Genes, inflammation, and age-related diseases
Trompet, S.
Citation
Trompet, S. (2010, June 2). Genes, inflammation, and age-related diseases. Retrieved from https://hdl.handle.net/1887/15579
Version: Corrected Publisher’s Version
Genes, inflammation, and age-related diseases
Stella Trompet
Printed by Stimuka B.V, Rijswijk
ISBN ?
Cover design and layout by Niels Mansveld Visual Media
Genes, inflammation, and age-related diseases
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 2 juni 2010
klokke 15.00
door Stella Trompet
geboren te ‘s-Gravenhage in 1981
Promotie commissie
Promotoren: Prof. Dr. J. W. Jukema Prof. Dr. R. G. J. Westendorp
Co-promotor: Dr. A. J. M. de Craen
Overige Leden: Prof. Dr. J. Gussekloo
Prof. Dr. J. Shepherd (University of Glasgow, United Kingdom) Prof. Dr. P. E. Slagboom
Prof. Dr. A. G. Uitterlinden (Erasmus MC, Rotterdam, The Netherlands)
Contents
Chapter 1. General introduction 7
Chapter 2. Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke.
The PROSPER study 23
Chapter 3. Genetic variation in the interleukin-10 gene promoter and risk of
coronary and cerebrovascular events: the PROSPER study 37
Chapter 4. Genetic variation in the interleukin-1 beta-converting enzyme
associates with cognitive function. The PROSPER study 49
Chapter 5. Variation in the IL-10 gene is a marker for risk prediction of
cognitive function 69
Chapter 6. High innate production capacity of pro-inflammatory cytokines
increases risk of death from cancer. Results of the PROSPER study 87
Chapter 7. Variation in the CBP gene involved in epigenetic control associates
with cognitive function 101
Chapter 8. The -2481C variant allele of the lysine acetyltransferase PCAF is associated with reduced vascular mortality. Results from three
independent prospective studies 117
Chapter 9. ApoE genotype, plasma cholesterol, and cancer: a Mendelian
randomization study 145
Chapter 10. General discussion 161
Nederlandse samenvatting 171
List of publications 176
Dankwoord 178
Curriculum Vitae 179
