University of Groningen
Harnessing the reactivity of alkenyl heteroarenes through copper catalysis and Lewis acids
Lanza, Francesco
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Publication date: 2018
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Lanza, F. (2018). Harnessing the reactivity of alkenyl heteroarenes through copper catalysis and Lewis acids. University of Groningen.
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Behorende bij het proefschrift
Harnessing the Reactivity of Alkenyl Heteroarenes Through Copper Catalysis and Lewis Acids
Van Francesco Lanza
1. When the performance of a search engine built specifically for bibliographic research is exceeded by Google, then it’s time for an upgrade.
2. The success of a PhD study should not be judged from the IF/number of publications, but rather the quality with which the research has been conducted.
3. Characterization and identification of side products should not be undervalued or overlooked. It can lead to the discovery of new processes/reactivity. (Chapter 3, this thesis)
4. The contract of a PhD with insufficient material, both in terms of quality and quantity, to write his/her own thesis should be terminated before it reaches its end. Lack of sufficient results does not occur suddenly at the last moment.
5. When Lewis acids are considered, stronger Lewis acidity does not always translate into higher activation. Stabilization of reaction intermediates has to be taken into account. (Chapter 5, this thesis)
6. The development of a new catalytic process should always starts with the study of the blank reaction (reaction in absence of the catalyst), even when it might seem to be unnecessary.
7. Although correct, complaints aimed at the storage of a few chemicals in or under a fume hood become questionable, when working in laboratories in which hundreds of chemicals are stored in simple, wooden cabinets that often lack proper ventilation.
8. Assessing the reproducibility of a reaction by the same operator is considered good practice, yet the data obtained from such efforts is hardly reliable! Instead, different operators should perform the same reaction, thereby providing a more relevant data set concerning the true reproducibility of a chemical reaction (R. G. Bergman, R. L. Danheiser, Angew. Chem. Int. Ed., 2016, 55, 12548 – 12549).
9. Rather than a prerequisite to define a reaction as “catalytic”, the fact that a catalyst can be employed in small quantities is a desirable and logical consequence of it not being consumed during the reaction. Therefore, the widespread expression “catalytic amount” is conceptually inaccurate and the use of terms, such as “substoichiometric”, would be more appropriate.
