University of Groningen
Localized extremity soft tissue sarcoma: towards a patient-tailored approach
Stevenson, Marc Gilliam
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Publication date: 2018
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Stevenson, M. G. (2018). Localized extremity soft tissue sarcoma: towards a patient-tailored approach. Rijksuniversiteit Groningen.
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FYN Werk, grafische vormgeving Fleur Bominaar www.fynwerk.nl Printed by Gildeprint, Enschede www.gildeprint.nl Sponsors
• The research described in this thesis was supported by a research grant from the Groningen Melanoma Sarcoma Foundation.
• The printing of this thesis was kindly supported by the University Medical Center Groningen (UMCG) and the Graduate School of Medical Sciences Groningen.
Localized extremity soft tissue sarcoma:
towards a patient-tailored approach
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 8 oktober 2018 om 14.30 uur
door
Marc Gilliam Stevenson
geboren op 25 januari 1991 te Roden
ISBN: 978-94-9301-432-9 (Book) ISBN: 978-94-9301-433-6 (E-Book) © 2018 Marc Stevenson, The Netherlands
All rights reserved. No part of this book may be reproduced, stored in a retreival system or trans-mitted in any form or by any means, without prior permisson of the author.
Promotores
Prof. dr. H.J. Hoekstra Prof. dr. A.J.H. Suurmeijer
Copromotor
Dr. L.B. Been
Beoordelingscommissie
Prof. dr. A.J. Gelderblom Prof. dr. J.H.B. Geertzen Prof. dr. H. Hollema
Paranimfen
Herman Helder Matthijs NijenhuisContents
1
General introduction & outline of this thesis 8 Part ITreatment of resectable extremity soft tissue sarcoma 18
2
Identification of predictors for wound complications following preoperative or postoperative radiotherapy in extremitysoft tissue sarcoma 20
Part II
Treatment of locally advanced extremity soft tissue sarcoma 42
3
Hyperthermic isolated limb perfusion, preoperativeradiotherapy, and surgery (PRS) a new limb saving treatment
strategy for locally advanced sarcomas 44
4
Amputations for extremity soft tissue sarcoma in an era of limbsalvage treatment: local control and survival 62
Part III
Metabolic and histopathological tumor responses in
pretreated extremity soft tissue sarcoma 84
5
Volume of interest delineation techniques for 18F-FDG PET-CTscans during neoadjuvant extremity soft tissue sarcoma treatment
in adults: a feasibility study 86
6
Histopathological tumor response following neoadjuvant hyperthermic isolated limb perfusion in extremity soft tissuesarcomas: evaluation of the EORTC-STBSG response score 112
7
Summary and conclusions 132Samenvatting en conclusies 138
