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Survivin and p53 expression was evaluated in human primary chondrosarcoma tumor tissue using previously constructed tissue microarrays containing 137 conventional chondrosarcomas

Title: A sight for sore eyes : assessing oncogenic functions of Hdmx and reactivation of p53 as a potential cancer treatment..

Title: A sight for sore eyes : assessing oncogenic functions of Hdmx and reactivation of p53 as a potential cancer treatment..

Under normal growth conditions, USP7, a de- ubiquitylase (DUB), removes ubiquitin from Hdm2 and Hdmx, which is essential for maintaining levels that are sufficient to inhibit

We have found that the treatment of several types of cells with Leptomycin B, which blocks nuclear export of proteins containing a Rev-like nuclear export signal, strongly

To examine this possibility, HEK293 cells were transfected with expression plasmids for Myc and His-tagged wt hdmx p53 BD or phosphorylation mutants either alone or in

Parental and RRHX transformed HER cells and the retinoblastoma cell lines Y79 and Weri1 were treated with 10 μM Nutlin-3 for 24 hours, and analyzed with immunoblotting using

Enhanced alternative splicing of Hdmx-pre-mRNA into the splice-variant Hdmx-S results in loss of function of Hdmx since it leads to reduced full-length Hdmx protein levels but not