University of Groningen
Multifaceted effects of anti-inflammatory pectins in protecting β-cells and reducing responses against immunoisolating capsules for cell transplantation
Hu, Shuxian
DOI:
10.33612/diss.149819517
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hu, S. (2021). Multifaceted effects of anti-inflammatory pectins in protecting β-cells and reducing responses against immunoisolating capsules for cell transplantation. University of Groningen.
https://doi.org/10.33612/diss.149819517
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Multifaceted effects of anti-inflammatory pectins in protecting β-cells and
reducing responses against immunoisolating capsules for cell transplantation
1. The rational selection of biocompatible encapsulation materials can minimize undesired tissue responses while maintaining the device’s functionality. (chapter 1)
2. The dietary fiber pectin prevents diabetes by not only altering glucose tolerance, but also by making insulin producing β-cells less susceptible for stress. (chapter 2)
3. Pectin-induced inhibition of Galectin-3 rescues insulin-producing β cells from oxidative and inflammatory stress. (chapter 2)
4. Specific short chain fatty acids at a correct concentration can beneficially influence ‘gut– pancreatic islet’ interactions. (chapter 3)
5. A better understanding of structure-function relations of pectins and how cell membrane receptors interact with functional domains of pectin contribute to rational choices for using pectin for specific health benefits. (chapter 4)
6. The application of the immunomodulatory polymer pectin could be a relative simple and low-cost way to manage undesired inflammatory responses. (chapter 4)
7. A highly biocompatibility, low volume, and oxygen diffusion-friendly immunoisolating islet transplantation device can be obtained through combining immunoregulatory bioinks and 3D-bioprinting. (chapter 5)
8. Tell me what you eat, and I will tell you what you are. (Jean Anthelme Brillat-Savarin) 9. Cherish today, and treasure the present moment. Who knows what will come first -
tomorrow or another round of lockdown.
PROPOSITIONS
BELONGING TO THIS DISSERTATION
Shuxian Hu
