University of Groningen
Decoding non-coding RNAs in fatty liver disease
Atanasovska, Biljana
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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Atanasovska, B. (2019). Decoding non-coding RNAs in fatty liver disease. University of Groningen.
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Propositions Belonging to the PhD Thesis
Decoding non-coding RNAs in fatty liver disease
1. Lipid metabolism is a key pathway that connects obesity, diabetes-related traits and cardiovascular disease as lipid-trait-associated genetic risk loci are shared with those predisposing to cardiometabolic phenotypes. (This thesis) 2. A liver-specific lncRNA, lnc18q22.2, is named as liver cell viability associated
lncRNA (LIVAR). It plays a critical role in hepatocyte viability and shows elevated expression in the liver of NASH patients. (This thesis)
3. Two liver-expressed lncRNAs, HNF4A-AS1 and RP11-91K9.1 (lncTNF), play a role in the inflammatory component of NASH development. (This thesis) 4. RNA expression profiling reveals lncRNAs involved in NAFLD, but experimental
follow-up studies are required to characterize their function. (This thesis) 5. Enhancer regions transcribed into enhancer RNA molecules provide new
insights into gene regulatory patterns in the liver. (This thesis)
6. Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty liver disease (NAFLD) and identification of factors that trigger the transition to NASH will help to design targeted therapies against the disease progression. (Schuster et al, Nature Reviews Gastroenterology & Hepatology, 2018).
7. More than 90% of the human genome is transcribed into RNA molecules, and the majority of these transcripts are not coding for proteins. (The ENCODE project, Nature, 2012)
8. The number of lncRNAs encoded by the genome has increased during animal evolution, suggesting that the presence of lncRNAs is linked to organismal complexity. (Necsulea et al, Nature, 2014)
9. The role of the infinitely small in nature is infinitely great. (Louis Pasteur) 10. Somewhere, something incredible is waiting to be known. (Carl Sagan)
Biljana Atanasovska 20th May 2019
