University of Groningen
Elucidating the mechanisms of anastomotic leakage
van Praagh, Jasper
DOI:
10.33612/diss.119066366
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Praagh, J. (2020). Elucidating the mechanisms of anastomotic leakage: a new point of view. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.119066366
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Elucidating the Mechanisms
of Anastomotic Leakage
A New Point of View
van Praagh, Jasper B.
Elucidating the Mechanisms of Anastomotic Leakage, A New Point of View
PhD dissertation, University of Groningen, The Netherlands
ISBN: 978-94-6375-726-3
ISBN (electronic version): 978-94-034-2440-8
© Copyright 2020 – Jasper B. van Praagh, Groningen, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior permission of the author or, when appropriate, of the publisher of the published articles.
Cover design & Lay-out: Lara Leijtens, persoonlijkproefschrift.nl Print: Ridderprint | www.ridderprint.nl
Elucidating the Mechanisms of
Anastomotic Leakage
A New Point of View
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 11 november 2020 om 16.15 uur
door
Jasper Boudewijn van Praagh
geboren op 6 maart 1991 te Amsterdam
Promotores
Prof. dr. P. Olinga Prof. dr. H. van Goor
Copromotores Dr. K. Havenga Dr. H.J.M. Harmsen Beoordelingscommissie Prof. dr. R.K. Weersma Prof. dr. H.G.D. Leuvenink Prof. dr. P.J. Tanis Paranimfen Boris A. de Cort Joost C. Beusekamp
OUTLINE
Chapter 1 General Introduction and Outline of this Thesis 6 Chapter 2 Intestinal Microbiota and Anastomotic Leakage of Stapled
Colorectal Anastomoses: A Pilot Study
Surgical Endoscopy 2016
18
Chapter 3A Mucus Microbiome of Anastomotic Tissue During Surgery Has
Predictive Value for Colorectal Anastomotic Leakage
Annals of Surgery 2018
32
Chapter 3B Response to Comment on “Mucus Microbiome of Anastomotic
Tissue During Surgery Has Predictive Value for Colorectal Anastomotic Leakage”
Annals of Surgery 2019
48
Chapter 4 Microbiome Research: A Primer for the Interested Surgeon
Submitted 54
Chapter 5 Transcriptomic Profiles of Samples From Colorectal Anastomosis of Patients Developing Anastomotic Leakage Show a Distinct Signature
Submitted
78
Chapter 6 Workflow and Methods to Determine the Role of Bacteria in Anastomotic Leak Pathogenesis From Human Samples: Defining the Role of Bacillus subtilis
Submitted
104
Chapter 7 Western Diet Promotes Intestinal Colonization with Collagenolytic Microbiota and Drives Tumour Formation Following Colorectal Surgery
Gastroenterology 2019
116
Chapter 8 Summary, General Discussion and Conclusion 146 Chapter 9 Dutch Summary
Nederlandse Samenvatting 162 Appendices Dankwoord Publicaties Over de auteur 170 176 178
THE DARK SIDE OF THE MOON
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