Nederlandse Samenvatting
Chapter 8 eclamptische placentas Placenta perfusie bevestigde dat de afgifte van AGT in de placenta
in de tijd afneemt, hetgeen wijst op een ‘washout’ van uit het bloed opgenomen AGT. In tegenstelling hiermee, bleef de afgifte van (pro)renine uit de placenta juist stabiel tijdens een 3 uur durende perfusie, en steeg tot hoeveelheden die >5-maal hoger lagen dan de spiegels die in placentaweefsel gemeten worden, wat op voortdurende synthese wijst. Dit was overwegend prorenine. Concluderend suggereren onze bevindingen dat de RAS activiteit in de placenta afhankelijk is van maternaal AGT dat opgenomen wordt vanuit het bloed. Er is geen bewijs voor verhoogde RAS-activiteit in de placenta bij pre-eclampsie.
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Chapter 3
Ph.D Portfolio
Name: Department: Research School: Promotor: Co-promotors: Yuan SunInternal Medicine, Division of Vascular Medicine and Pharmacology Molecular Medicine
Prof. dr. A.H. Jan Danser Assoc. Prof. dr. Xifeng Lu
Chapter 3
Publications (# = equal contribution, *= corresponding author)
Na Wang, Lishu He, Hui Lin, Lunbo Tan, Yuan Sun, Xiaoying Zhang, A.H. Jan Danser, Hong S. Lu, Yongcheng He, Xifeng Lu*. MicroRNA-148a regulates low-density lipoprotein metabolism by repressing the (pro)renin receptor, PLoS One 15: e0225356, 2020.
Yuan Sun, Alexandre Goes Martini, Manoe J. Janssen, Ingrid M. Garrelds, Rosalinde
Masereeuw, Xifeng Lu, A.H. Jan Danser*. Megalin: a novel endocytic receptor for prorenin and renin? Hypertension 75: 1242-1250, 2020.
Yuan Sun, Xifeng Lu, AH Jan Danser*. Megalin: a novel determinant of renin-angiotensin
system activity in the kidney? Curr Hyp Rep 22: 30, 2020.
Yuan Sun, Dominique M. Bovée, A.H. Jan Danser*. Tubular (pro) renin release: the curtain
falls. Hypertension 74: 26-28, 2019.
Estrellita Uijl#, Katrina M. Mirabito Colafella#, Yuan Sun, Liwei Ren, Richard van Veghel,
Ingrid M. Garrelds, René de Vries, Marko Poglitsch, Ivan Zlatev, Jae B. Kim, Ewout J. Hoorn, Don Foster, A.H. Jan Danser*. Strong and sustained antihypertensive effect of small interfering RNA targeting liver angiotensinogen. Hypertension 73:1249-1257, 2019
Liwei Ren#, Yuan Sun#, Hong Lu, Dien Ye, Lijuan Han, Na Wang, Alan Daugherty, Furong
Li, Miaomiao Wang, Fengting Su, Wenjun Tao, Jie Sun, Noam Zelcer, Adam E. Mullick, A.H. Jan Danser, Yizhou Jiang, Yongcheng He, Xiongzhong Ruan*, Xifeng Lu*. (Pro) renin receptor inhibition reprograms hepatic lipid metabolism and protects mice from diet- induced obesity and hepatosteatosis, Circ Res 122: 730-741, 2018.
Yuan Sun, A.H. Jan Danser, Xifeng Lu*. (Pro)renin receptor as a therapeutic target for the
treatment of cardiovascular diseases? Pharmacol Res 125: 48-56, 2017.
Awards
AHA New Investigator Travel Award 2019
AHA Paul Dudley White International Scholar 2019
Chinese government award for outstanding self-financed students abroad 2019