Cancer and inflammation studies using zebrafish cell lines
He, S.
Citation
He, S. (2010, May 27). Cancer and inflammation studies using zebrafish cell lines. Retrieved from https://hdl.handle.net/1887/15555
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Cancer and inflammation studies using zebrafish cell lines
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 27 mei 2010 klokke 13:45 uur
door
Shuning He
geboren te Nanjing, Jiangsu, China in 1980
Promotion Committee
Promoter: Prof. Dr. H.P. Spaink Co-promoter: Dr. B.E. Snaar-Jagalska Other Members: Prof. Dr. P.J.J. Hooykaas Prof. Dr. A.J. Durston Prof. Dr. B. van der Water Prof. Dr. J. den Hertog
Dr. M. Mione (IFOM, Milan, Italy)
ISBN: 978-90-8570-565-9
Printed by Wöhrmann Print Service, Zutphen
“It never will rain roses. When we want to have more roses we must plant trees.”
George Eliot
“One has to be an optimist in science because most of the time it doesn't work.”
Oliver Smithies
For my grandparents and parents
⤂㒭៥ⱘ⠋⠋ཊཊ⠌⠌ཛྷཛྷ
Contents
Chapter 1 General introduction: zebrafish cells as models for biomedical research
7
Chapter 2 Genetic and transcriptome characterization of model zebrafish cell lines
23
Chapter 3 Toll-like receptor signaling in zebrafish cell lines 41 Chapter 4 An inducible oncogenic zebrafish liver cell
model to study hepatocellular carcinoma
63
Chapter 5 Profile of phosphorylation events controlled by hyper-activation of the MAPK signaling pathway in zebrafish liver cells
83
Chapter 6 General discussion 99
Samenvatting 109
Curriculim Vitae 111
Publications 113
Acknowledgements (in English and Chinese) 115
