University of Groningen
Biological Pathways in the Development of Dupuytren’s and Peyronie’s Diseases
ten Dam, Evert-Jan
DOI:
10.33612/diss.146362351
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
ten Dam, E-J. (2020). Biological Pathways in the Development of Dupuytren’s and Peyronie’s Diseases. University of Groningen. https://doi.org/10.33612/diss.146362351
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Biological Pathways in the Development
of Dupuytren’s and Peyronie’s Diseases
2 Colofon
This PhD project was financially supported by the University Medical Center Groningen.
Financial support for printing this thesis was obtained by contributions from the Department of Plastic Surgery and Graduate School of Medical Sciences of the UMCG, NVPC, JVPC, ChipSoft, Van Wijngaarden Medical, KM Innovations and BAP Medical.
Cover: proefschriftontwerp.nl Layout: Evert-Jan ten Dam Printed by: Ipskamp printing
© Copyright 2020 Evert-Jan P.M. ten Dam
All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without written permission of the author or the publisher holding the copyright of the published articles.
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Biological Pathways in the
Development of Dupuytren’s and
Peyronie’s Diseases
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op dinsdag 8 december om 12.45 uur
door
Evert-Jan Paulus Maria ten Dam
geboren op 28 februari 1986 te Oldenzaal
4
Promotores
Prof. dr. P.M.N. Werker
Prof. dr. R.A. Bank
Beoordelingscommissie
Prof. dr. B. Van der Lei
Prof. dr. P. Olinga
Prof. dr. D. Furniss
Paranimfen
Dr. J.C.N. Willemsen
Drs. F.F. Odding
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TABLE OF CONTENTS
Chapter 1 Introduction and outline
Chapter 2 Further evidence of the involvement of the Wnt signaling pathway in Dupuytren’s disease
Journal of Cell Communication and Signaling, 2016
Chapter 3 Wnt pathway in Dupuytren’s disease, connecting
pro-fibrotic signals
Translational Research, 2015
Chapter 4 Matrix and cell phenotype differences in Dupuytren's disease
Fibrogenesis Tissue Repair, 2016
Chapter 5 Inhibiting Wnt signaling in Dupuytren’s disease myofibroblasts may attenuate fibrosis: a pilot study Submitted
Chapter 6 Glimpses into the molecular pathogenesis of Peyronie’s disease
The Aging Male, 2019
Chapter 7 General discussion and future perspectives
Chapter 8 Summary
Samenvatting Dankwoord About the author
7 19 39 65 89 111 131 153
