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Oesophagogastric cancer: exploring the way to an individual approach
Stiekema, J.
Publication date
2015
Document Version
Final published version
Link to publication
Citation for published version (APA):
Stiekema, J. (2015). Oesophagogastric cancer: exploring the way to an individual approach.
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11,5
mm 10 mm
UITNODIGING
Voor het bijwonen van de openbare verdediging van mijn proefschrift.
DONDERDAG 22 JANUARI om 14.00 uur Agnietenkapel Oudezijds Voorburgwal 231
te Amsterdam
Aansluitend bent u uitgenodigd voor een receptie ter plaatse.
PARANIMFEN Thomas Mosk Berend Schols Jurriën Stiekema Swammerdamstraat 19 IV 1091 RP Amsterdam j.stiekema@nki.nl
OESOPHAGOGASTRIC
CANCER
EXPLORING THE WAY
TO AN INDIVIDUAL
The work described in this thesis was performed at the Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, the Netherlands.
The research was funded by the Cornelis Vrolijk Development Fund
Unrestricted financial support for publication of this thesis was provided by: The Netherlands Cancer Institute – Antoni van Leeuwenhoek, Academic Medical Centre, the OOA Oncology Graduate School Amsterdam and the Dutch Society for Gastroenterology (NVGE).
Cover design & layout: sophie ontwerpt// Printed by: Gildeprint
ISBN: 978-94-6108-885-7
Online: http://www.dare.uva.nl/disseraties
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval without prior permission of the holder of the copyright.
Oesophagogastric cancer
Exploring the way to
an individual approach
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus prof. dr. D.C. van den Boom
ten overstaan van een door het college voor promoties ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel op donderdag 22 januari 2015, te 14:00 uur
door
Jurriën Stiekema
PROMOTIECOMMISSIE
Promotor: prof. dr. E.J.T. Rutgers Copromotor: dr. J.W. van Sandick
Overige leden: prof. dr. H.W.M. van Laarhoven prof. dr. J.J.B. van Lanschot prof. dr. J.P. Medema prof. dr. B.L.A.M. Weusten
prof. dr. M. Verheij dr. G.A.P. Nieuwenhuijzen
6
CONTENTS
CONTENTS
Chapter 1 General introduction & outline of the thesis 8
PART I. Surgical Treatment & Patient Selection
Chapter 2 Quality of care indicators for the surgical treatment 18 of gastric cancer: a systematic review
Chapter 3 Surgical treatment results of intestinal and diffuse type 46 gastric cancer: implications for a differentiated
therapeutic approach?
Chapter 4 Detection of interval metastases and assessment of 62 response using 18F-fluorodeoxyglucose PET/CT after
neoadjuvant chemoradiotherapy for oesophageal cancer
Chapter 5 Surgical treatment of gastrointestinal stromal tumours 78 located in the stomach in the imatinib era
PART II. Multimodality Treatment
Chapter 6 Recent trends in multidisciplinary treatment of 96 oesophageal, oesophagogastric junction and gastric
cancer in the Netherlands
Chapter 7 The prognostic significance of an R1 resection in 114 gastric cancer patients treated with adjuvant
chemoradiotherapy
Chapter 8 Does chemoradiotherapy improve the prognosis of 130 gastric cancer after an R1 resection? Results from a
Dutch cohort study
PART III. Genetic Profiling
Chapter 9 Prognostication and prediction using gene expression 146 profiling in oesophageal cancer
Chapter 10 Biobanking of fresh‐frozen endoscopic biopsy 162 specimens from oesophageal adenocarcinoma
7 CONTENTS
Chapter 11 Genome‐wide copy number analysis for patient 174 stratification and therapeutic target identification
in oesophageal adenocarcinoma patients
Chapter 12 Discussion & future perspectives 190 Summary 200
Samenvatting 206
PhD Portfolio 212
Dankwoord 218
