University of Groningen
Pathogenicity of alpha-synuclein in various cell models for Parkinson’s disease Quevedo Melo, Thaiany
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Publication date: 2018
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Quevedo Melo, T. (2018). Pathogenicity of alpha-synuclein in various cell models for Parkinson’s disease. University of Groningen.
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Pathogenicity of alpha-synuclein in various cell models
for Parkinson’s disease
Thaiany Quevedo Melo
_____________________________________________________________________________ The research described in this thesis was conducted at the Department of Genetics and Evolutionary Biology, Institute for Biosciences, University of São Paulo, São Paulo, Brazil and at the Department of Neuroscience, Section Medical Physiology, University Medical Center Groningen (UMCG), University of Groningen (RUG). This work was supported by CAPES, CNPQ, RUG and the graduate school of Behavioral and Cognitive Neuroscience (BCN). Printing of the thesis was financially supported by RUG, UMCG & BCN.
ISBN/ EAN: 978-94-034-0556-8/ 978-94-034-0557-5 NUR- code: 882
Cover: T. Quevedo Melo
Lay-out and printing: Ipskamp Printing
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Pathogenicity of alpha-synuclein in various cell models
for Parkinson’s disease
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Wednesday 18th of April at 16:15 hours
by
Supervisor
Prof. H.W.G.M. Boddeke
Co-supervisor Dr. J.C.V.M. Copray
Assessment committee Prof. T. van Laar
Prof. U.L.M. Eisel Prof. M. Schmidt
TABLE OF CONTENTS
Chapter 1- General Introduction ...7
Chapter 2 – Alpha-synuclein effects upon intracellular trafficking and cellular stress in Parkinson’s disease ...23
Chapter 3- Expression of anterograde and retrograde motor proteins and mitochondrial mobility in brain areas exposed to rotenone ...55
Chapter 4- Impairment of mitochondria dynamics by human A53T a-synuclein and rescue by NAP (Davunetide) in a cell model for Parkinson’s disease ...77
Chapter 5- Mitochondria trafficking impairment in dopaminergic neurons from Parkinson patient-derived iPS cells ...105
Chapter 6- Absence of GEM (Miro) reduces alpha-synuclein toxicity in a yeast model to study Parkinson’s disease ...131
Chapter 7- Summary and Conclusions ...165
Chapter 8- Dutch Summary ...177
ACKNOWLEDGEMENTS ...183
