy•Œƒ‚ †w‡ ˜{‘yxy‚™x•ƒ‚ƒšx’yzƒxy„xyz{|}{~xyŒƒ’”z„ yŒƒ’ƒ“ƒƒ‚ž„y{šzxƒyƒyƒxyzx’yzƒxy„ŽzyŒƒšyz™ƒš”“™‘€šƒ’yzƒxyx‚y‘‘•Œ•yƒz„yz•„› ¹º»¼»½¾¿ÀÁºÂÃÄÀÅÆÃÂÇȺŒyy’„²ˆˆ‚z›ˆ~˜›~˜«µˆ„§~§~—{˜¦˜{˜~¦¦¯{~ lmnopqrstu ¸™ƒyŒƒš„y‚ƒ•‚ƒxƒŽ „”„yƒz•yƒyƒxy’yzx„Œ™ƒ ƒƒƒ‚ zx yŒƒ yƒyƒxy“ƒy„yyz• ƒšx›ŸŒƒ„ƒ ’’™ƒ‚yƒyƒxy„•x€ƒ‚z™z‚ƒ‚zxyyŽzx~¦‘’„² yƒyƒ‚yŒƒ’”•x„z„yzx“ †w‡x‚‰Š‹zxŒz€zy„ x‚ z‘ xyŒƒ’”xyz{|}{~x‚xyz{±ŸÉw{§x•šxšxyz€{ ‚zƒ„›«¶¬ ŸŒƒzz¦x—y‚‘•yzxŒ„zx•ƒ„ƒ‚yŒƒ™ƒšš„‘™z™š“ yŒƒ„ƒ’yzƒxy„› „ƒ‚x•šzxz•š•x„ƒx„‘„yƒyƒxy•Œz•ƒ ‚ƒ’ƒx‚„x„ƒ™ƒš’x„yz•x‚’ƒ‚z•yz™ƒ“•y„„‘•Œ„ †w‡{‘yyzx„yy‘„š•yyƒ‚ƒŒ”‚ƒx„ƒšƒ™ƒš„®É}Ê´’ƒ{ “x•ƒ„yy‘„x‚yŒƒy‘‘„yƒ›. w„ †w‡ˆ‰Š‹zxŒz€zy„Œ™ƒ’z‚x„ƒyx‚ŒzŒ™ƒšš ƒ„’x„ƒyƒ®¸††´yŒƒ”ƒ“yƒx•x„z‚ƒƒ‚yŒƒ’ƒ“ƒƒ‚’z” yƒyƒ xy“’yzƒxy„ŽzyŒƒËyƒx„z™ƒ®„”’yyz•´‚z„ƒ„ƒx‚ †w‡–—˜˜{‘yyzx›ÊŽƒ™ƒzx „‘•Œ ’yzƒxy„yŒ¨ƒ ƒ„’x„ƒ ‚‘yzxz„ƒšyz™ƒš”„Œy‚‘ƒy•Ì‘zƒ‚ƒ„z„yx•ƒ›w„yzƒy ƒ„’x„ƒ“z‘xyŒƒ’”z„ƒxƒš”šxƒx‚¸††šŽƒ •Œƒ•©’zxyzxŒz€zyzxz„‘„‘š”xyyŒƒ’ƒ“ƒƒ‚yƒyƒxy“ †w‡{‘yxy’yzƒxy„ŽzyŒ’’µx„yz•“•y„„‘•Œ„’ ’ƒ“x•ƒ„•ƒƒšƒ™yƒ‚É}ʛŸŒƒƒ“ƒyŒƒ’ƒ•ƒ’yzxyŒy •Œƒ•©’zxyzxŒz€zyzxšƒ‚„yƒ‚‘€šƒƒ„’x„ƒ„•‘š‚yšƒ„y ’yzšš”€ƒ ƒË’šzxƒ‚ €”yŒƒ “•yyŒy’yzƒxy„ŽzyŒ €ƒyyƒ. ~}‘y •Œ­x„yzy‘yƒ“±šzxz•šw‘‚zyzx†zßx„€‘ƒŽƒ~˜Éƒz‚ƒx¦«««wwŸŒƒ³ƒyŒƒšx‚„à¦}ƒ’yƒxy“‰ƒ‚z•š¸x•š”w„yƒ‚œ‰±–œœxz™ƒ„zy”‰ƒ‚z•š±ƒxyƒ ±x•ƒ±ƒxyƒw„yƒ‚}ƒ ƒšƒš§x~~~µw„yƒ‚ ~˜µ~Ê᝟Œƒ³ƒyŒƒšx‚„à«}ƒ’yƒxy“⑍z•š¸x•š”³ƒyŒƒšx‚„±¬x•ƒ­x„yzy‘yƒ|šƒ„xšx~¦~ w„yƒ‚~˜——±ãŸŒƒ³ƒyŒƒšx‚„à}ƒ’yƒxy“|Œ•”†‚ƒ‹‘z„ázƒ©ƒxŒ‘z„–x‚ƒššx~«— ƒ™ƒŽzß©~¯§¦ÉŠŸŒƒ³ƒyŒƒšx‚„à}ƒ’yƒxy“‰ƒ‚z•š¸x•š” yƒ‚~˜——±ãŸŒƒ³ƒyŒƒšx‚„à}ƒ’yƒxy“‰šƒ•‘š¸x•š”䭏‘xš”³ƒyŒƒšx‚„±x•ƒ x‚­‘xš”³ƒyŒƒšx‚„±x•ƒ­x„yzy‘yƒ|šƒ„xšx~¦~w„ ­x„yzy‘yƒ|šƒ„xšµx~¦~w„yƒ‚~˜——±ãŸŒƒ³ƒyŒƒšx‚„à¨}ƒ’yƒxy“‰ƒ‚z•š¸x•š”‰„yz•Œyœxz™ƒ„zy”‰ƒ‚z•š±ƒxyƒ|›}ƒ€”ƒšx¦¬‰„¯yz•Œy—¦¦¯Ê㝠ŸŒƒ³ƒyŒƒšx‚„à}ƒ’yƒxy“‰ƒ‚z•š¸x•š”á‘”‚ƒšx‚‰ƒ‚z•š~˜±ƒxyƒâzyy‚}›Ê›™x‚ƒÊ““’šƒzx~âzyy‚{僚ƒƒx—~—¦ 坟Œƒ³ƒyŒƒšx‚„à­„š¸x•š” x惒šƒzx~åxzxƒx ±ƒxyƒ­„š}©yƒ™xʃƒ„Žƒ¦áŽššƒµ˜¦¬w ŸŒƒ³ƒyŒƒšx‚„à }ƒ’yƒxy“‰ƒ‚z•š¸x•š”œxz™ƒ„zy”‰ƒ‚z•š±ƒxyƒåxzxƒxÊ ƒxyƒwš€zx‘„‚ƒƒ“¦Éƒz‚ƒx¦«««áwŸŒƒ³ƒyŒƒšx‚„à~¦}ƒ’yƒxy“­xyƒxš ¯¨~«å᝟Œƒ³ƒyŒƒšx‚„à~~}ƒ’yƒxy“‰ƒ‚z•š¸x•š”Éƒz‚ƒxœxz™ƒ„zy”‰ƒ‚z•š± ~ « ‰ƒ‚z•zxƒ‰ƒ‚z„•Œâ’ƒ•y‘ŸŽƒxyƒ‹xz~x§„’šƒzx~Šx„•Œƒ‚ƒ¨¬~¦‹áŸŒƒ³ƒyŒƒšx‚„à }ƒ’yƒxy“­xyƒxš‰ƒ‚z•zxƒ‰ƒ‚z•š±ƒxyƒÉƒƒ‘Ž‚ƒxÊƒxz}‘xxyŽƒ¦ É ƒƒ‘Ž‚ƒxµ¯«§w}ŸŒƒ³ƒyŒƒšx‚„à }ƒ’yƒxy“‰ƒ‚z•š¸x•š”œxz™ƒ„zy”‰ƒ‚z•š±ƒxyƒœyƒ•ŒyÊƒz‚ƒš€ƒšx~˜˜œyƒ•Œy«¬µ§±ãŸŒƒ³ƒyŒƒšx‚„à ~¬}ƒ’ yƒxy“|yŒš”}z™z„zx“É€yzƒ„|Œ•”x‚ zƒ‚z•šåƒxƒyz•„œxz™ƒ„zy”‰ƒ‚z•š±ƒxyƒœyƒ•Œy›Êƒz‚ƒš€ƒšx~˜˜œyƒ•Œy«¬µ§±ãŸŒƒ ³ƒyŒƒšx‚„à~—}ƒ’yƒxy“­xyƒxš‰ƒ‚z•zxƒw’Œzʁ„’zyš‰šƒx•Œy¦~ ƒ‚§µ~µ±‹Ÿ~Œµƒ³ƒyŒƒšx‚„à~¨}ƒ’yƒxy„“‰ƒ‚z•š¸x•š”x‚†‚zš”䳑•šƒ ‰ƒ‚z•zxƒŠ„‘„‰ƒ‚z•š±ƒxyƒç„{卙ƒx‚zß©Žš¦«˜†yyƒ‚ «˜~¬±ŠŸŒƒ³ƒyŒƒšx‚„à }ƒ’yƒxy“­xyƒxš‰ƒ‚z•zxƒ‰Ëz‰ƒ‚z•š±ƒxyƒ}ƒ†‘x§—˜˜ Šzx‚Œ™ƒx¬¬˜§} ŸŒƒ³ƒyŒƒšx‚„x‚~¯}ƒ’yƒxy“‰ƒ‚z•š¸x•š”†‚€‘‚œxz™ƒ„zy”‰ƒ‚z•š±ƒxyƒåƒƒy十yƒ’šƒzxá‘z‚~˜³zߏƒƒx—¬¦¬åwŸŒƒ³ƒyŒƒšx‚„. ±ƒ„’x‚ƒx•ƒ²wš“x„‘„蛉›™x‚ƒxŠƒyŽƒŒ®™x‚ƒxƒƒyŽƒŒé„yƒ‚‘•›xš´. 2%13ÛÜ&-Û0Û0%13Ý0Þ$%+#Û0Û022,13*0)2+#Û0Û0 êëìíîïðìñòóôõöï÷øíòíùúûïôüýíûüúí÷úíðñþÿ÷úíò0íôíÿòúì123435öúñòòíúðíø6ï7ûüúÿðüñ÷3435.

(4) UVWXYZ[\]^_`abc. T. )715674 ()*+,-747

(5) 76215 155 4672426 1 074 7 4(1 5826 4 6 . 01234256789 86215 1

(6) 74361 6 767426 1 0623 746 156 820 17524533 5656 67426 1 01 5657421 1

(7)  1 50245 5 5820 1 626 13 6 6 1 06 5 1 565 4 62

(8) 746 101 6 768 6724  626 026 467 

(9) 7 5 5. 55287 6 7667560 29 4 575  626 824924 743

(10) 74 78 6724

(11) 7 5  62. 820 17524

(12) 6 4

(13) 2631205

(14) 5 241 21 6 75 7986120 45765821  68743 5 6 675678  62   20

(15) 25 4

(16)  4 

(17) 745 8824659216 4   75617

(18) 672429824924 150120 45765821 756 8 48 29 1 8 77436 61 6 46

(19)  !5 24 51 824924 1558 5. 3 4 62156 3  "75 62  68 50 67 465

(20) 5 24 6 710120 45765821 81 6743 62 3120576 577 1 75617

(21) 672429824924 15 #467556  $%820 1 &'29()*+,-747

(22) 76215 4. 4672426 1 074 ()6 46  48   42. 0 67 465 4 $!%5 0120 45765821  6874362 6 174 6 2 1 517 746 ()*+,-747

(23) 762155 467242 6 1 031205 96 1 68743 ./01234 '6  5734 4 020 6724 "7524376 74 2

(24) 5 1 6724 56 5 6 9126 68 +  42 "1 6 46 37561 $+"% 020 6724

(25) 5  01250 867 1 375618 061743 0 67 4657641 5 86

(26)  56 3 ###8 4 #5  42 746 6 6 1 4 5'748 6 7 !8 0 67 46576 41 5 86

(27)  56 3 ###9 2156 3 #5   42 5 47424 296 :  42 8 461 5 

(28) 4 1 3756 1 746 +" 6. 1 01250 867 1 3756 1 912 7 342575467 6 67 465 1 922  161 2465 9218 43 574 75 5 56 650 67 465;8 1 86 175678521 61 6 468 1 86 1756785

(29)  4 74 0 4 4661 74 6.  4 3 1 6 7 5817068724296 +"5 60 5

(30) 4 0

(31) 75

(32) 728 5 6  0 67 46529< 15 4 2 1 7 3425

(33) 6 4!: 4 !=$ 6 5 686299 6  5<!%7 641 5 86

(34)  56 3 ###9 4 #5  42 76 >424()5?6 67242 5 4672426 1 0$0 

(35) 127@

(36) 21472

(37) %21 ()*+,-747

(38) 76215$

(39) 1 9 47

(40) A61  6747

(41) 21 1 9 47

(42) A 82

(43) 7 6747

(44) % 5 15674 556 786 1 0 1 5  86 921. 4 57592

(45) 74 67246 1 07 529 4821 9 47

(46) A

(47) 747 6747

(48) 4 7077

(49) A472

(50)  1 426 6  7

(51)  174367567 0 172 B74 296 1 0 5 4 56 56 1629 4  13 8 55 67 46576 21825   42  1 C8 912675 4 575 '6 675678  4 575 ( 5 74 0 67 46 4 75 5 8 1 86 175678529()5?6 46 0 67 465 1 4 5 5743 5817067 56 67567859 6 32178   17

(52)  5 1 820 1 5743 6 975 1 6 56& 1  517 $&'% 5 4 567 912 56 16556 7861 6 46 467 6912 48 5 768211 5024 7436257 DE 824 48 746 1 5 4  5 567 6 57436 - 0 4F+ 7 1  62 ""6" 5 4 56 67 4674 C661 6 4629. 4  138 5521 6912 48 5 &' 4 ""6"

(53) 6 4 5

(54) 31205 5820 1 5743231 4>6 5659218 6 32178   17

(55)  5 67 465 7 21256629220 1 17368 4521 6 6 67 29 561 3756 1 8246 86 #421 1621 8 824924 743

(56) 74 78 67240120 45765821  68743  55 5 15656 0 67 17

(57)  2375678 1 31 55724 4 575 55 62 567 6 0120 45765821 5 92 17 6 55 9216 67 17

(58)  23756781 31 55724 1. 3 6 7 342575$G=DH=D%

(59) 5 74 ,9&I0 1921 48 56 65 $F 4 H!%

(60) 5 74  86 6  123 4 5 $BJ%$421  !DFDK*B 4 LDK*B%56 3 6 7 342575$41 5 86

(61)  ###8 #5+ +

(62) 4 #5+8% 756 46 6 56 575$G8213 4576 5 4 H8213 4576 5742 %

(63) 1 74 6 56 5 5$424  5062 678. 4 5062 678% 4 7 1 6 56 5 5$ 5*42% 4 5 29 7422  6743 3 465$821678256 127 5 @ 6720174 4 746 19 124%92 17 6 5 1 825 4

(64) 5 2487478 01 86:78 D. 4 01 7251 5 187 46797436 5 0123425678175>9 86215  +246 9 12 57 6724 56  5 24561 6 6 675  62 295  8?674382 17 6 59210120 45765821  68743 21>5 1  67 17

(65)  92C0120216724  @ 1 52  55 62. 55 556 55287 67242901234256789 8621576&'123425678 9 86215 567 6  1 3 6 7 342575$G=DH=D%

(66) 5 74 ,9&I0 1921 48 56 65$F 4 H!%

(67) 5 74  86 6  123 4 5 $BJM421 !DFDK*B 4 LDK*B% 756 46  6 56 5 5$G8213 4576 5 4 H8213 4576 5742 %

(68) 1 74  6 56 5 5$424  5062 678 4 5062 678% 4 7 1  6 56 5 5$ 5*42%" 0120216724  @ 1 5 5506724 5 6 56 76 6 58  '82 49  1 57  5624 296 82 17 6 572 6 6 0120216724  @ 1 5 5506724 )21 6874301025 5N4 1 564 73

(69) 21 6874376. 8 70 15 629 55 9210120 45765821  68743"2. 55 556  7629 6874356 4 1 75  4 799 1 48 5921. 82 17 6 5 1 8 8 6 '6 4 1 75  4 799 1 48 529 G 1 55 62

(70) 4 3737

(71)  96 1 68743 47 17

(72)  92C0120216724  @ 1 52 76 12

(73) 56 17 48 567 621 62 882469216  68 4 61 296 5 0 . 55 62 567 6 6 1  67 8 43 74 @ 1 29517 =<"2 1 55 026 467 

(74) 7 5 5  6274820 6  68743 820 1 21 1 56562 5 824  68 5 0 5 657432067  68743 &067  687439215 68 0 7156274775 6  1 3 76740 71 799 1 48 74 0120 45765821 5 O 5

(75) 26  687436 847 57421 1622

(76) 5 1 6 74P 48 29 

(77)  48 01234256789 86215 81255

(78) 2631205746 4 1 56 4 73

(79) 21 68 312024&' 4 ""6"820 1 626 2067  68743 62  626  68 4 61 6 5 29. 231 4>6 56820 17436 517 8!1 577> 1 5674 60 # 11211 6 56 6 1 16787 2 561 67 231 4>6 565  1 5 < 62 820 1 6 517 81 5296  68 5 0 5 '6 675678 5296 1 5  5$ 157248D!M0 8> 3 5 8 167  15 517  4  6876% Q/4RS04  67 468 1 86 1756785 ( 6 4!: 4 8!!= 626 2988 4 !D:() 6 460 67 4657641 5 86

(80)  56 3 ###821#5  42. 1 8 7 ()*+,-747

(81) 7621521 4672426 1 01 50 8 67  515674 556 786 1 0$)73%& 1 0 67 465 1 8 7743()*+,-747

(82) 76215 5 15674 556 7861 6 46 . 73 1,9&I0 1921 48 56 65$H!N!8E 5<=E%   6 BJ  5$D8E5!!:E%#5+8 75 5 $<=?E5 ?=8E%

(83) 1 74 6 56 5 5$:<E 5<DE%7 1 6 56 5 5 $88E5!8E% 4  6 56 5 57421 213 4576 5$H8213 4 576 5ND:E 5:!DE%$"

(84)  %" 1  542 573478 46 799 1 48 74 3 4 3 4 1

(85) 6 40 67 4651 8 7743156 74 61 6 4676()*+,-747

(86) 76215 4 46773 4 5 + 7 4922067 8 8 6 76 1  15 - 0 4F+ 7 1  5!<824659216 626 020 6724'

(87) 5  466 1 07 5. 1 52474'00  46 4 5

(88) 5  466 1 07 529012 31 557 0 67 465 1 52474'00  46!& 1 01231 557 0 67 4656 61 8 7 15674 ()*+,-747

(89) 762151 8 7  55 5 824 4 671 74 6 1 0820 1 620 67 4651 8 7743 15674 467?8E5:!E 4 ?DE5:8:E 1 786215291 8 774315674 ()*+,-747

(90) 76215 "2 6 174 789 86215 1 55287 6 761 8 7743156 74 ()*+,-747

(91) 76215 67 17

(92)  23756781 31 55724 5 0 1921 $"

(93)  !%" 1 565526 6 4,9&I0 1921 48 56 6529H!$&N8DE9#NF8::%   6 BJ$&N!<: DE9#N<?F:8<% 4 5062 678

(94) 1 74 6 56 5 5$&N8<:.

(95) " !"#$%&')7= 241777 –7. BCDEFÿHIJKLMÿCNÿOEDPLHDQÿPH DRLÿSTBUÿVPEWHCQLV KLDXLLHÿYZ[\ÿEHVÿYZ[] ^_ÿ`ÿa\bYc qHFjÿOEDPLHDQÿXPDR mIDEHLCIQÿJLFEHCJE ^_ÿ`ÿa[r[c. BCDEFÿHIJKLMÿCNÿIoLEF JLFEHCJEÿ^_ÿ`ÿ[pZcÿCM JImCQEFÿJLFEHCJE ^_ÿ`ÿ[Y[c. iEDPLHDQÿXPDRÿEÿdbZZÿfUghe JIDEDPCHÿ^_ÿ`ÿ[r\pc. BCDEFÿHIJKLMÿCNÿOEDPLHDQ XPDRCIDÿEÿdbZZefUgh JIDEDPCHÿ^_ÿ`ÿ[bZYc. iEDPLHDQÿDMLEDLVÿXPDRÿEHDPe iSe[JCHCDRLMEOjÿCMÿfUghe TklÿPHRPKPDCMQÿEQÿNPMQDeFPHL QjQDLJPmÿDRLMEOjÿ^_ÿ`ÿ]ZYc. BCDEFÿHIJKLMÿHCDÿDMLEDLV XPDRÿEHDPeiSe[ÿJCHCDRLMEOj CMÿfUgheTklÿPHRPKPDCMQÿEQ NPMQDeFPHLÿQjQDLJPmÿDRLMEOj ^_ÿ`ÿn\]c. sCÿJPQQPHWÿoEFILQÿPHÿEHjÿCN DRLÿJEDmRPHWÿoEMPEKFLQ ^_ÿ`ÿrn\c. iEDPLHDQÿDMLEDLVÿXPDRÿEHDPe iSe[JCHCDRLMEOjÿEQÿNPMQDe FPHLÿDRLMEOjÿ^_ÿ`ÿYr\c. iEDPLHDQÿDMLEDLVÿXPDRÿfUghe TklÿPHRPKPDCMQÿEQÿNPMQDeFPHL DRLMEOjÿ^_ÿ`ÿaaZc. tuvwx yz{|}~€‚ƒ„ †‡ˆ‰Š‹ Œ‹ˆŽ‹‘’ ’„‰‹“ ”•. 012 34567189 7 6

(96)     !"#$%&'7()' 444*)'4+$ '   !"#$%&',- 5.760*012 345.7 9.7 /

(97) 7! 0 11*2*03*1242' 22 1  !"#$%&',56.7.1

(98) 7 7-8 42)'39-810 11 ,: 5 713*012 345 7 .967 3

(99) *%3-;42)06,: 5 673.*012345 7 8937.

(100) *<=:61..>#<,: 5373?*012345673/9/7?0

(101) 1242'2,: 5 7? *012 345 7//967/3

(102)  @7"2* 1242'2*203   @,A'3

(103) 7. 7412 ! 5 ')4412*3 . 4 )15 114   !"#$%&',1.2

(104)  114 7= ,1.2

(105) 7;)4  ,25867861

(106) *,/ 7 2  / 7 2 2

(107) *%3-;42 )06 , 7 2 7 7

(108) * <=:661.>#<,3.732 73.732

(109) *4+$ ,. 7/2 7. 7/2

(110) *03,/17?2 7/1762

(111) *'2 ,66782 766782

(112) *2,6 702  6 702

(113)  22)2) , 3712 7 3712

(114) 7A ) 2144127 4*6 /4 25 14   !"$%&0047=    2,8)4423

(115) 7-*2 4  !"#$%&'12. —.

(116) ˜. 4,30 ,212345)96,1,.,0832340, 0 880123456, —413221802204. RSTUVWX YZ[\]^_\`aZbZ`c\b^[c^`[d YZ[\]^_\xZb^Zj]\ pf\g\n^Z_zbZ_f\} ‡\_n\b rZ]\ q\gZ]\ s‰e‡mh\bŠkbgZ_`\[cZcl[ |ƒw ‹~ Œv ikcn\c\bg^_\nŽ_kbgZ] ~|ƒ||ŽŒ ||ŽŒ ycZf\z†ca\n^c^k_p‘‰‰} _b\[\`cZj]\’’’` ’“mrwZ ’“mrwj ’“mrw` YbZ^_g\cZ[cZ[\[ ik ”\[dZ[•ghckgZc^` ”\[d[•ghckgZc^` Œ^x\bg\cZ[cZ[\[ ik ”\[ ebfZ_[^c\[ |ƒ~ ‹{ ’ggl_kgknl]Zc^_fZf\_c[ ik ”\[ Yopq“„||mglcZc^k_ “„||s “„||t “„||oŽvŽs~. eb^f^_Z][Zgh]\ Yopqmrst zAQ{{|} ‚zw‚ƒ‚w} w† z{d‚} w~z€„dw}. p_c^muvmw zAQ~€} „~z~~ƒ †} w€z†dw} w|‚z€~d‚}. 9xZ]l\. ~€z††d|} †„z~{d|}. ~{~z‚wd{} ~~z d†}. ˆ|d||w. w€€z‚~d‚} wwz†dw}. w€€z‚~d‚} wwz†dw}. ˆ|d||w. w„€z€‚d†} w| z{~d†}  zw†d„}. w‚†z††d„} z~wd†} ~z|d }. ˆ|d||w. w| z„‚d†} €z~‚d|} ~zwd{}. w| z„‚d†} €z~‚d|} ~zwd{}. ˆ|d||w. wz€d} w{z{d‚} w{z{d‚} ~ ‚z †d„}. w€zd} ~‚zwwd€} €|zwd†} w†wz„†d{}. ˆ|d||w. w|z„d} w{z d€} w~z†d†} w~|z††d€}. w|z„d} w{z d€} w~z†d†} w~|z††d€}. ˆ|d||w. w‚~z d~} €~zw~d†} ‚„z~‚dw}. ~|†z wd} ~€z‚d€} ~{z‚dw}. ˆ|d||w ˆ|d||w. w~|z††d€} wz‚d†} ~|zw~d‚}. w~|z††d€} wz‚d†} ~|zw~d‚}. ˆ|d||w. ~w z„„dw} ww~z{{d‚}. ~||z† d†} €z~wd{}. w~wz† dw} {€z~wd‚}. w~wz† dw} {€z~wd‚}. ˆ|d||w. w{€z€|d„} w‚„z‚d€} ~€~z†{d{} z~„d†}. w€„z†d} w| z€~d} ~~€z d~} {|zwwd }. „zd} „‚z€€d} w{€z „d} ~wzw{d}. {z{d} †~z€„d} w{€z „d} ~wzw{d}. ˆ|d||w. ~†€z {d|} €€zw{d{} w~z{d„}. ~w~z {d} {zw{d } †z~d }. w{|z {d‚} w‚zw~d{} „z{d‚}. w{~z d~} w‚zw~d{} €z~d„}. |dw†† |d||. |d||w ˆ|d||w |d {{. i\Zb\[c_\^fajklbmgZc`a\n[Zgh]\ Yopqmrst p_c^muvmw zAQw} zAQw} „~zw‚ƒ‚w} „~z~ƒ †} wz~d{} wz~d{} †€z€†d†} †€z€†d†}. yrv |d|~† ˆ|d||w. ˆ|d||w ˆ|d||w |d|†{. ‰kghZb^[k_kŠjZ[\]^_\`aZbZ`c\b^[c^`[kŠhZc^\_c[b\`\^x^_fYopqŽrst^_a^j^ckb[kbZ_c^muvmwZ[Z–b[cm]^_\cb\Zcg\_c^_ca\kb^f^_Z][Zgh]\Z_nca\gZc`a\n [Zgh]\d. 01234561475883239

(117) 52383420409

(118) 5238342 040 47832802147224027 ! 22"#$$%04&2'( )*""++832 83&4,0242027-%.34,204042+## %,23204042--"$4727,88 740,&4&20# *8543270801240127 540,20/18322,2740, 0 880123456. ,,48082 '01281830.2832401,&%540,200324027/,0112345)96 ,1,.,0834730 ,2602,0324020/232832,82608 7,285432708540,200324027/,0140, 0 880123456 9:$$$%8& 3480206454;)2,2320,40243218/ , 4,&)27,4 82343,4/4$ 801*+. '<**;,540,20322,,&730 ,212345)96,1,.,083 -801*+ '<-# =9,540,20322,,&40, 0  ,&474730 ,20123456)27,4>>=>/4$801*+. '<";#,540,20322,,&730 ,212345)96,1,.,083 #*801*+ '<$;--,540,20322,,&40, 0  ,&474730 ,20123456?,@470/22 801 ?/23248 8/2383730 ,212345)96,1,.,0838543270840, 0  880123456%+* *+ '<-;#$47 - *+. '<-";+-* *+ '<#*;*-#47# *+. '<$;#"">4.2- ABCDBEF GBHIJKLMD 9DL9BGEHFN OCFPJHGI ' 012 24320 2,&1.83 4012781830AQ$%01282343,48730 ,212345)96,1,.,083/4,&,74068/238543270840, 0 0340,7278& 3489:$$$>1,401278183086 ,727540,200324027/,0140, 0 4712345)96,1,.,083 ,/1,101253852,068328.801540,20/4/,01,012532 204,523)27,4 ?8730 ,212345)96,1,.,083/48/23 8543270801240, 0 81830%*#801*+ '<";- -*+ ' =9)27,4>>=>8730 ,212345)96.

(119) /0674 01,-./01230120304567$67779140515426901  $91,67

(120) 254149 . RSTUVWX YZ[\]^_`]_a[b[cd]e\]f`bd`bee]cgh. i_`]_a[be qpg\b`fbr\s {dbqf_\bdc`]bes |}m~b_`e €}m~b_`e bg‚b` Y_[b ƒb„_[b †oj‡rb`c`„_gfbe\_\Ze twx €y ˆ‰Š ‹c\‚b\b`„]gb‚Œgc`„_[ ymtwmttŒˆ ŽmttŒˆ \_dbq}\b‚]\]cg{‘oos g`bebf\_a[bpppf pi‡Yx_ pi‡Yxa pi‡Yxf j`d_ge]\be twy € ’`_]g„b\_e\_ebe ‹c “be”_e~„r\c„_\]f “be”e~„r\c„_\]f ˆ]^b`„b\_e\_ebe ‹c “be p„„Zgc„c‚Z[_\]gd_dbg\e ‹c “be. jk thuv. lmnop qthvtwxhuys. ;^_[Zb thzml. kb xhmv. qthuzwyh}us. thxvl. kb xh v. qthlywxhlms. thx y. kb xhml. qthulwyhuls. thxy . kb yht th} kb thv} th thmu kb xhmy kb xhvt hl}. qxhuzwvh us thtty quh}}wxlmh ts |thttx qthx}wxhy}s qthxywthuus qthymwxh vs. thxvt thtyl thytx. qthluwyh ms. thtz . qth}zwyhzts qyhyyw}h ms. thy}l |thttx. RSTUVX YZ[\]^_`]_a[bocž‡`bd`bee]cg_g_[~e]ecjh ‹. {db |}m~b_`e myt €}m~b_`e zv bg‚b` ƒb„_[b y Y_[b yzx †oj‡rb`c`„_gfbe\_\Ze twx vuz €y lu ˆ‰Š ‹c`„_[ zx ymtwmttŒˆ xz ŽmttŒˆ zt ’`_]g„b\_e\_ebe ‹c ll “be”_e~„r\c„_\]f zz “be”e~„r\c„_\]f xxl ˆ]^b`„b\_e\_ebe ‹c vxu “be xzz ‹Z„ab`cc`d_ge]\be twy yul € ylm. Šk. lmnop. ;^_[Zb. x xhm . qxhxtwyhx s. thtxy. qth}mwxhx}s. thmum. x thlv x yh t. qxh}zw htxs |thttx. x xhyu h u x xh z xhu}. qthl}wxhlys tht}z qxhvvwyhv s |thttx. x xhxu. qthlwxhmms. thyvx. x xhym. qthlzwxhzys. thtlz. qthllwxhzms thtzm qyh vwvhuls |thttx. —˜™[_f\_\b‚b~‚`cdbg_eb”™š_Ÿ_`‚`_\]c”›œfcg•‚bgfb]g\b`^_[h. 46948042 674 01,-./012301203045671091*(5+ 674 01 ,-./01230120304567897 586

(121) 596459140515 4269&51427'%"#$7%'551427 qthmvwxhvms thzyl 5 %%I2#109166I65+ 674 01,-./01230120304567897 586

(122) 5964591405154269!&51427&"# $7451427"'%%#(0)'91'%5142*(897 qthuxwyhv}s thyyy 9 75 586+56,-./0123 0120304567

(123) 596 45 9140 15426945!   !5"44%#!   YZ[\]^_`]_a[b[cd]e\]f`bd`bee]cgc`bfb]^]gd•`e\‡[]gb’k{ƒ‡Y†–]g]a]\c` 5    5 "&5&#91 5%%   '4!"%5#$75   \`b_\„bg\h 4 !   "%4#4!   !!"4&&#91 &%   —˜™[_f\_\b‚b~‚`cdbg_eb”=šc‚‚e`_\]c”›œfcg•‚bgfb]g\b`^_[h 4'"!%#693 %#39 91"1067409475+425409 94

(124) 2

(125) 52564967258101/0 %62740948-80429 653774$96091

(126) 7409456897%5 5%"&#6277 012030456789715470 10

(127) 914  586

(128) 59645429140 4694148042 674 01914067

(129) 42299965+9423

(130) 5256451427!!"#$7%&"'!!# !01425409 94

(131) 279  (0)'91'%5142*(8979 75 586+56,-./01230120304567

(132) 5964591405154269'4"!# 45!!5"4'#91&%4"!5&#$74%5 JKLMNLLKOP !4!"5#&5   4'"!55#91 %!   620765643975169 856 57 940513979497

(133) 6037 5%'"#693  %#39 91"1067409475+42 19674 425$69 776$0$9 5+,-./Q&749149$91

(134)   9159 10 2357694

(135) 2

(136) 52564967258101/0 56274094 9401479+467701 674 014694148042,-./1230120304567 8-80429653774$96091

(137) 74094568975&"!# 569140515426914549 59401478694

(138) 2 62774694148042 674 019140 0 91767

(139) 42 677 401 0194

(140) 2906714294

(141) 2

(142) 52564940147 299965+942301420794

(143) 279 *$69 776$0$9 5+ 4694804291405154269979 674 01469414 4215194

(144) 2 9401476

(145) 0$01 ,-./01230120304567897 7258920 26'96776$0$9

(146) 5964594014746948042 70 10

(147) 914  586

(148) 596459140 5 691:;<# 674 01,-./1231091*(014291405154269 (7 14%#

(149) 52564897%'551427820 42091*(89745142701 9401476

(150) 0$01 ,-./0123012030456797 674 01469414 =;>?@AB@A>CD?EF1425409 94

(151) 2

(152) 52564GH4# 1421967410 2357694

(153) 2

(154) 5256494014746948042 5$69 776$0$9 89770 10

(155) 914  586+56,-./01230120304567 9140979 674 0146941429$20 26*(

(156) 59645

(157) 596 45 91405154269746940  5 691:;< 94014746948042,-./01230120304567979 674 01469414 #620794

(158) 2

(159) 5256401

(160) 79 94014746948042 626869 75940147825

(161) 57 154394

(162) 2*$69 8 674 01914094

(163) 28042425749 0:745+940147 94

(164) 294014780426 940$  5565 15707+9

(165) 4567825 kb thul kb xhvx. ¡.

(166) 930316789

(167) 3330410#3103!!! Ó46011211!. Ô. OGEPMQIGRSÿMESHMTSRM. :;;<. VWXOQYZ[ÿGR\GLGMKEP. XRMGQ]^Q:ÿTKRKM\SEHJN. CDEFGFHIÿJEKLHLGIGMN. >;<. U><. OGEPMQIGRSÿMESHMTSRM. VWXO_YZ[ÿGR\GLGMKEP. XRMGQ]^Q:. =><. ;. e. `DTLSEÿHMÿEGPa VWXOQYZ[ÿGR\GLGMKEP bb; Ucd XRMGQ]^Q:ÿTKRKM\SEHJN U>c. ;. >;<. U><. ?ÿAÿ;B;;;:. Ub; e. :U gGTSÿhTKRM\Pi. :d. :>c. :;U. >d. U;b. :eb. ::e. :d. Uc. :U gGTSÿhTKRM\Pi. ;< ;. Uc OGEPMQIGRSÿMESHMTSRM. CDEFGFHIÿJEKLHLGIGMN. =><. ;<. OGEPMQIGRSÿMESHMTSRM. :;;<. c. d. :U gGTS. :e. U;. Uc. :b=. fb. ec. c>. U. :d=. :ec. :cc. :b;. ::;. d. c. d. :U gGTS. :e. U;. Uc. `DTLSEÿHMÿEGPa VWXO_YZ[ÿGR\GLGMKEP bb; U>b XRMGQ]^Q:. U>c ;. jklmn opqrpstuvwvxvyzw{pzv|}~ps€‚|}ƒxyz„rwsv †‡ˆ‰uŠows‹wŒwz|xyyŽpszw„„‘{|s|z‹vxpq’Ž“”•–”—˜™š›šœšž›Ÿ”žš ¡¢£ ¤–š¡ž¥”—¦§§¨§¤œ›©ªž¥ ¡«œž¬–›—š­®¯°±™²“›—ª›³›ž œ´µ”—ž›¬¶·¬¸Ÿ — žªšœ”•¹µº —«¦š—»š›—žšœ´”–›¦›•–”¹š¦³¹žªšª”¦ ¼ ¡³ žª »½œ´šµ ¾¿ÀÁÂÃm §§¨§”—¦¢£šž›Ÿ”žš ¡¦›¡¡šœš—žŸšžª ¦µ. ­®¯°±™²“ ¯—ž›¬¶·¬¸Ÿ — žªšœ”•¹ ›—ª›³›ž œ ¢´šœ”–– ™š¦›”—§§¨§ ™š¦›”—¢£ ğ —žª ¸ÆŸ —žª Æǟ —žª ™š¦›”—§§¨§ ¤Ÿ —žª¥ ¤Ÿ —žª¥ ¤Å¥ ¤Å¥ ¤Å¥ ¤Ÿ —žª¥ “”•–”—˜™š›šœ ̵ͤĵƘε̥ ¸¸µÍ Ì浃 ÇÌµÌ Æ쵀 ¸ÎµÉ šž›Ÿ”žš ¤ÉµÉ˜¸ÏµÌ¥ ¤Ì¸µÇ˜Î͵̥¤ÇƵĘÊϵǥ ¤¸ÉµÍ˜Æɵϥ ¤¸¸µÍ˜Æǵǥ ¨š”œšž ¸ÍµÆ¤ÌµÌ˜¸ÊµÍ¥¸ÉµÎ ÎÇµÏ ÄÊµÏ Ç¸µÌ ¸ÇµÄ —š›©ª³ ½œ ¤¸ÄµÌ˜Æǵϥ ¤Ìε̘É͵ϥ¤ÊεƘÌϵϥ ¤ÏǵƘʸµÍ¥ ¤¸Íµ¸˜Æ̵̥ Ÿ”ž»ª›—© ¢•ž›Ÿ”–Ÿ”ž»ª›—© ̵Ĥĵ¸˜ÉµÉ¥ ¸ÊµÄ ÎÏµÌ Ê̵¸ ÏÇµÇ ¸ÎµÉ ¤¸ÆµÊ˜¸Éµ¸¥ ¤ÌɵϘÎεǥ¤Ê¸µÏ˜Äϵĥ ¤Æε̘ǸµÏ¥ ¤¸¸µÍ˜Æǵǥ. ™š¦›”— ¤Ÿ —žª¥ ÇÆµÏ ¤Ïǵά¨²¥ ÇÆµÏ ¤Ï̵Ϭ¨²¥ ÇÆµÏ ¤Ïǵά¨²¥. ğ —žª ¸ÆŸ —žª Æǟ —žª È® ¤ÉÊź˥ ¤Å¥ ¤Å¥ ¤Å¥ ɸµÏ θµÌ ÊÌµÉ ÍµÏÄ ¤Î̵ɘÉǵΥ¤Ì̵͘Îĵĥ ¤Ê¸µÎ˜ÄǵΥ ¤ÍµÆΘ͵ÇÊ¥ ÄÊµÇ ÍµÊÍ ÉÆµÉ ÎÏµÍ ¤ÎɵɘÉ̵ͥ¤Ì̵ϘÎɵƥ ¤Êε¸˜Ìϵĥ ¤ÍµÏĘ͵ÌÍ¥ ɸµÏ θµÌ ÄÇµÍ ÍµÇÏ ¤Î̵ɘÉǵΥ¤Ì̵͘Îĵĥ ¤ÊεƘÌ͵ǥ ¤ÍµÏǘ͵ÊÄ¥. §§¨§”—¦¢£šž›Ÿ”žšª ¼—”½œ´›´”–œ”žš”žÄиƔ—¦Æǟ —žª”—¦Ÿš¦›”— ´šœ”––½œ´›´”–žœ”ž›«š¦¡ œ«œž¬–›—šžªšœ”•¹¤­®¯°±™²“›—ª›³›ž œ´µ”—ž›¬ ¶·¬¸Ÿ — žªšœ”•¹¥µ Ñҗ —šž›Ÿ”³–šµ. 012134156789

(168) 33303313013410 032001213415310 031 13210!"1#21531231531 3003220012134156789

(169) 3330 0311051313503220 012134153 03113210!$13 2315%1215310121343 0313 %01#3310&'06789

(170) 333032(10 31101 215%322#5%3#0%150135# 2#53!)*1+#1%122011122 6789

(171) 33300331#2150#!$ 6789#313410003%6789

(172) 333031101100152321 031 011 301101#3+#32(3##0011!, "3#5#13121520%233 313013414#01315##020210 332%31031 0310113. 2321!-1410%101#11512 015305315 2332031303151+#12110! *#001%14102332030134133130 310113#105011510!"1 *&.6&/#514#1151+#12141#0135 23133%15333#,,534#4!333#  5 34# 01*"2,34)5256! "17

(173) 8 1+ #5 01*"2,,,78)614#11+#12150135013 3#30013%15333#534#0 333#534##300131550 1350133!"1'

(174) *& 6$"01*"2,45778614#11 1+#12112013#3313315333# #34#01311+#121012013# 331330)11(15333##34#  #300131512013#33133!,5%,7 "11#5310119121512115115,2, 5,2,,!.

(175) 85%167868<53413%565541%2' 1%3641 «417665&3%616%4 =>?@ABC>DEÿA?EGAHEDA. TXXY. TXXY. \]?^>^GCÿU?QPGP>C>AV. \]?^>^GCÿU?QPGP>C>AV. [XY. _[Y. ¬. KDA>BRSBT. [XY. _[Y. `. X. a. d]HPE?ÿGAÿ?>@e IJK=BLMNÿ>DO>P>AQ?@ T[[ T`_ TTg KDA>BRSBTÿHQDQAOE?GUV. T[[ T`b `. X. TfZ a. T_ c>HE. Tb. ga. a[. b_. `X. T_[. TXZ. g`. Z[. T_ c>HE. Tb. _X. _`. _X. XY. _` =>?@ABC>DEÿA?EGAHEDA. =>?@ABC>DEÿA?EGAHEDA. IJK=WLMNÿ>DO>P>AQ?@. Z[Y. Z[Y. XY. =>?@ABC>DEÿA?EGAHEDA. KDA>BRSBTÿHQDQAOE?GUV. IJK=BLMNÿ>DO>P>AQ?@. X. a. T_ c>HE. Tb. _X. _`. af. bf. `Z. f[. _. TTf. TXX. ab. Za. bg. [. `. a. T_ c>HE. Tb. _X. _`. `. d]HPE?ÿGAÿ?>@e IJK=WLMNÿ>DO>P>AQ?@ T[[ T_` KDA>BRSBT. T[[. X. hijkl mnopnqrstutvtwxuynxtz{nq|}}~}€xtqtnvtwxqtu‚ƒ„v ynx†t|wnyopt‡ˆ‰Š‹‰ŒŽ‘’“”‰“’•–—˜™‹–“š‰Œ›œœœ™‘žŸ“š –•‘“ŸŒ‰‘’“ŒžŸ •¡‘¢”‰“£Ÿ›£•Ÿ•‘“¤¥•Œ¦›Œ£Œ“‘§‰‹’›’Š‹‰¨› ¨“Ÿ’Ÿ‰›•©•– •“Ÿ£¡‘§’¤ =>?@ABC>DEÿA?EGAHEDA. TXXY. TXXY. \]?^>^GCÿU?QPGP>C>AV. \]?^>^GCÿU?QPGP>C>AV. [XY. _[Y. KDA>BRSBT. [XY. _[Y. X. `. a. d]HPE?ÿGAÿ?>@e IJK=BLMNÿ>DO>P>AQ?@ _[` _ff TZg KDA>BRSBTÿHQDQAOE?GUV _[`. X. _fZ. __f. `. a. T_ c>HE. Tb. T`_. TTa. a[. [b. _Xf. TZ`. T`g. TTb. T_ c>HE. Tb. _X. _`. _X. XY. _` =>?@ABC>DEÿA?EGAHEDA. =>?@ABC>DEÿA?EGAHEDA. IJK=WLMNÿ>DO>P>AQ?@. Z[Y. Z[Y. XY. =>?@ABC>DEÿA?EGAHEDA. KDA>BRSBTÿHQDQAOE?GUV. IJK=BLMNÿ>DO>P>AQ?@. X. a. T_ c>HE. Tb. _X. _`. T_b. aZ. b_. ``. _. TaZ. Tb`. T``. TfX. TTX. a. `. a. T_ c>HE. Tb. _X. _`. `. d]HPE?ÿGAÿ?>@e IJK=WLMNÿ>DO>P>AQ?@ _[` _X[ KDA>BRSBT. _[` X. hijkª mnopnqrstutvtwxuynxt€xtoxuynpynx†t|wnyopt‡ˆ‰Š‹‰ŒŽ‘’“”‰“’•–—˜™‹–“š‰Œ›œœœ™‘žŸ“š–•‘“Ÿ•Š“”‰‹”‰“£Ÿ› £•Ÿ•‘“¤¥•Œ¦›Œ£Œ“‘§‰‹’›’Š‹‰¨› ¨“Ÿ’Ÿ‰›•©•– •“Ÿ£¡‘§’¤. 0123456789 5

(176) 645445 64 41 !"14

(177) !#941$%3665%5%355%  %3%3641 56 &1&4%45%341%2' $41 5

(178) 6(1 4 3$36 6454)* 

(179) "# 90+,-*../ 355 640466&4566 616&% 64544%61%5. %64%6 1 &1&44&%&6 % 6 5456 6 % 14464%61%41 %&344&%65%&5266

(180) 1%36 9239456 3,..5% 

(181) 17868%64%61%5661& 6 41 %36439:; 3,,.1& 6 17#7868%41%4%61%5. 36564%61%54&0%64%61%%15%37868<53413%5

(182).

(183) n. *279

(184)  2 8(%)*+,-2 122

(185) 79879 95

(186) 24 

(187) 187562  S5 (788931

(188) 8 8

(189) 5   5

(190) 55  75

(191) 2  

(192) 1845 9372

(193) >(87748 5

(194) 5 01231 456789

(195) 2 8087

(196) 785

(197) 48

(198) 

(199) 2 9552 5 85

(200) 87 2

(201) 8729728

(202) 2

(203) 5

(204) 29

(205) 63 38

(206) 2 18 802

(207) 1

(208) 185 5 69295 2

(209) 8778

(210) 5

(211) 2 

(212) 18 778992  5

(213) 2

(214) 785

(215) 48

(216) 

(217) 18

(218) 18715 2  7 535@

(219) 5  1845 9372

(220) 5 87748372

(221) 235 78292 5 1 5 575  45

(222) 3185

(223) 2317

(224) 5

(225) 28

(226) 9155598 2 8 

(227) 18457 5 

(228) 983

(229) 72

(230) S<877485

(231) 553@ 292

(232) 2 9

(233) 63 38

(234) 2 18 802

(235) 1

(236) 18 87745 389

(237) 5

(238) 9!"#18985

(239) 28

(240) 915888 8$3 874 5 5 69295 2 

(241) 185

(242) 575

(243) 8

(244) 1845 9372

(245) 5 87748372

(246) 235

(247) 18782 9 648

(248) 2 8%#&95 595789

(249) 080 8$83

(250) 78292 5 1

(251) 857 578

(252) 57

(253) 25  

(254) 1845 9372

(255) (877485

(256) 553@ 292

(257) 2 9

(258) 6

(259) 15

(260)

(261) 183 2 235 

(262) 3489

(263) 1299

(264) 60 8079834578 3 38

(265) 2 18 802

(266) 1

(267) 185 69295 2

(268) 8778

(269) 5

(270) 2 

(271) 185

(272) 575

(273) 8

(274) 18

(275) %#&94578

(276) 1598'%#&9(%)*+,-2 122

(277) 79 8 45 9372

(278) 5 87748372

(279) 2355 7 292 5 1 5 575 

(280) 1845 9372

(281)  68579 725 059"75758" "25 

(282) 7548

(283) 2 25 ./ ,)877485

(284) 553@ 292

(285) 2 9

(286) 863 18 802

(287) 1

(288) 185 5 69295  0 784 758 25 3248

(289) 2 2 4578

(290) 

(291) 186857 2

(292) 8778

(293) 5

(294) 2 

(295) 185

(296) 575

(297) 8

(298) 1845 9 33782

(299)

(300) 25  87748372

(301) 235 78292 5  9 725 

(302) 1299

(303) 6081 5 08768579 725 0/'23/ 11 8 5 8502 75 

(304) 1845 9372

(305) *(877485

(306) 553@ 292

(307) 2 9

(308) 63 38

(309) 2 

(310) 1

(311) 185 5 69295 2

(312) 8778

(313) 5

(314) 2 

(315) 185

(316) 575

(317) 8

(318) 1845 9372

(319)  45/6"7''82878 3892 9 725 3 878 5

(320) 8

(321) 512187 877483 1 5 575 

(322) 1845 9372

(323) S877485

(324) 5 5820"9//82 3 92  !"284785

(325) 28

(326) 902

(327) 149 53@ 292

(328) 2 97

(329) 2

(330) 23563 78 32982 5 18 802

(331) 1

(332) 185 5 69295 2

(333) 8778

(334) 5

(335) 2 

(336) 185

(337) 5 ,3298598290"70'85 2 3 92 5

(338) 28

(339) 902

(340) 1752 75

(341) 8

(342) 1845 9372

(343) 5

(344) 2  87748372

(345) 235 78292 5 1 5 575 

(346) 18 48

(347) 59

(348) 59892""082  745

(349) 318954 8 45. 9 3 7 2 

(350)   <  8 7   7 48  5

(351) 553@ 292

(352) 2 9

(353) 63 38

(354) 2 18 802

(355) 1

(356) 18 ) 

(357) 187785 07 9

(358) 62 89

(359) 25

(360) 2 

(361) 18

(362) 3489179

(363)  2 8 5 5 69295 2

(364) 8778

(365) 5

(366) 2 

(367) 18 5

(368) 575

(369) 8

(370) 1845 9372

(371) 5 87748372

(372) 235 244 " 

(373) 187565 

(374) 578

(375) 8

(376) 18756059877486: ;8 78292 5 1 5 575 

(377) 1845. 9372

(378) -877485

(379) 553@ 292

(380) 2 9

(381) 6 8

(382) 5  98

(383)  73 778

(384) 9

(385) 6

(386) 1861 5 53;9 725 3 38

(387) 2 18 802

(388) 1

(389) 185 5 692 95

(390) 8778

(391) 5

(392) 2 

(393) 185

(394) 575

(395) 8

(396) 18 8 81

(397) 75

(398) 28

(399) 9783822 179

(400)  2 8244 

(401) 18756892

(402) 85 45 9372

(403) 5 87748372

(404) 235 7829 22 5 1 5 575 

(405) 1845 9372

(406)  877485

(407) 553@ 292

(408) 2 9

(409) 63 38

(410) 2 18 802

(411) 1

(412) 185 5 69295  5 75 8245 5 387 9

(413) 2353

(414) 79#18982878 3893   

(415) 185

(416) 575

(417) 8

(418) 1845 9372

(419) 5 87748372

(420) 235 78292 5  88$ 52 86

(421) 188738

(422) 58,35

(423) 28

(424) 92.82  79

(425) 6 21

(426) 58 7578

(427) 57

(428) 25  

(429) 1845 9372

(430) %%877485

(431) 553@ 292

(432) 2 9

(433) 63 38

(434) 2  9/35 /02

(435) 189

(436) 66: ;88

(437) 5 )2783

(438) 345729 18 802

(439) 1

(440) 185

(441) 8778

(442) 5

(443) 2 

(444) 185

(445) 575

(446) 8

(447) 1845 9372

(448) 5  8

(449) 088 

(450) 19

(451) 28929157 8

(452) 2878 3892 5

(453) 28

(454) 5  87748372

(455) 235 785 62992295 5 2. 1 5 575 

(456) 1845 9372

(457) -?877485

(458) 5

(459) 4 7315753

(460) 8729

(461) 2399

(462) 6892 5 875123 35

(463) 2  2

(464) 2 9

(465) 63 38

(466) 2 18 802

(467) 1

(468) 185 5 69295 2

(469) 8778

(470) 5

(471) 2 

(472) 185

(473) 5 #1878578 242

(474) 5

(475) 2 9

(476) 

(477) 1299

(478) 6*279

(479) 

(480) 1299

(481) 62 

(482) 5375@

(483) 829

(484). 9372

(485) 5 87748372

(486) 235 78292 5 1 5 575 

(487) 18 2 3 8 5

(488) 28

(489) 901 783828 22 24 45 4 

(490) 18756 7 45 93721

(491) 845 )#877485

(492) 553@ 292

(493) 2 9

(494) 63 38

(495) 2 18 802

(496) 1

(497) 18 22 24 45342 802

(498) 1 2 4542 24 454 

(499) 18756 5 5 69295 2

(500) 8778

(501) 5

(502) 2 

(503) 185

(504) 575

(505) 8

(506) 1845 9372

(507) 5 87748372

(508) 235 29   8728 5917"96

(509)  2 8

(510) 785

(511) 48

(512) 92 385

(513) 2159 78292 5 1 5 575 

(514) 1845 9372

(515) )9877485

(516) 553@ 292

(517) 2 9

(518) 6  38

(519) 2 18 802

(520) 1

(521) 185 5 69295 2

(522) 8778

(523) 5

(524) 2 

(525) 185

(526) 575

(527) 8

(528) 18 78 9 8727813536 <0887342 5

(529) 2

(530) 18756 345 87748372

(531) 235 78292 5 1 5 575 

(532) 1845 9372

(533)  22 24 45 5  2 45 15978

(534)  8 883

(535) 2"38 2 9  9837727

(536) 5 5

(537) 553@ 292

(538) 2 9

(539) 63 38

(540) 2 18 802

(541) 1

(542) 185 5 69295  48

(543) 59

(544) 5

(545) 2348 5 455

(546) 28

(547) 92

(548) 18<-,)#=0

(549) 725  >8 2

(550) 8778

(551) 5

(552) 248 

(553) 185

(554) 575

(555) 8

(556) 1845 9372

(557) 5 87748372

(558) 235 78292 5  2 

(559) 1588  15

(560) 28

(561) 901783828342 5

(562) 2

(563) 18756 1 5 575  

(564) 1845 9372

(565) ,(877485

(566) 553@ 292

(567) 2 9

(568) 63 38

(569) 2  22 24 455  2 45

(570) 45;8578 25 85 5 6929

(571) 129 18 802

(572) 1

(573) 185

(574) 8778

(575) 5

(576) 2 

(577) 185

(578) 575

(579) 8

(580) 1845 9372

(581) 5  7 ?83 

(582) 189875

(583) 2 5 5

(584) 78

(585) 18,#%456158 87748372

(586) 235 785 62992295 5 2. 1 

(587) 1845 9372

(588) )059789 92 8 2

(589) 7 38 259<088792 38

(590) 18 9

(591) 57

(592) 

(593) 1297829

(594) 76 7

(595) 189

(596) 63 38

(597) 2 5 89 25 55 57 695295 2

Referenties

GERELATEERDE DOCUMENTEN

To get a deeper insight into the specific aspects of a phishing email that makes these messages detectable, a data set containing a large number of phishing emails is analysed using

Active devices such as Blade Pitch Higher Harmonic Control and Active Control of Structural Response or Force Transfer v..rere consequently studied and demonstrated

This chapter provides a contemporary overview of patient and procedural characteristics of tricuspid valve repair and replacement and early and late out- comes in different

The aim of this article is to assess the Myers Briggs Type Indicator (MBTI®) from a Reformed perspective of a Trinitarian biblical hermeneutic of hope.. It examines and

er vrijwel geen verschil tussen de groepen stieren die pluimveemest- houdend mengvoer ontvingen en de controlegroepen is.. De eindconclusie moet dan ook in deze voederproef zijn,

Wanneer een schaaltje in een looplijn van de dieren wordt geplaatst, bijvoorbeeld tussen het voer en water, kunnen er een groot aantal dieren worden gewogen.. Ver- der kan een

N fijn (vrucht), kantig, veel gewas, goudspikkels, korte plant (2x), magnesiumgebrek (3x), kniktrossen, geaderde vruchten. 0 magnesiumgebrek, geen mooie bladstand, kniktrossen,

Drawing insights from a review of the (partial) delivery of the former NSW Government ’s Parramatta Rail Link project, it evaluates social impact management strategies applied