A MRI study into the effect of pravastatin on cerebrovascular pathologies

A MRI study into the effect of pravastatin on cerebrovascular

pathologies

Dam, V.H. ten

Citation

Dam, V. H. ten. (2007, June 21). A MRI study into the effect of pravastatin on

cerebrovascular pathologies. Retrieved from https://hdl.handle.net/1887/12091

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the

Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/12091

Note: To cite this publication please use the final published version (if applicable).

A MRI Study into the Effect of Pravastatin

on Cerebrovascular Pathologies

V.H. ten Dam

ISBN: 978-90-9021908-0

Designed by: APR van Seters Printed by: Gilde Print, Utrecht

No part of this thesis may be reproduced in any form by print, photocopy, digital file, internet or any other means without written permission of the copyright owner.

The studies described in this thesis were performed at the department of Radiology and Gerontology and Geriatrics of the Leiden University Medical Center, Leiden, The Netherlands and were financially supported by an investigator initiated grant from Bristol-Myers Squibb, Princeton USA. The sponsor had no role in the design, data collection, data analysis, data interpretation of the study or writing of the paper.

A MRI Study into the Effect of Pravastatin

on Cerebrovascular Pathologies

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties, te verdedigen op donderdag 21 juni 2007

klokke 15.00 uur door

Valerie Hester ten Dam geboren te Epe

in 1971

Promotores:

Prof. Dr. R.G.J. Westendorp Prof. Dr. M.A. van Buchem

Co-Promotor:

Dr. G.J. Blauw

Referent:

Prof. Dr. J. Shepherd

Overige leden:

Prof. Dr. A. Algra Prof. Dr. R.A.C. Roos

Contents

1. General Introduction 7

2. The PROspective Study of Pravastatin in the Elderly at Risk 15

3. Measuring longitudinal white matter changes: comparison of a visual

rating scale with a volumetric measurement 23

4. Impact of cardiovascular risk factors on the progression of

periventricular and deep white matter hyperintensities 41

5. Decline in total cerebral blood flow is linked with increase in

periventricular but not deep white matter hyperintensities 59

6. Periventricular white matter hyperintensities predict occurrence of

subcortical cerebral infarcts 77

7. Lack of effect of pravastatin on cerebral blood flow or parenchymal

volume loss in elderly at risk for vascular disease 91

8. Effect of pravastatin on cerebral infarcts and white matter lesions 105

9. General Discussion 117

Samenvatting 131

List of publications 135

Nawoord 137

Curriculum Vitae 139