Cover Page
The handle http://hdl.handle.net/1887/18929 holds various files of this Leiden University dissertation.
Author: Lange, Job de
Title: A sight for sore eyes : assessing oncogenic functions of Hdmx and reactivation of p53 as a potential cancer treatment
Date: 2012-05-09
A sight for sore eyes
Assessing oncogenic functions of Hdmx and reactivation of p53 as a potential
cancer treatment
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 9 mei 2012 klokke 13:45 uur
door
Job de Lange
geboren te Zwolle in 1982
Promotiecommissie:
Promotor: Prof. P. Ten Dijke Co‐promotor Dr. A.G. Jochemsen
Overige leden:
Prof. Dr. B.M. Burgering, UMC Utrecht Dr. P.A. Van der Velden
Dr. H. Van Attikum
Table of Contents
Chapter 1
General Introduction ... 5 Chapter 2
Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts ... 23
Chapter 3
High levels of Hdmx promote cell growth in a subset of uveal melanomas ... 51
Chapter 4
Synergistic growth inhibition based on small‐molecule p53
activation as treatment for intraocular melanoma ... 77
Chapter 5
Chk2 mediates RITA‐induced apoptosis ... 106
Chapter 6
General Discussion... 132
Nederlandse samenvatting... 142
Curriculum Vitae ... 147
List of publications ... 148
