University of Groningen
Isoflurane induced eNOS signaling and cardioprotection
Baotic, Ines
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Baotic, I. (2018). Isoflurane induced eNOS signaling and cardioprotection: Preconditioning mechanisms under normal and hyperglycemic conditions. University of Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Isoflurane Induced eNOS Signaling
and Cardioprotection
Preconditioning Mechanisms under
Normal and Hyperglycemic Conditions
Studies presented in this thesis were financially supported by
University Medical Centre Groningen (UMCG), Groningen, Netherlands Medical College of Wisconsin (MCW), Milwaukee, Wisconsin, USA “Vuk Vrhovac” University Clinic for diabetes, endocrinology and metabolic diseases, Zagreb, Croatia
ISBN (printed version): 978-94-034-1205-4 ISBN (digital version): 978-94-034-1204-7
Front cover design & lay-out: Petra Bilić Križan (dizajncafe.petra@gmail.com) Printing: Gildeprint, Enschede, NL
Copyright 2018 Ines Baotic
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form by any means, without permission of the author.
Isoflurane Induced eNOS Signaling
and Cardioprotection
Preconditioning Mechanisms under Normal and Hyperglycemic Conditions
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 12 December 2018 at 11.00 hours
by
Ines Baotic
born on 9 December 1970Supervisor Prof. R.H. Henning Co-supervisor Dr. A.H. Epema Assessment Committee Prof. B.J.J.M. Brundel Prof. S.J.L. Bakker Prof. T.W.L. Scheeren
This PhD thesis is dedicated to
My family, husband Tomislav, son Juraj Kresimir and
daughter Luciana, for their unconditional love and support
VII
Chapter 1
General Introduction and Scope of the Thesis . . . . 1
Chapter 2
Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase during Myocardial Ischemia and Reperfusion Injury in Rats . . . . 27
Chapter 3
Endothelial–cardiomyocyte crosstalk enhances
pharmacological cardioprotection . . . . 47
Chapter 4
Cardioprotection during Diabetes
The Role of Mitochondrial DNA . . . . 77
Chapter 5
Mitochondrial Bioenergetics in Diabetic Myocardium –
Implications for Protective Conditioning Strategies . . . . 99
Chapter 6
Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling
and cardioprotection during acute hyperglycemia . . . . 149
Chapter 7
General Discussion and Future Perspectives . . . . 173
Addendum
Nederlandse Samenvatting, Acknowledgements - Dankwoord, Bibliography, References (all chapters) . . . . 191
