Cover Page
The handle http://hdl.handle.net/1887/78948 holds various files of this Leiden University
dissertation.
Author: Giacomelli, E.
BUILDING BLOCKS OF THE HUMAN HEART
Colophon
Building blocks of the human heart
PhD thesis
This thesis was prepared at the Department of Anatomy & Embryology of the Leiden University Medical Center, Leiden, The Netherlands.
Copyright © Elisa Giacomelli, Leiden, the Netherlands, 2019.
All rights reserved. No parts of this book may be reproduced or transmitted, in any forms and by any means, without permission in writing from the author. The copyright of the articles that have been published has been transferred to the respective journals.
The research described in this thesis as well as its publications was supported by the following grants: European Research Council (ERCAdG 323182 STEMCARDIOVASC) and Transnational Research Project on Cardiovascular Diseases (JTC2016_FP-40-021 ACM-HF).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
ISBN: 978-94-6380-428-8
Building blocks of the human heart
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 1 oktober 2019 klokke 12.30 uur
door
Elisa Giacomelli
Promotor Prof.dr. C.L. Mummery Co-Promotoren Dr. M. Bellin Dr. V.V. Orlova Promotiecommissie Prof.dr. M.J.T.H Goumans Prof.dr. D.E Atsma Prof.dr. P.C.J.J. Passier
Chapter 1
Introduction of the thesis Chapter 2
Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes
Chapter 3
Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells Chapter 4
Co-differentiation of human pluripotent stem cells-derived cardiomyocytes and endothelial cells from cardiac mesoderm provides a three-dimensional model of cardiac microtissue
Chapter 5
Human pluripotent stem cell differentiation into functional epicardial progenitor cells
Chapter 6
