Insights in tumorigenesis and metastasis of uveal melanoma
Notting, I.C.
Citation
Notting, I. C. (2009, January 27). Insights in tumorigenesis and metastasis of uveal melanoma. Retrieved from https://hdl.handle.net/1887/13532
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/13532
Note: To cite this publication please use the final published version (if applicable).
Insights in Tumorigenesis Metastasis and
Uveal Melanoma of
The studies described in this thesis were performed at the departments of Ophthalmo- logy and Endocrinology of the Leiden University Medical Center, The Netherlands.
Cover: Fleur Notting, New York, USA.
Printed by Ponsen en Looijen, Wageningen, The Netherlands ISBN: 978-90-6464-320-0
Copyright I.C. Notting, Leiden, The Netherlands. All rights reserved. No part of this thesis may be reproduced or copied, in any form or by any means, without prior permission of the author.
Financial support for the publication of this thesis was provided by Alcon Nederland, Allergan, Bausch en Lomb, Carl Zeiss, Dutch Cancer Society, Lameris Ootech, Landelijke Stichting voor Blinden en Slechtzienden, Leids Oogheelkundig Ondersteunings Fonds, MSD, Novartis, Pfizer, Stichting Blinden-Penning, Tramedico Nederland.
Insights in Tumorigenesis and Metastasis
of Uveal Melanoma
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 27 januari 2009 klokke 16.15 uur door
Irene Christa Notting geboren te Nijmegen
in 1976
Promotiecommissie
Promotors: Prof. Dr. N.E. Schalij-Delfos Prof. Dr. J.E.E. Keunen
(Radboud Universiteit Nijmegen) Copromotor: Dr. G. Van der Pluijm
Referent: Prof. Dr. P. ten Dijke
Overige Leden: Prof. Dr. M. Bracke (Universiteit Gent) Prof. Dr. C. Löwik
Prof. Dr. J. Nortier
voor mijn ouders
Chapter 1 Introduction to Insights of Tumorigenesis and Metastasis
of Uveal Melanoma 9 - 32
Chapter 2 Whole Body Bioluminescent Imaging of Human Uveal Melanoma in a New Mouse Model for Local Tumor Growth
and Metastasis 33 - 46
Chapter 3 Bone Morphogenetic Protein 7 Inhibits Tumor Growth
of Human Uveal Melanoma in vivo 47 - 64
Chapter 4 BMP antagonist DAN in Uveal Melanoma progression 65 - 78 Chapter 5 Angiogenic Profile in Uveal Melanoma 79 - 96 Chapter 6 Vascular Endothelial Growth Factor-A in Eyes with
Uveal Melanoma 97 - 112
Chapter 7 General Discussion 113 - 120
Chapter 8 Samenvatting en conclusies 121-124
Curriculum vitae 125
List of publications 127
Contents
