University of Groningen
DNA-based drug carriers and dynamic proteoids with tunable properties Liu, Yun
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Publication date: 2017
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Liu, Y. (2017). DNA-based drug carriers and dynamic proteoids with tunable properties. University of Groningen.
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DNA-based drug carriers and dynamic
proteoids with tunable properties
The work described in this thesis was carried out at the Stratingh Institute for Chemistry, University of Groningen, The Netherlands.
This work was financially supported by the Chinese Scholarship Council.
DNA-based drug carriers and
dynamic proteoids with tunable
properties
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Friday 10 March 2017 at 12.45 hours
by
Yun Liu
born on 16 June 1987 in Henan, China
Supervisors Prof. A. K. H. Hirsch Prof. A. J. Minnaard Assessment committee Prof. K. U. Loos Prof. S. Otto Prof. N. Katsonis
ISBN: 978-90-367-9509-8 (printed version)
To
Table of Contents
Chapter 1 Nucleic Acid Amphiphiles as Drug Carriers ... 1
1.1 Introduction ... 2
1.2 Self-assembled DNA nanocarriers ... 4
1.3 Amphiphilic DNA nanocarriers ... 5
1.4 Conclusions and outlook ... 11
1.5 Outline for this thesis ... 13
1.6 References ... 13
Chapter 2 Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers ... 19
2.1 From constitutional dynamic chemistry to dynamers ... 20
2.2 Molecular biodynamers: molecular/covalent dynamers with biologically relevant monomers ... 21
2.3 Molecular biodynamers: DyNAs, glycodynamers and dynamic proteoids .... 23
2.4 Conclusions and outlook ... 35
2.5 References ... 36
Chapter 3 Lipid-Modified DNAs as Solubilizers of Foscan ... 39
3.1 Introduction ... 40
3.2 Results and discussion ... 42
3.3 Conclusions ... 52
3.4 Experimental section ... 53
3.5 Contributions from co-authors ... 57
3.6 References ... 57
Chapter 4 Lipid-Modified-DNA Based Delivery System for Budesonide ... 59
4.1 Introduction ... 60
4.2 Results and disscussion ... 61
4.3 Conclusions ... 65
4.4 Experimental section ... 66
4.5 Contributions from co-authors ... 68
Chapter 5 Proteoid Dynamers with Tunable Properties ... 71
5.1 Introduction ... 72
5.2 Results and discussion ... 73
5.3 Conclusions ... 84
5.4 Experimental section ... 85
5.5 Contributions from co-authors ... 100
5.6 References ... 100
Chapter 6 Dynamic Proteoids: Biodynamers Generated from Amino Acid- or Dipeptide-Based Monomers ... 103
6.1 Introduction ... 104
6.2 Results and discussion ... 104
6.3 Conclusions ... 116
6.4 Experimental section ... 116
6.5 Contributions from co-authors ... 125
6.6 References ... 125
Summary ... 127
Samenvatting ... 131
