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University of Groningen The role of reconstructive surgery in the treatment of soft tissue sarcomas Slump, Jelena

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University of Groningen

The role of reconstructive surgery in the treatment of soft tissue sarcomas

Slump, Jelena

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Slump, J. (2018). The role of reconstructive surgery in the treatment of soft tissue sarcomas. University of Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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The role of reconstructive surgery in the

treatment of soft tissue sarcomas

f

g y

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Colofon

The research described in the thesis was financially supported by a grant from the Groningen Melanoma Sarcoma Foundation.

Financial support for printing this thesis was kindly provided by the Uni-versity Medical Center Groningen (UMCG), the Graduate School of Medical Schiences Groningen, ERBE Nederland B.V., Noord-Negentig Accountants en belastingadviseurs and Chipsoft B.V.

All clinical patient data were collected from the database of the University Musculoskeletal Oncology Unit at Mount Sinai Hospital in Toronto, Canada.

Cover design

Dineke Slump & Jelena Slump

Lay-out

Jelena Slump

Printed by

Ipskamp Printing, Enschede/Amsterdam

ISBN: 978-94-034-0860-6

ISBN (electronical): 978-94-034-0859-0

Copyright © 2018 J. Slump, Groningen, The Netherlands

All rights reserved. No part of this disseratation may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission from the author.

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The role of reconstructive surgery in the treatment

of soft tissue sarcomas

g y

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

maandag 24 september 2018 om 14.30 uur

door

Jelena Slump

geboren op 11 oktober 1988

te Heerenveen

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Promotores:

Prof. dr. H.J. Hoekstra

Prof. dr. S.O.P Hofer

Copromotor:

Dr. A.C. O'Neill

Beoordelingscommissie:

Prof. dr. J.H. Coert

Prof. dr. G.M. van Dam

Prof. dr. M. Verheij

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Paranimfen

Annelyt Slump

Yanieke Slump

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Table of Contents

1.

General introduction 9

2.

Risk factors for post-operative complications after soft tissue sarcoma limb resection of the extremities – A systematic review and meta-analyses

Submitted

23

3.

Can the ACS-NSQIP surgical risk calculator predict post-operative complications in patients undergoing flap reconstruction following soft tissue sarcoma resection?

Journal of Surgical Oncology. 2016 Oct;114(5):570-575

55

4.

Patient, tumour and treatment factors affect complication rates in soft tissue sarcoma flap reconstruction in a synergistic manner

European Journal of Surgical Oncology. 2017 Jun;43(6):1126-1133

71

5.

Flap reconstruction does not increase complication rates following surgical resection of extremity soft tissue sarcoma

European Journal of Surgical Oncology. 2018 Feb;44(2):251-259

89

6.

Flap choice does not affect complication rates or functional outcomes following extremity soft tissue sarcoma reconstruction

Journal of Plastic, Reconstructive & Aesthetic Surgery. 2018 Jul;71(7):989-996

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7.

Summary and conclusions 121

English summary

Nederlandse samenvatting - Dutch summary

8.

General discussion and future perspectives 133

9.

Appendices 143

Dankwoord - Acknowledgements

Author affiliations

Curriculum Vitae

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