University of Groningen
Effectiveness and safety of medicines used in COPD patients Wang, Yuanyuan
DOI:
10.33612/diss.123921981
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Publication date: 2020
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Wang, Y. (2020). Effectiveness and safety of medicines used in COPD patients: pharmacoepidemiological studies. University of Groningen. https://doi.org/10.33612/diss.123921981
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Effectiveness and safety of
medicines used in COPD patients
Pharmacoepidemiological studies
Effectiveness and safety of medicines used in COPD patients
Pharmacoepidemiological studies
ISBN: 978-94-034-2555-9 (printed version) ISBN: 978-94-034-2554-2 (electric version)
Author: Yuanyuan Wang
Cover-design: IRINA SHI (photo) & Off Page (content)
Printing: Off Page (www.offpage.nl)
The studies presented in this thesis were funded by University of Groningen and the China Scholarship Council (CSC) Scholarship. This thesis was conducted within the Groningen University Institute for Drug Exploration (GUIDE). Printing of this thesis was financially supported by the University of Groningen and the Graduate School of Science and Engineering (GSSE).
Copyright ©Yuanyuan Wang, 2020, Groningen, The Netherlands.
All rights reserved. No part of this book may be reproduced or transmitted in any form by any means, electronically or mechanically by photocopying, recording, or otherwise, without the written permission of the author. The copy right of previously published chapters of this thesis remains with the publisher or journal.
Paranymphs: Jurjen van der Schans Yanni Li
Effectiveness and safety of
medicines used in COPD patients
Pharmacoepidemiological studies
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Friday 8 May 2020 at 14.30 hours
by
Yuanyuan Wang
born on 15 February 1988 in Henan, China
Supervisors
Prof. . Ha Prof. H.M. oe enAssessment Committee
Prof. T. .M. erheijProf. . van der Palen Prof. . tienstra
TABLE OF CONTENTS
Chapter 1 General Introduction 7
Part I Effects of antibiotic use for COPD exacerbations and potential DDIs during COPD exacerbation management
Chapter 2 Effects of Prophylactic Antibiotics on Patients with Stable COPD: 21 A Systematic Review and Meta-Analysis of
Randomized Controlled Trials
Chapter 3 The influence of age on real-life effects of doxycycline for 43 acute exacerbations among COPD outpatients:
a population-based cohort study
Chapter 4 Real-world short- and long-term effects of antibiotic therapy on 61 acute exacerbations of COPD in outpatients:
a cohort study under the PharmLines Initiative
Chapter 5 Improving antibacterial prescribing safety in 81 the management of COPD exacerbations:
systematic review of observational and clinical studies on
potential drug interactions associated with frequently prescribed antibacterials among COPD Patients
Part II Neuropsychiatric safety of varenicline use for smoking cessation and the application of prescription sequence symmetry analysis in drug safety evaluation
Chapter 6 Neuropsychiatric safety of varenicline in the general and 119 COPD population with and without psychiatric disorders:
a retrospective inception cohort study in a real-world setting
Chapter 7 Risk of neuropsychiatric adverse events associated with 145 varenicline treatment for smoking cessation:
a prescription sequence symmetry analysis
Chapter 8 Effect estimate comparison between the prescription 165 sequence symmetry analysis and parallel group study designs:
a systematic review
Chapter 9 General discussion 183
Chapter 10 Summary 197
Samenvatting 201
Acknowledgement 204
List of publications 208
About the author 211
Supervisors
Prof. . Ha Prof. H.M. oe enAssessment Committee
Prof. T. .M. erheijProf. . van der Palen Prof. . tienstra
