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The handle http://hdl.handle.net/1887/62866 holds various files of this Leiden University dissertation
Author: Nooij, Linda
Title: Vulvar cancer : pathogenesis, molecular genetics and treatment
Date: 2018-06-28
Vulvar cancer;
pathogenesis, molecular genetics and treatment
Linda Suzanne Nooij
Vulvar cancer; pathogenesis, molecular genetics and treatment
The research described in this thesis was performed at the department of Gynaecology and Pathology at the Leiden University Medical Center, Leiden, the Netherlands.
All rights reserved. No parts of this thesis may be reproduced, distributed, stored in a retrieval system or transmitted in any forms or by any means without prior written permission of the author.
Financial support for printing of this thesis was kindly provided by Leiden University, the departments of gynaecology and pathology of the Leiden University Medical Center, Raad van Bestuur Haaglanden Medisch Centrum, Nederlandse Vereniging voor Vulvapathologie, Stichting Olijf, Pfizer, Chipsoft.
Vulvar cancer;
pathogenesis, molecular genetics and treatment
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. C.J.J.M. Stolker
volgens besluit van het College voor Promoties te verdedigen op donderdag 28 juni 2018
klokke 16.15 uur door
Linda Suzanne Nooij Geboren te Amsterdam in 1980
Prof. Dr. M.J. vd Vijver (VUMC / AMC, Amsterdam) Dr. J.A. de Hullu (Radboudumc, Nijmegen)
Table of contents
Chapter 1 General introduction and outline of the thesis
Chapter 2 Tumour-free margins in vulvar squamous cell carcinoma:
Does distance really matter?
Chapter 3 Groin surgery and risk of recurrence in lymph node positive patients with vulvar squamous cell carcinoma Chapter 4 Risk factors and treatment for recurrent vulvar squamous
cell carcinoma
Chapter 5 Genetic and epigenetic changes in vulvar squamous cell carcinoma and its precursor lesions: a review of the current literature
Chapter 6 Stathmin is a highly sensitive and specific biomarker for vulvar high-grade squamous intraepithelial lesions Chapter 7 Genomic characterization of vulvar (pre)cancers identifies
distinct molecular subtypes with prognostic significance Chapter 8 General discussion and summary
Appendices Nederlandse samenvatting List of abbreviations List of publications
Dankwoord
Curriculum Vitae
7 25 49 69 101
139 155
181 202 208 210 212 215
