University of Groningen
Isoflurane induced eNOS signaling and cardioprotection Baotic, Ines
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Baotic, I. (2018). Isoflurane induced eNOS signaling and cardioprotection: Preconditioning mechanisms under normal and hyperglycemic conditions. University of Groningen.
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Propositions:
1. Endothelial nitric oxide (eNOS) related signaling events in anesthetic preconditioning are adversely modulated by hyperglycemia and diabetes. (this thesis)
2. Isoflurane preconditioning of the heart favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats. (this thesis)
3. Anesthetic preconditioning enhances the endothelial production of nitric oxide, thus protecting cardiomyocytes against hypoxia and reoxygenation injury in a co-culture cell model. (this thesis)
4. The efficacy of anesthetic preconditioning in mitigation of cardiac
ischemia/reperfusion injury is dependent on the mitochondrial DNA genome. (this
thesis)
5. Loss of cardioprotective (AP)-conditioning signaling in hyperglycemia and diabetes is critically dependent on alterations of mitochondrial bioenergetics. (this thesis) 6. The Apolipoprotein A-1 mimetic, D-4F, enhances isoflurane-induced nitric oxide
signaling and redresses the loss of cardioprotection during acute hyperglycemia. (this thesis)
7. The amount of sodium that is used as an excipient should be clearly stated on the label and package leaflet of all medicinal products for human use.
8. As childhood obesity is rapidly increasing in prevalence, programs to advise parents on its primary and secondary prevention need to be deployed or endorsed.
